Targeting synaptic plasticity in schizophrenia: insights from genomic studies

Patients with schizophrenia experience cognitive dysfunction and negative symptoms that do not respond to current drug treatments. Historical evidence is consistent with the hypothesis that these deficits are due, at least in part, to altered cortical synaptic plasticity (the ability of synapses to...

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Veröffentlicht in:	Trends in molecular medicine 2021-11, Vol.27 (11), p.1022-1032
Hauptverfasser:	Mould, Arne W., Hall, Nicola A., Milosevic, Ira, Tunbridge, Elizabeth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Genomics Humans Neuronal Plasticity - genetics plasticity schizophrenia Schizophrenia - drug therapy Schizophrenia - genetics Synapses - metabolism Synaptic Transmission target identification translation
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