Prognostic Value of Tumor‐Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma
Objectives/Hypothesis Tumor‐infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value of TILs in sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether TILs can be used as a prognostic indicator for survival in SNMM. Stud...
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| Veröffentlicht in: | The Laryngoscope 2022-07, Vol.132 (7), p.1334-1339 |
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| container_title | The Laryngoscope |
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| creator | Ledderose, Stephan Ledderose, Carola Penkava, Josef Ledderose, Georg J. |
| description | Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value of TILs in sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether TILs can be used as a prognostic indicator for survival in SNMM.
Study Design
Retrospective cohort study.
Methods
Patient history and histologic specimens from 27 patients with primary SNMM were retrospectively analyzed. TIL grade was determined and associations between TILs and AJCC tumor stage, overall survival, and recurrence‐free survival were analyzed.
Results
Patients with TILs in the primary tumor classified as brisk or non‐brisk survived significantly longer than patients with SNMMs lacking lymphocyte infiltrates. Brisk TILs were associated with the lower T3 stage and increased recurrence‐free and 5‐year survival.
Conclusion
Our results indicate that TIL density is a strong prognostic factor for better survival in SNMM. Prospective studies with larger case numbers are warranted to determine whether TILs should be included in future AJCC staging guidelines.
Level of Evidence
3 Laryngoscope, 132:1334–1339, 2022 |
| doi_str_mv | 10.1002/lary.29820 |
| format | Article |
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Tumor‐infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value of TILs in sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether TILs can be used as a prognostic indicator for survival in SNMM.
Study Design
Retrospective cohort study.
Methods
Patient history and histologic specimens from 27 patients with primary SNMM were retrospectively analyzed. TIL grade was determined and associations between TILs and AJCC tumor stage, overall survival, and recurrence‐free survival were analyzed.
Results
Patients with TILs in the primary tumor classified as brisk or non‐brisk survived significantly longer than patients with SNMMs lacking lymphocyte infiltrates. Brisk TILs were associated with the lower T3 stage and increased recurrence‐free and 5‐year survival.
Conclusion
Our results indicate that TIL density is a strong prognostic factor for better survival in SNMM. Prospective studies with larger case numbers are warranted to determine whether TILs should be included in future AJCC staging guidelines.
Level of Evidence
3 Laryngoscope, 132:1334–1339, 2022</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.29820</identifier><identifier>PMID: 34415055</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Histology ; Laryngoscopy ; Lymphocytes ; Melanoma ; mucosa ; prognosis ; sinonasal ; Tumor‐infiltrating lymphocytes</subject><ispartof>The Laryngoscope, 2022-07, Vol.132 (7), p.1334-1339</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2021 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3930-640f0e5507ac0cab83fca28445e38dbd4896b3e78fc8ddbd803dab51c79fa0b73</citedby><cites>FETCH-LOGICAL-c3930-640f0e5507ac0cab83fca28445e38dbd4896b3e78fc8ddbd803dab51c79fa0b73</cites><orcidid>0000-0001-7313-2088</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.29820$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.29820$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34415055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ledderose, Stephan</creatorcontrib><creatorcontrib>Ledderose, Carola</creatorcontrib><creatorcontrib>Penkava, Josef</creatorcontrib><creatorcontrib>Ledderose, Georg J.</creatorcontrib><title>Prognostic Value of Tumor‐Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value of TILs in sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether TILs can be used as a prognostic indicator for survival in SNMM.
Study Design
Retrospective cohort study.
Methods
Patient history and histologic specimens from 27 patients with primary SNMM were retrospectively analyzed. TIL grade was determined and associations between TILs and AJCC tumor stage, overall survival, and recurrence‐free survival were analyzed.
Results
Patients with TILs in the primary tumor classified as brisk or non‐brisk survived significantly longer than patients with SNMMs lacking lymphocyte infiltrates. Brisk TILs were associated with the lower T3 stage and increased recurrence‐free and 5‐year survival.
Conclusion
Our results indicate that TIL density is a strong prognostic factor for better survival in SNMM. Prospective studies with larger case numbers are warranted to determine whether TILs should be included in future AJCC staging guidelines.
Level of Evidence
3 Laryngoscope, 132:1334–1339, 2022</description><subject>Histology</subject><subject>Laryngoscopy</subject><subject>Lymphocytes</subject><subject>Melanoma</subject><subject>mucosa</subject><subject>prognosis</subject><subject>sinonasal</subject><subject>Tumor‐infiltrating lymphocytes</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kMtKxDAUhoMoOl42PoAU3IhQPbm16XIYvMGIMl7QVUjTdOzQNmPSIrPzEXxGn8ToqAsXrn4O5-Pn50NoF8MRBiDHtXKLI5IJAitogDnFMcsyvooG4UljwcnDBtr0fgaAU8phHW1QxjAHzgdocu3stLW-q3R0r-reRLaMbvvGuvfXt4u2rOrOqa5qp9F40cyfrF50xkdVG91UrW2VV3V02Wv7laZWrW3UNlorVe3NznduobvTk9vReTy-OrsYDcexphmFOGFQguEcUqVBq1zQUisiGOOGiiIvmMiSnJpUlFoU4RZAC5VzrNOsVJCndAsdLHvnzj73xneyqbw2dVhhbO8l4QllhJOEBXT_DzqzvWvDOkmSNAkjQCSBOlxS2lnvnSnl3FVNkCsxyE_T8tO0_DId4L3vyj5vTPGL_qgNAF4CL1VtFv9UyfFw8rgs_QAuq4pv</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Ledderose, Stephan</creator><creator>Ledderose, Carola</creator><creator>Penkava, Josef</creator><creator>Ledderose, Georg J.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7313-2088</orcidid></search><sort><creationdate>202207</creationdate><title>Prognostic Value of Tumor‐Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma</title><author>Ledderose, Stephan ; Ledderose, Carola ; Penkava, Josef ; Ledderose, Georg J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3930-640f0e5507ac0cab83fca28445e38dbd4896b3e78fc8ddbd803dab51c79fa0b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Histology</topic><topic>Laryngoscopy</topic><topic>Lymphocytes</topic><topic>Melanoma</topic><topic>mucosa</topic><topic>prognosis</topic><topic>sinonasal</topic><topic>Tumor‐infiltrating lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ledderose, Stephan</creatorcontrib><creatorcontrib>Ledderose, Carola</creatorcontrib><creatorcontrib>Penkava, Josef</creatorcontrib><creatorcontrib>Ledderose, Georg J.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ledderose, Stephan</au><au>Ledderose, Carola</au><au>Penkava, Josef</au><au>Ledderose, Georg J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of Tumor‐Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2022-07</date><risdate>2022</risdate><volume>132</volume><issue>7</issue><spage>1334</spage><epage>1339</epage><pages>1334-1339</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value of TILs in sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether TILs can be used as a prognostic indicator for survival in SNMM.
Study Design
Retrospective cohort study.
Methods
Patient history and histologic specimens from 27 patients with primary SNMM were retrospectively analyzed. TIL grade was determined and associations between TILs and AJCC tumor stage, overall survival, and recurrence‐free survival were analyzed.
Results
Patients with TILs in the primary tumor classified as brisk or non‐brisk survived significantly longer than patients with SNMMs lacking lymphocyte infiltrates. Brisk TILs were associated with the lower T3 stage and increased recurrence‐free and 5‐year survival.
Conclusion
Our results indicate that TIL density is a strong prognostic factor for better survival in SNMM. Prospective studies with larger case numbers are warranted to determine whether TILs should be included in future AJCC staging guidelines.
Level of Evidence
3 Laryngoscope, 132:1334–1339, 2022</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34415055</pmid><doi>10.1002/lary.29820</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7313-2088</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Histology Laryngoscopy Lymphocytes Melanoma mucosa prognosis sinonasal Tumor‐infiltrating lymphocytes |
| title | Prognostic Value of Tumor‐Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma |
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