Characterization of Polysorbate 80 by Liquid Chromatography-Mass Spectrometry to Understand Its Susceptibility to Degradation and Its Oxidative Degradation Pathway

A liquid chromatography-mass spectrometry (LC–MS) method was developed to provide a fingerprint of polysorbate 80 (PS80) subspecies that enables identification of PS80 degradation pathway. The developed method demonstrates unique monoester peak profile of PS80 from different vendors, attributed by d...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2022-02, Vol.111 (2), p.323-334
Hauptverfasser:	Liu, Haiyan, Jin, Yutong, Menon, Rashmi, Laskowich, Erin, Bareford, Lisa, de Vilmorin, Phil, Kolwyck, Dave, Yeung, Bernice, Yi, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Chromatography, Liquid Degradants Degradation pathway Excipient Hydrolysis Liquid chromatography Mass Spectrometry Oxidation Oxidative Stress Polysorbate Polysorbates - chemistry Solid phase extraction Surfactants
Online-Zugang:	Volltext
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