RARγ activation sensitizes human myeloma cells to carfilzomib treatment through the OAS-RNase L innate immune pathway

Proteasome inhibitors (PIs) such as bortezomib (Btz) and carfilzomib (Cfz) are highly efficacious for patients with multiple myeloma (MM). However, relapses are frequent, and acquired resistance to PI treatment emerges in most patients. Here, we performed a high-throughput screen of 1855 Food and Dr...

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Veröffentlicht in:	Blood 2022-01, Vol.139 (1), p.59-72
Hauptverfasser:	Wang, Qiang, Lin, Zhijuan, Wang, Zhuo, Ye, Lingqun, Xian, Miao, Xiao, Liuling, Su, Pan, Bi, Enguang, Huang, Yung-hsing, Qian, Jianfei, Liu, Lintao, Ma, Xingzhe, Yang, Maojie, Xiong, Wei, Zu, Youli, Pingali, Sai Ravi, Xu, Bing, Yi, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - immunology Antineoplastic Agents - pharmacology Cell Line, Tumor Endoribonucleases - immunology Humans Immunity, Innate - drug effects Multiple Myeloma - drug therapy Oligopeptides - pharmacology Receptors, Retinoic Acid - agonists Receptors, Retinoic Acid - immunology Retinoic Acid Receptor gamma Tumor Cells, Cultured
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