Azurocidin is loaded into small extracellular vesicles via its N‐linked glycosylation and promotes intravasation of renal cell carcinoma cells

Azurocidin (AZU1) is an antimicrobial protein secreted by neutrophils that acts as a chemoattractant for monocytes and macrophages and a permeabilizer of vascular endothelial cells. We previously identified AZU1 to be specifically present in extracellular vesicles (EVs) obtained from renal cell carc...

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Veröffentlicht in:	FEBS letters 2021-10, Vol.595 (19), p.2522-2532
Hauptverfasser:	Naito, Takuya, Jingushi, Kentaro, Ueda, Koji, Tsujikawa, Kazutake
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism azurocidin Blood Proteins Calcium - metabolism Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Line, Tumor Endothelial Cells - metabolism Extracellular Vesicles - genetics Extracellular Vesicles - metabolism Glycosylation Human Umbilical Vein Endothelial Cells - metabolism Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology N‐linked glycosylation renal cell carcinoma small extracellular vesicles Transendothelial and Transepithelial Migration Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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