Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish
Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Ba...
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| Veröffentlicht in: | Journal of ethnopharmacology 2022-01, Vol.282, p.114546-114546, Article 114546 |
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| creator | Sharma, Mahima Gupta, Pankaj Kumar Gupta, Pankaj Garabadu, Debapriya |
| description | Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Bacopa monnieri in experimental animal model is yet to establish.
The present study was designed to evaluate the anti-nociceptive potential of standardized methanolic extract of Bacopa monnieri in experimental adult zebrafish (Danio rerio) model of pain.
The methanolic extract of Bacopa monnieri (BME) was standardized to bacoside-A using chromatographic method. Subsequently, BME (0.75, 1.25 and 5.0 mg/ml) was evaluated for anti-nociceptive activity using adult zebrafish model.
Standardized BME showed antioxidant effect through radical quenching activity in in vitro study. BME at 1.25 mg/ml significantly decreased the nociceptive effect induced by different noxious agents like acetic acid where as BME at 2.5 mg/ml exhibited significant antinociceptive activity against glutamate, formalin, capsaicin, cinnamaldehyde when compared to control and sham group animals.
BME exerted antinociceptive activity in adult zebrafish. It could be presumed that BME may involve glutamatergic receptor, ASIC and TRP channel activity in its anti-nociceptive effect. BME could be considered as a potential therapeutic option in the management of pain.
[Display omitted]
•The methanolic extract of Bacopa monnieri (BME) was standardized to Bacoside-A.•BME exhibited antinociceptive activity in acetic acid treated adult zebrafish.•BME exhibited antinociceptive activity in glutamate and formalin treated zebrafish.•BME showed antinociceptive effect in capsaicin and cinnamaldehyde treated animals.•BME could be a potential therapeutic option in the management of pain. |
| doi_str_mv | 10.1016/j.jep.2021.114546 |
| format | Article |
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The present study was designed to evaluate the anti-nociceptive potential of standardized methanolic extract of Bacopa monnieri in experimental adult zebrafish (Danio rerio) model of pain.
The methanolic extract of Bacopa monnieri (BME) was standardized to bacoside-A using chromatographic method. Subsequently, BME (0.75, 1.25 and 5.0 mg/ml) was evaluated for anti-nociceptive activity using adult zebrafish model.
Standardized BME showed antioxidant effect through radical quenching activity in in vitro study. BME at 1.25 mg/ml significantly decreased the nociceptive effect induced by different noxious agents like acetic acid where as BME at 2.5 mg/ml exhibited significant antinociceptive activity against glutamate, formalin, capsaicin, cinnamaldehyde when compared to control and sham group animals.
BME exerted antinociceptive activity in adult zebrafish. It could be presumed that BME may involve glutamatergic receptor, ASIC and TRP channel activity in its anti-nociceptive effect. BME could be considered as a potential therapeutic option in the management of pain.
[Display omitted]
•The methanolic extract of Bacopa monnieri (BME) was standardized to Bacoside-A.•BME exhibited antinociceptive activity in acetic acid treated adult zebrafish.•BME exhibited antinociceptive activity in glutamate and formalin treated zebrafish.•BME showed antinociceptive effect in capsaicin and cinnamaldehyde treated animals.•BME could be a potential therapeutic option in the management of pain.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2021.114546</identifier><identifier>PMID: 34418512</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acid Sensing Ion Channels - metabolism ; Analgesics - pharmacology ; Animals ; Antioxidants - pharmacology ; Bacopa ; Bacopa monnieri ; Brain ; Chromatography ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agents - pharmacology ; Neuralgia - drug therapy ; Neuralgia - metabolism ; Nociception ; Plant Extracts - pharmacology ; Plants, Medicinal ; Transient Receptor Potential Channels - metabolism ; Zebrafish</subject><ispartof>Journal of ethnopharmacology, 2022-01, Vol.282, p.114546-114546, Article 114546</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-de588495f8a2bd8f8716ec7d4117feb659026e917faaee381bf1503cc4a0ae633</citedby><cites>FETCH-LOGICAL-c353t-de588495f8a2bd8f8716ec7d4117feb659026e917faaee381bf1503cc4a0ae633</cites><orcidid>0000-0002-4235-3926 ; 0000-0003-0319-3672</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874121007753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34418512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Mahima</creatorcontrib><creatorcontrib>Gupta, Pankaj Kumar</creatorcontrib><creatorcontrib>Gupta, Pankaj</creatorcontrib><creatorcontrib>Garabadu, Debapriya</creatorcontrib><title>Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Bacopa monnieri in experimental animal model is yet to establish.
The present study was designed to evaluate the anti-nociceptive potential of standardized methanolic extract of Bacopa monnieri in experimental adult zebrafish (Danio rerio) model of pain.
The methanolic extract of Bacopa monnieri (BME) was standardized to bacoside-A using chromatographic method. Subsequently, BME (0.75, 1.25 and 5.0 mg/ml) was evaluated for anti-nociceptive activity using adult zebrafish model.
Standardized BME showed antioxidant effect through radical quenching activity in in vitro study. BME at 1.25 mg/ml significantly decreased the nociceptive effect induced by different noxious agents like acetic acid where as BME at 2.5 mg/ml exhibited significant antinociceptive activity against glutamate, formalin, capsaicin, cinnamaldehyde when compared to control and sham group animals.
BME exerted antinociceptive activity in adult zebrafish. It could be presumed that BME may involve glutamatergic receptor, ASIC and TRP channel activity in its anti-nociceptive effect. BME could be considered as a potential therapeutic option in the management of pain.
[Display omitted]
•The methanolic extract of Bacopa monnieri (BME) was standardized to Bacoside-A.•BME exhibited antinociceptive activity in acetic acid treated adult zebrafish.•BME exhibited antinociceptive activity in glutamate and formalin treated zebrafish.•BME showed antinociceptive effect in capsaicin and cinnamaldehyde treated animals.•BME could be a potential therapeutic option in the management of pain.</description><subject>Acid Sensing Ion Channels - metabolism</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Bacopa</subject><subject>Bacopa monnieri</subject><subject>Brain</subject><subject>Chromatography</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Excitatory Amino Acid Agents - pharmacology</subject><subject>Neuralgia - drug therapy</subject><subject>Neuralgia - metabolism</subject><subject>Nociception</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Transient Receptor Potential Channels - metabolism</subject><subject>Zebrafish</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLFuFDEQhi0URC6BB0gTbUmzh2dtr32iCqcQkCLRQG157bHw6dZebF9E8vTx6QJlqtE_881ffIRcAV0DhfHTbr3DZT3QAdYAXPDxDVmBkkMvhWRnZEWZVL2SHM7JRSk7SqkETt-Rc8Y5KAHDioSbWENMNlhcanjAztg2Qn3sku9KNdGZ7MITug7_1tyOx_0XY9NiujnFGDCHLsTOBe8xY6zdYlqck8N9ObJPOGXjQ_n9nrz1Zl_ww8u8JL--3v7cfuvvf9x9397c95YJVnuHQim-EV6ZYXLKKwkjWuk4gPQ4jWJDhxE3LRiDyBRMHgRl1nJDDY6MXZKPp94lpz8HLFXPoVjc703EdCh6ECPjA0gKDYUTanMqJaPXSw6zyY8aqD4a1jvdDOujYX0y3H6uX-oP04zu_8c_pQ34fAKaAHxofnSxAaNFFzLaql0Kr9Q_A20DjWY</recordid><startdate>20220110</startdate><enddate>20220110</enddate><creator>Sharma, Mahima</creator><creator>Gupta, Pankaj Kumar</creator><creator>Gupta, Pankaj</creator><creator>Garabadu, Debapriya</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4235-3926</orcidid><orcidid>https://orcid.org/0000-0003-0319-3672</orcidid></search><sort><creationdate>20220110</creationdate><title>Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish</title><author>Sharma, Mahima ; Gupta, Pankaj Kumar ; Gupta, Pankaj ; Garabadu, Debapriya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-de588495f8a2bd8f8716ec7d4117feb659026e917faaee381bf1503cc4a0ae633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acid Sensing Ion Channels - metabolism</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Bacopa</topic><topic>Bacopa monnieri</topic><topic>Brain</topic><topic>Chromatography</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Excitatory Amino Acid Agents - pharmacology</topic><topic>Neuralgia - drug therapy</topic><topic>Neuralgia - metabolism</topic><topic>Nociception</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Transient Receptor Potential Channels - metabolism</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Mahima</creatorcontrib><creatorcontrib>Gupta, Pankaj Kumar</creatorcontrib><creatorcontrib>Gupta, Pankaj</creatorcontrib><creatorcontrib>Garabadu, Debapriya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Mahima</au><au>Gupta, Pankaj Kumar</au><au>Gupta, Pankaj</au><au>Garabadu, Debapriya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2022-01-10</date><risdate>2022</risdate><volume>282</volume><spage>114546</spage><epage>114546</epage><pages>114546-114546</pages><artnum>114546</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Bacopa monnieri in experimental animal model is yet to establish.
The present study was designed to evaluate the anti-nociceptive potential of standardized methanolic extract of Bacopa monnieri in experimental adult zebrafish (Danio rerio) model of pain.
The methanolic extract of Bacopa monnieri (BME) was standardized to bacoside-A using chromatographic method. Subsequently, BME (0.75, 1.25 and 5.0 mg/ml) was evaluated for anti-nociceptive activity using adult zebrafish model.
Standardized BME showed antioxidant effect through radical quenching activity in in vitro study. BME at 1.25 mg/ml significantly decreased the nociceptive effect induced by different noxious agents like acetic acid where as BME at 2.5 mg/ml exhibited significant antinociceptive activity against glutamate, formalin, capsaicin, cinnamaldehyde when compared to control and sham group animals.
BME exerted antinociceptive activity in adult zebrafish. It could be presumed that BME may involve glutamatergic receptor, ASIC and TRP channel activity in its anti-nociceptive effect. BME could be considered as a potential therapeutic option in the management of pain.
[Display omitted]
•The methanolic extract of Bacopa monnieri (BME) was standardized to Bacoside-A.•BME exhibited antinociceptive activity in acetic acid treated adult zebrafish.•BME exhibited antinociceptive activity in glutamate and formalin treated zebrafish.•BME showed antinociceptive effect in capsaicin and cinnamaldehyde treated animals.•BME could be a potential therapeutic option in the management of pain.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>34418512</pmid><doi>10.1016/j.jep.2021.114546</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4235-3926</orcidid><orcidid>https://orcid.org/0000-0003-0319-3672</orcidid></addata></record> |
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| subjects | Acid Sensing Ion Channels - metabolism Analgesics - pharmacology Animals Antioxidants - pharmacology Bacopa Bacopa monnieri Brain Chromatography Disease Models, Animal Dose-Response Relationship, Drug Excitatory Amino Acid Agents - pharmacology Neuralgia - drug therapy Neuralgia - metabolism Nociception Plant Extracts - pharmacology Plants, Medicinal Transient Receptor Potential Channels - metabolism Zebrafish |
| title | Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish |
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