Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice

Metoprine increases the content of histamine in brain by inhibiting histamine N-methyltransferase (HMT), a centrally acting histamine degrading enzyme. We present data demonstrating that pretreatment with metoprine attenuates the hyperlocomotive effects of METH in mice using a multi-configuration be...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2021-10, Vol.209, p.173257-173257, Article 173257
Hauptverfasser:	Kitanaka, Nobue, Hall, F. Scott, Kobori, Shotaro, Kushihara, Sota, Oyama, Hiroyuki, Sasaoka, Yasuki, Takechi, Megumi, Tanaka, Koh-ichi, Tomita, Kazuo, Igarashi, Kento, Nishiyama, Nobuyoshi, Sato, Tomoaki, Uhl, George R., Kitanaka, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-dihydroxyphenylacetic acid Animals Behavior, Animal - drug effects Dopamine Dopamine - metabolism Drug abuse Enzyme Inhibitors - pharmacology Feeding Behavior - drug effects Histamine Histamine - metabolism Histamine N-methyltransferase Histamine N-Methyltransferase - antagonists & inhibitors Histamine neurotransmission Hypothalamus - metabolism Locomotion - drug effects Male Methamphetamine Methamphetamine - adverse effects Methamphetamine - pharmacology Metoprine Mice Mice, Inbred ICR Monoamine metabolism Nucleus Accumbens - metabolism Pyrimethamine - analogs & derivatives Pyrimethamine - pharmacology Stereotyped Behavior - drug effects Synaptic Transmission - drug effects
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