Clinical value of pediatric sepsis‐induced coagulopathy score in diagnosis of sepsis‐induced coagulopathy and prognosis in children
Background In adults, sepsis‐induced coagulopathy (SIC) is diagnosed by the SIC score, known as sepsis‐3. There is no pediatric SIC (pSIC) score at present. Objectives We proposed a pSIC scoring method and evaluated the diagnostic efficacy of the score in the diagnosis of SIC in children. Patients/M...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2021-12, Vol.19 (12), p.2930-2937 |
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| creator | Xiang, Long Ren, Hong Wang, Ying Zhang, Jian Qian, Juan Li, Biru An, Kang Fu, Lijun |
| description | Background
In adults, sepsis‐induced coagulopathy (SIC) is diagnosed by the SIC score, known as sepsis‐3. There is no pediatric SIC (pSIC) score at present.
Objectives
We proposed a pSIC scoring method and evaluated the diagnostic efficacy of the score in the diagnosis of SIC in children.
Patients/Methods
Patient data were retrospectively analyzed from Shanghai Children's Medical Center between February 2014 and January 2015. The pSIC score was modified from the SIC score. The area under ROC curve (AU‐ROC) was used to compare the prognostic values of pSIC with other scores for pediatric sepsis‐induced disseminated intravascular coagulation (DIC) to arrive at a 28‐day outcome.
Results and Conclusions
There were 54 patients in the pSIC group and 37 in the non‐pSIC group. The Kaplan–Meier survival curve analysis showed that the 28‐day prognosis was better in the non‐pSIC than in the pSIC group (p 3 inferior to that of pediatric sequential organ failure (0.716 vs. 0.921, p 3. The AU‐ROC of pSIC in predicting overt DIC was 0.901, with the best optimal cutoff value of >4. The pSIC score can be used to diagnose SIC in children, screen potential nonovert DIC, and assess the severity of sepsis, organ dysfunction, and 28‐day outcome in children. |
| doi_str_mv | 10.1111/jth.15500 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2562831918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2598843252</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3530-1687c23c674234921c75ff50dd3653b7dd8a92503a4e5e9f3188572030297b623</originalsourceid><addsrcrecordid>eNp90b1OwzAUBWALgfgfeAFkiQWGFts3TpwRVUBBSCxljlzboa7cONgNqBsbK8_Ik-DSwoAEXq6H7x5d6SB0REmfpnc-nU_6lHNCNtAu5SB6hYB88_tfAuygvRinhNCSM7KNdiDLSMFzsYveBs42VkmHn6XrDPY1bo22ch6swtG00caP13fb6E4ZjZWXj53zrZxPFjgqHwy2DU78sfFJLrf_35GNxm3wa5521cQ6HUxzgLZq6aI5XM999HB1ORoMe3f31zeDi7ueAg6kR3NRKAYqLzIGWcmoKnhdc6I15BzGhdZClowTkJnhpqyBCsELRoCwshjnDPbR6So3XfHUmTivZjYq45xsjO9ixXjOBNCSikRPftGp70KTrkuqFCIDxpeBZyulgo8xmLpqg53JsKgoqZbtVKmd6qudZI_Xid14ZvSP_K4jgfMVeLHOLP5Oqm5Hw1XkJy4Tm70</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2598843252</pqid></control><display><type>article</type><title>Clinical value of pediatric sepsis‐induced coagulopathy score in diagnosis of sepsis‐induced coagulopathy and prognosis in children</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Xiang, Long ; Ren, Hong ; Wang, Ying ; Zhang, Jian ; Qian, Juan ; Li, Biru ; An, Kang ; Fu, Lijun</creator><creatorcontrib>Xiang, Long ; Ren, Hong ; Wang, Ying ; Zhang, Jian ; Qian, Juan ; Li, Biru ; An, Kang ; Fu, Lijun</creatorcontrib><description>Background
In adults, sepsis‐induced coagulopathy (SIC) is diagnosed by the SIC score, known as sepsis‐3. There is no pediatric SIC (pSIC) score at present.
Objectives
We proposed a pSIC scoring method and evaluated the diagnostic efficacy of the score in the diagnosis of SIC in children.
Patients/Methods
Patient data were retrospectively analyzed from Shanghai Children's Medical Center between February 2014 and January 2015. The pSIC score was modified from the SIC score. The area under ROC curve (AU‐ROC) was used to compare the prognostic values of pSIC with other scores for pediatric sepsis‐induced disseminated intravascular coagulation (DIC) to arrive at a 28‐day outcome.
Results and Conclusions
There were 54 patients in the pSIC group and 37 in the non‐pSIC group. The Kaplan–Meier survival curve analysis showed that the 28‐day prognosis was better in the non‐pSIC than in the pSIC group (p < .001). The AU‐ROC of the pSIC score in predicting 28‐day mortality in sepsis was 0.716, with the optimal cutoff value of >3 inferior to that of pediatric sequential organ failure (0.716 vs. 0.921, p < .001). The AU‐ROC of pSIC in predicting nonovert DIC was 0.845 and the optimal cutoff value was >3. The AU‐ROC of pSIC in predicting overt DIC was 0.901, with the best optimal cutoff value of >4. The pSIC score can be used to diagnose SIC in children, screen potential nonovert DIC, and assess the severity of sepsis, organ dysfunction, and 28‐day outcome in children.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/jth.15500</identifier><identifier>PMID: 34407568</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Child ; Children ; China ; Diagnosis ; Disseminated intravascular coagulation ; Disseminated Intravascular Coagulation - diagnosis ; Humans ; Medical prognosis ; Patients ; Pediatrics ; Prognosis ; Retrospective Studies ; Sepsis ; Sepsis - complications ; Sepsis - diagnosis ; sepsis‐induced coagulopathy ; Sequential Organ Failure Assessment</subject><ispartof>Journal of thrombosis and haemostasis, 2021-12, Vol.19 (12), p.2930-2937</ispartof><rights>2021 International Society on Thrombosis and Haemostasis</rights><rights>2021 International Society on Thrombosis and Haemostasis.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-1687c23c674234921c75ff50dd3653b7dd8a92503a4e5e9f3188572030297b623</citedby><cites>FETCH-LOGICAL-c3530-1687c23c674234921c75ff50dd3653b7dd8a92503a4e5e9f3188572030297b623</cites><orcidid>0000-0003-0276-9115</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34407568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiang, Long</creatorcontrib><creatorcontrib>Ren, Hong</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Qian, Juan</creatorcontrib><creatorcontrib>Li, Biru</creatorcontrib><creatorcontrib>An, Kang</creatorcontrib><creatorcontrib>Fu, Lijun</creatorcontrib><title>Clinical value of pediatric sepsis‐induced coagulopathy score in diagnosis of sepsis‐induced coagulopathy and prognosis in children</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>Background
In adults, sepsis‐induced coagulopathy (SIC) is diagnosed by the SIC score, known as sepsis‐3. There is no pediatric SIC (pSIC) score at present.
Objectives
We proposed a pSIC scoring method and evaluated the diagnostic efficacy of the score in the diagnosis of SIC in children.
Patients/Methods
Patient data were retrospectively analyzed from Shanghai Children's Medical Center between February 2014 and January 2015. The pSIC score was modified from the SIC score. The area under ROC curve (AU‐ROC) was used to compare the prognostic values of pSIC with other scores for pediatric sepsis‐induced disseminated intravascular coagulation (DIC) to arrive at a 28‐day outcome.
Results and Conclusions
There were 54 patients in the pSIC group and 37 in the non‐pSIC group. The Kaplan–Meier survival curve analysis showed that the 28‐day prognosis was better in the non‐pSIC than in the pSIC group (p < .001). The AU‐ROC of the pSIC score in predicting 28‐day mortality in sepsis was 0.716, with the optimal cutoff value of >3 inferior to that of pediatric sequential organ failure (0.716 vs. 0.921, p < .001). The AU‐ROC of pSIC in predicting nonovert DIC was 0.845 and the optimal cutoff value was >3. The AU‐ROC of pSIC in predicting overt DIC was 0.901, with the best optimal cutoff value of >4. The pSIC score can be used to diagnose SIC in children, screen potential nonovert DIC, and assess the severity of sepsis, organ dysfunction, and 28‐day outcome in children.</description><subject>Child</subject><subject>Children</subject><subject>China</subject><subject>Diagnosis</subject><subject>Disseminated intravascular coagulation</subject><subject>Disseminated Intravascular Coagulation - diagnosis</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sepsis</subject><subject>Sepsis - complications</subject><subject>Sepsis - diagnosis</subject><subject>sepsis‐induced coagulopathy</subject><subject>Sequential Organ Failure Assessment</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90b1OwzAUBWALgfgfeAFkiQWGFts3TpwRVUBBSCxljlzboa7cONgNqBsbK8_Ik-DSwoAEXq6H7x5d6SB0REmfpnc-nU_6lHNCNtAu5SB6hYB88_tfAuygvRinhNCSM7KNdiDLSMFzsYveBs42VkmHn6XrDPY1bo22ch6swtG00caP13fb6E4ZjZWXj53zrZxPFjgqHwy2DU78sfFJLrf_35GNxm3wa5521cQ6HUxzgLZq6aI5XM999HB1ORoMe3f31zeDi7ueAg6kR3NRKAYqLzIGWcmoKnhdc6I15BzGhdZClowTkJnhpqyBCsELRoCwshjnDPbR6So3XfHUmTivZjYq45xsjO9ixXjOBNCSikRPftGp70KTrkuqFCIDxpeBZyulgo8xmLpqg53JsKgoqZbtVKmd6qudZI_Xid14ZvSP_K4jgfMVeLHOLP5Oqm5Hw1XkJy4Tm70</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Xiang, Long</creator><creator>Ren, Hong</creator><creator>Wang, Ying</creator><creator>Zhang, Jian</creator><creator>Qian, Juan</creator><creator>Li, Biru</creator><creator>An, Kang</creator><creator>Fu, Lijun</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0276-9115</orcidid></search><sort><creationdate>202112</creationdate><title>Clinical value of pediatric sepsis‐induced coagulopathy score in diagnosis of sepsis‐induced coagulopathy and prognosis in children</title><author>Xiang, Long ; Ren, Hong ; Wang, Ying ; Zhang, Jian ; Qian, Juan ; Li, Biru ; An, Kang ; Fu, Lijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-1687c23c674234921c75ff50dd3653b7dd8a92503a4e5e9f3188572030297b623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Child</topic><topic>Children</topic><topic>China</topic><topic>Diagnosis</topic><topic>Disseminated intravascular coagulation</topic><topic>Disseminated Intravascular Coagulation - diagnosis</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sepsis</topic><topic>Sepsis - complications</topic><topic>Sepsis - diagnosis</topic><topic>sepsis‐induced coagulopathy</topic><topic>Sequential Organ Failure Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiang, Long</creatorcontrib><creatorcontrib>Ren, Hong</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Qian, Juan</creatorcontrib><creatorcontrib>Li, Biru</creatorcontrib><creatorcontrib>An, Kang</creatorcontrib><creatorcontrib>Fu, Lijun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiang, Long</au><au>Ren, Hong</au><au>Wang, Ying</au><au>Zhang, Jian</au><au>Qian, Juan</au><au>Li, Biru</au><au>An, Kang</au><au>Fu, Lijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical value of pediatric sepsis‐induced coagulopathy score in diagnosis of sepsis‐induced coagulopathy and prognosis in children</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2021-12</date><risdate>2021</risdate><volume>19</volume><issue>12</issue><spage>2930</spage><epage>2937</epage><pages>2930-2937</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>Background
In adults, sepsis‐induced coagulopathy (SIC) is diagnosed by the SIC score, known as sepsis‐3. There is no pediatric SIC (pSIC) score at present.
Objectives
We proposed a pSIC scoring method and evaluated the diagnostic efficacy of the score in the diagnosis of SIC in children.
Patients/Methods
Patient data were retrospectively analyzed from Shanghai Children's Medical Center between February 2014 and January 2015. The pSIC score was modified from the SIC score. The area under ROC curve (AU‐ROC) was used to compare the prognostic values of pSIC with other scores for pediatric sepsis‐induced disseminated intravascular coagulation (DIC) to arrive at a 28‐day outcome.
Results and Conclusions
There were 54 patients in the pSIC group and 37 in the non‐pSIC group. The Kaplan–Meier survival curve analysis showed that the 28‐day prognosis was better in the non‐pSIC than in the pSIC group (p < .001). The AU‐ROC of the pSIC score in predicting 28‐day mortality in sepsis was 0.716, with the optimal cutoff value of >3 inferior to that of pediatric sequential organ failure (0.716 vs. 0.921, p < .001). The AU‐ROC of pSIC in predicting nonovert DIC was 0.845 and the optimal cutoff value was >3. The AU‐ROC of pSIC in predicting overt DIC was 0.901, with the best optimal cutoff value of >4. The pSIC score can be used to diagnose SIC in children, screen potential nonovert DIC, and assess the severity of sepsis, organ dysfunction, and 28‐day outcome in children.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>34407568</pmid><doi>10.1111/jth.15500</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0276-9115</orcidid></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Child Children China Diagnosis Disseminated intravascular coagulation Disseminated Intravascular Coagulation - diagnosis Humans Medical prognosis Patients Pediatrics Prognosis Retrospective Studies Sepsis Sepsis - complications Sepsis - diagnosis sepsis‐induced coagulopathy Sequential Organ Failure Assessment |
| title | Clinical value of pediatric sepsis‐induced coagulopathy score in diagnosis of sepsis‐induced coagulopathy and prognosis in children |
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