RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

Acute myeloid leukemia (AML) is a rapidly progressing cancer, for which chemotherapy remains standard treatment and additional therapeutic targets are requisite. Here, we show that AML cells secrete the stem cell growth factor R-spondin 2 (RSPO2) to promote their self-renewal and prevent cell differ...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-08, Vol.36 (7), p.109559-109559, Article 109559
Hauptverfasser:	Sun, Rui, He, Lixiazi, Lee, Hyeyoon, Glinka, Andrey, Andresen, Carolin, Hübschmann, Daniel, Jeremias, Irmela, Müller-Decker, Karin, Pabst, Caroline, Niehrs, Christof
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia Animals Autocrine Communication - drug effects BMP Bone Morphogenetic Proteins - metabolism Cell Differentiation - drug effects Cell Self Renewal - drug effects Cytarabine - pharmacology drug resistance HEK293 Cells Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism HSPC Humans Intercellular Signaling Peptides and Proteins - metabolism leukemia stem cell Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology macrophages Mice monocytes Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Prognosis R-spondin Risk Factors self-renewal Signal Transduction - drug effects Survival Analysis WNT Xenograft Model Antitumor Assays
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