Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials
Recent studies have reported conflicting findings on the antianxiety, antidepressant, and anti‐stress properties of Rosa Damascena Mill (RDM). Therefore, the present systematic review and meta‐analysis were conducted on the effects of RDM for treating anxiety, depression, and stress amongst adults....
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| Veröffentlicht in: | Phytotherapy research 2021-12, Vol.35 (12), p.6585-6606 |
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| creator | Rasooli, Taravat Nasiri, Morteza Kargarzadeh Aliabadi, Zeynab Rajabi, Mohammad Reza Feizi, Shahoo Torkaman, Mahya Keyvanloo Shahrestanaki, Sahar Mohsenikhah, Meisam Rezaei, Masoud Abbasi, Mohammad |
| description | Recent studies have reported conflicting findings on the antianxiety, antidepressant, and anti‐stress properties of Rosa Damascena Mill (RDM). Therefore, the present systematic review and meta‐analysis were conducted on the effects of RDM for treating anxiety, depression, and stress amongst adults. The online data sources of Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science, Embase, ProQuest, and Scientific Information Database were searched from inception to June 30, 2021. The randomized controlled trials (RCTs), which examined the effects of RDM (in any form of administration) on adults' anxiety, depression, and stress, were included. A random‐effects model was applied to pool the data, and a total of 32 publications were included. The results of the meta‐analysis revealed that administration of RDM significantly reduced state anxiety (effect size [ES]: 24, standardized mean difference [SMD]: −1.74, 95% confidence interval [CI]: −2.29, −1.20; p |
| doi_str_mv | 10.1002/ptr.7243 |
| format | Article |
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Therefore, the present systematic review and meta‐analysis were conducted on the effects of RDM for treating anxiety, depression, and stress amongst adults. The online data sources of Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science, Embase, ProQuest, and Scientific Information Database were searched from inception to June 30, 2021. The randomized controlled trials (RCTs), which examined the effects of RDM (in any form of administration) on adults' anxiety, depression, and stress, were included. A random‐effects model was applied to pool the data, and a total of 32 publications were included. The results of the meta‐analysis revealed that administration of RDM significantly reduced state anxiety (effect size [ES]: 24, standardized mean difference [SMD]: −1.74, 95% confidence interval [CI]: −2.29, −1.20; p < .001), depression (ES: 7, SMD: −0.87, 95% CI: −1.47, −0.28; p = .004), and stress (ES: 4, SMD: −1.33, 95% CI: −1.98, −0.69; p < .001). However, the treatment had no significant effect on trait anxiety (ES: 6, weighted mean difference: −0.75, 95% CI: −1.93, 0.43; p = .214). The association between the total administration dosage and/or duration of RDM and the changes in state anxiety and depression was not dose‐dependent. Most RCTs had a fair methodological quality based on the Cochrane risk of bias assessment tool. Besides, the quality of evidence ranged from very low to moderate according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Hence, further high‐quality RCTs are needed to draw reliable conclusions regarding the use of RDM for treating adults' anxiety, depression, and stress.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7243</identifier><identifier>PMID: 34405933</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Adults ; Antidepressants ; Anxiety ; Anxiety - drug therapy ; Anxiety Disorders - drug therapy ; Clinical trials ; Confidence intervals ; damask rose ; depression ; Depression - drug therapy ; Humans ; Mental depression ; Meta-analysis ; Quality ; Randomized Controlled Trials as Topic ; Rosa ; Rosa Damascena ; Stress ; stress disorders ; Systematic review</subject><ispartof>Phytotherapy research, 2021-12, Vol.35 (12), p.6585-6606</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2021 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3493-cf088ec1d47e1e6d0b6bfb5d4ce914e0e27866ef0cd962ddc90257e7b04362743</citedby><cites>FETCH-LOGICAL-c3493-cf088ec1d47e1e6d0b6bfb5d4ce914e0e27866ef0cd962ddc90257e7b04362743</cites><orcidid>0000-0003-1698-5281</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7243$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7243$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34405933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasooli, Taravat</creatorcontrib><creatorcontrib>Nasiri, Morteza</creatorcontrib><creatorcontrib>Kargarzadeh Aliabadi, Zeynab</creatorcontrib><creatorcontrib>Rajabi, Mohammad Reza</creatorcontrib><creatorcontrib>Feizi, Shahoo</creatorcontrib><creatorcontrib>Torkaman, Mahya</creatorcontrib><creatorcontrib>Keyvanloo Shahrestanaki, Sahar</creatorcontrib><creatorcontrib>Mohsenikhah, Meisam</creatorcontrib><creatorcontrib>Rezaei, Masoud</creatorcontrib><creatorcontrib>Abbasi, Mohammad</creatorcontrib><title>Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>Recent studies have reported conflicting findings on the antianxiety, antidepressant, and anti‐stress properties of Rosa Damascena Mill (RDM). Therefore, the present systematic review and meta‐analysis were conducted on the effects of RDM for treating anxiety, depression, and stress amongst adults. The online data sources of Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science, Embase, ProQuest, and Scientific Information Database were searched from inception to June 30, 2021. The randomized controlled trials (RCTs), which examined the effects of RDM (in any form of administration) on adults' anxiety, depression, and stress, were included. A random‐effects model was applied to pool the data, and a total of 32 publications were included. The results of the meta‐analysis revealed that administration of RDM significantly reduced state anxiety (effect size [ES]: 24, standardized mean difference [SMD]: −1.74, 95% confidence interval [CI]: −2.29, −1.20; p < .001), depression (ES: 7, SMD: −0.87, 95% CI: −1.47, −0.28; p = .004), and stress (ES: 4, SMD: −1.33, 95% CI: −1.98, −0.69; p < .001). However, the treatment had no significant effect on trait anxiety (ES: 6, weighted mean difference: −0.75, 95% CI: −1.93, 0.43; p = .214). The association between the total administration dosage and/or duration of RDM and the changes in state anxiety and depression was not dose‐dependent. Most RCTs had a fair methodological quality based on the Cochrane risk of bias assessment tool. Besides, the quality of evidence ranged from very low to moderate according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Hence, further high‐quality RCTs are needed to draw reliable conclusions regarding the use of RDM for treating adults' anxiety, depression, and stress.</description><subject>Adult</subject><subject>Adults</subject><subject>Antidepressants</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety Disorders - drug therapy</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>damask rose</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Humans</subject><subject>Mental depression</subject><subject>Meta-analysis</subject><subject>Quality</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Rosa</subject><subject>Rosa Damascena</subject><subject>Stress</subject><subject>stress disorders</subject><subject>Systematic review</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9q1zAUx4Mo7ucUfAIJeKEX60zStGm9G_MvDDbGBO9KmpxKRtrUnNRZr_YIgk_gq-1JzG-bCoJX5yTnkw-cfAl5zNk-Z0y8mFPcV0KWd8iGs7YteKXKu2TD2ooXkjcfd8gDxHPGWCuYvE92SilZ1Zblhvw8DajpKz1qNDBpOjrv6RAiTRF0ctMnqu3iEz6jevrqIK171MIcAdGFaS9fWoppe3xJDyiumGDMzwyN8MXBxfXcBoSryx8ZmsOEQEdI-uryu560X9EhDQONmQuj-waWmjClGLzPbYpOe3xI7g25wKPbuks-vHl9dviuODp--_7w4KgwpWzLwgysacBwKxVwqC3r637oKysNtFwCA6GauoaBGdvWwlrTMlEpUD2TZS2ULHfJ8xvvHMPnBTB1o8t_4r2eICzYiaoWFVd1ozL69B_0PCwx75OpmgsplKqqv0ITA2KEoZujG3VcO866bWxdjq3bxpbRJ7fCpR_B_gF_55SB4ga4cB7W_4q6k7PTa-EvdWymPw</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Rasooli, Taravat</creator><creator>Nasiri, Morteza</creator><creator>Kargarzadeh Aliabadi, Zeynab</creator><creator>Rajabi, Mohammad Reza</creator><creator>Feizi, Shahoo</creator><creator>Torkaman, Mahya</creator><creator>Keyvanloo Shahrestanaki, Sahar</creator><creator>Mohsenikhah, Meisam</creator><creator>Rezaei, Masoud</creator><creator>Abbasi, Mohammad</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1698-5281</orcidid></search><sort><creationdate>202112</creationdate><title>Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials</title><author>Rasooli, Taravat ; 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Therefore, the present systematic review and meta‐analysis were conducted on the effects of RDM for treating anxiety, depression, and stress amongst adults. The online data sources of Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science, Embase, ProQuest, and Scientific Information Database were searched from inception to June 30, 2021. The randomized controlled trials (RCTs), which examined the effects of RDM (in any form of administration) on adults' anxiety, depression, and stress, were included. A random‐effects model was applied to pool the data, and a total of 32 publications were included. The results of the meta‐analysis revealed that administration of RDM significantly reduced state anxiety (effect size [ES]: 24, standardized mean difference [SMD]: −1.74, 95% confidence interval [CI]: −2.29, −1.20; p < .001), depression (ES: 7, SMD: −0.87, 95% CI: −1.47, −0.28; p = .004), and stress (ES: 4, SMD: −1.33, 95% CI: −1.98, −0.69; p < .001). However, the treatment had no significant effect on trait anxiety (ES: 6, weighted mean difference: −0.75, 95% CI: −1.93, 0.43; p = .214). The association between the total administration dosage and/or duration of RDM and the changes in state anxiety and depression was not dose‐dependent. Most RCTs had a fair methodological quality based on the Cochrane risk of bias assessment tool. Besides, the quality of evidence ranged from very low to moderate according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Hence, further high‐quality RCTs are needed to draw reliable conclusions regarding the use of RDM for treating adults' anxiety, depression, and stress.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>34405933</pmid><doi>10.1002/ptr.7243</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0003-1698-5281</orcidid></addata></record> |
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| subjects | Adult Adults Antidepressants Anxiety Anxiety - drug therapy Anxiety Disorders - drug therapy Clinical trials Confidence intervals damask rose depression Depression - drug therapy Humans Mental depression Meta-analysis Quality Randomized Controlled Trials as Topic Rosa Rosa Damascena Stress stress disorders Systematic review |
| title | Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials |
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