miR-128 participates in the pathogenesis of chronic constipation by regulating the p38 alpha/M-CSF inflammatory signaling pathway

Chronic constipation (CC) is a gastrointestinal disorder that adversely affects the quality of life. MicroRNAs are involved in the pathogenesis of functional gastrointestinal disorders. This study aims to investigate the molecular mechanism of microRNA-128 in CC. Here, we successfully constructed a...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2021-10, Vol.321 (4), p.G436-G447
Hauptverfasser:	Hong, Yuntian, Ren, Xianghai, Liu, Weicheng, Sun, Kongliang, Chen, Baoxiang, Liu, Bo, Yu, Xueqiao, Chen, Quanjiao, Qian, Qun, Xie, Xiaoyu, Jiang, Congqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Cerebrospinal fluid Colony-stimulating factor Constipation Cytokines Epithelial cells Gastroenterology & Hepatology Gastrointestinal diseases Inflammation Interleukin 6 Life Sciences & Biomedicine Macrophage colony-stimulating factor Macrophages Microenvironments MicroRNAs miRNA Morphine Pathogenesis Phosphopyruvate hydratase Physiology Quality of life Science & Technology Signal transduction Stem cell factor Stem cells Therapeutic targets Tumor necrosis factor-α
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