Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time
Chromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of...
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| Veröffentlicht in: | Journal of dermatology 2021-10, Vol.48 (10), p.1612-1615 |
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| creator | Belda, Walter Casolato, Ana Thereza Stradioto Luppi, Juliana Bronzato Passero, Luiz Felipe Domingues |
| description | Chromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM. |
| doi_str_mv | 10.1111/1346-8138.16101 |
| format | Article |
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Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. 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Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM.</description><subject>acitretin</subject><subject>Acitretin - therapeutic use</subject><subject>Antiviral drugs</subject><subject>Case reports</subject><subject>chromoblastomycosis</subject><subject>Chromoblastomycosis - drug therapy</subject><subject>Chromomycosis</subject><subject>Drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Imiquimod</subject><subject>Imiquimod - therapeutic use</subject><subject>Infectious diseases</subject><subject>lesion evolution</subject><subject>Lesions</subject><subject>Patients</subject><subject>treatment</subject><subject>Vitamin A</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEUhonR2Gt17c6QuHEzLQwwH-6a2vqRGje6JlzmTC_NALfA2Nwf4v_tmU7two1sCIfnfTmHl5C3nJ1wXKdcyKbquOhOeMMZf0Y2T5XnZMNEp6pasvaIvMr5hrG6V5y9JEdCSqaklBvy57sJ5tqFa2p3Kfq4nUwu0R9szC7TO1d21FhXEhQX6H6aM3Xe3c7Ox-EjPaPWZKAJ9jEVGgMtO8D7fYq_wUPA0kjtXEyAiMIJsoshUxMGlAyzLXhckEWFL5jyoCnOw2vyYjRThjeP-zH5dXnx8_xLdfXj89fzs6vKCpyk2naCDTjfOEoQdjAGWgNbizPKljcgmlZIboxScuh530LXNowpy_q643JQvTgmH1ZfbPl2hly0d9nCNK0t61o1teKqaRii7_9Bb-KcAnaHVNvhb3atQOp0pWyKOScY9T45b9JBc6aXxPSSj17y0Q-JoeLdo--89TA88X8jQkCtwJ2b4PA_P_3t08VqfA-GqqHA</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Belda, Walter</creator><creator>Casolato, Ana Thereza Stradioto</creator><creator>Luppi, Juliana Bronzato</creator><creator>Passero, Luiz Felipe Domingues</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0401-1885</orcidid><orcidid>https://orcid.org/0000-0002-5986-6381</orcidid></search><sort><creationdate>202110</creationdate><title>Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time</title><author>Belda, Walter ; Casolato, Ana Thereza Stradioto ; Luppi, Juliana Bronzato ; Passero, Luiz Felipe Domingues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3951-b830d240ff4e3cdaae7aebc5104716e367341aa554d9197e876005c092814d593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>acitretin</topic><topic>Acitretin - therapeutic use</topic><topic>Antiviral drugs</topic><topic>Case reports</topic><topic>chromoblastomycosis</topic><topic>Chromoblastomycosis - drug therapy</topic><topic>Chromomycosis</topic><topic>Drug therapy</topic><topic>Drug Therapy, Combination</topic><topic>Fungal infections</topic><topic>Humans</topic><topic>Imiquimod</topic><topic>Imiquimod - therapeutic use</topic><topic>Infectious diseases</topic><topic>lesion evolution</topic><topic>Lesions</topic><topic>Patients</topic><topic>treatment</topic><topic>Vitamin A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belda, Walter</creatorcontrib><creatorcontrib>Casolato, Ana Thereza Stradioto</creatorcontrib><creatorcontrib>Luppi, Juliana Bronzato</creatorcontrib><creatorcontrib>Passero, Luiz Felipe Domingues</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belda, Walter</au><au>Casolato, Ana Thereza Stradioto</au><au>Luppi, Juliana Bronzato</au><au>Passero, Luiz Felipe Domingues</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2021-10</date><risdate>2021</risdate><volume>48</volume><issue>10</issue><spage>1612</spage><epage>1615</epage><pages>1612-1615</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Chromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acitretin Acitretin - therapeutic use Antiviral drugs Case reports chromoblastomycosis Chromoblastomycosis - drug therapy Chromomycosis Drug therapy Drug Therapy, Combination Fungal infections Humans Imiquimod Imiquimod - therapeutic use Infectious diseases lesion evolution Lesions Patients treatment Vitamin A |
| title | Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
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