Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue
Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2021-08, Vol.15 (8), p.e0009692-e0009692 |
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| creator | Wisanuvej, Kantasit Boonyawat, Kochawan Savetamornkul, Chutchaiwat Virapongsiri, Sirapong Krongvorakul, Jatupon Sungkanuparph, Somnuek Phuphuakrat, Angsana |
| description | Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p |
| doi_str_mv | 10.1371/journal.pntd.0009692 |
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| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_proquest_miscellaneous_2562237785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A673927687</galeid><doaj_id>oai_doaj_org_article_312c17243af040878fa0dadf5f191797</doaj_id><sourcerecordid>A673927687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c601t-162c3563332dc18c843044eef82762c0904a2a27fad215e37449c66fea1999063</originalsourceid><addsrcrecordid>eNptkstq3DAUhk1padK0b1CooVC6malutqRNIQy9BALdtGuhkY5nNMiSa8kJeYa8dOWMWzIleCGj851P0uGvqrcYrTHl-NMhTmPQfj2EbNcIIdlK8qw6x5I2K8Jp8_zR_1n1KqUDQo1sBH5ZnVFGpRCCnFf3m9gPenQphnoL-RagrD5GW--hjzsfty7UJgYDIY86u4JZyDD2LoCtt3f1EF3Iq9itjB6h1G6cgVoHW5r6wRd00Zk4hVwXmbaTz_VQXEWZ6luX96Ut7CZ4Xb3otE_wZlkvql9fv_zcfF9d__h2tbm8XpkW4bzCLTG0aSmlxBosjGAUMQbQCcJLCUnENNGEd9oS3ADljEnTth1oLKVELb2o3h29g49JLXNMijScsqZhghfi6kjYqA9qGF2vxzsVtVMPG3HcKT1mZzwoionBnDCqO8SQ4KLTyGrbNR2WmMvZ9Xk5bdr2YI-D9CfS00pwe7WLN0pQIQXDRfBxEYzx9wQpq94lA97rAHGa790SQjkXTUHf_4c-_bqF2unyABe6WM41s1RdtpzKMsYHav0EVT4LvSuJgM6V_ZOGD48a9qB93qfopzk06RRkR9CMMaURun_DwEjN2f57azVnWy3Zpn8AhPrtUQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2573455487</pqid></control><display><type>article</type><title>Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><creator>Wisanuvej, Kantasit ; Boonyawat, Kochawan ; Savetamornkul, Chutchaiwat ; Virapongsiri, Sirapong ; Krongvorakul, Jatupon ; Sungkanuparph, Somnuek ; Phuphuakrat, Angsana</creator><contributor>Diemert, David Joseph</contributor><creatorcontrib>Wisanuvej, Kantasit ; Boonyawat, Kochawan ; Savetamornkul, Chutchaiwat ; Virapongsiri, Sirapong ; Krongvorakul, Jatupon ; Sungkanuparph, Somnuek ; Phuphuakrat, Angsana ; Diemert, David Joseph</creatorcontrib><description>Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb [greater than or equal to]20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively. Conclusions Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb testing can decrease the frequency of venipuncture. Further study in children is encouraged.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0009692</identifier><identifier>PMID: 34398882</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Agreements ; Anemia ; Automation ; Biology and Life Sciences ; Biosensors ; Bleeding ; Blood ; Blood & organ donations ; Blood levels ; Blood tests ; Correlation ; Dengue ; Dengue fever ; Dengue hemorrhagic fever ; Diagnosis ; Evaluation ; Fever ; Hematocrit ; Hemoglobin ; Hospitals ; Human diseases ; Infections ; Laboratories ; Measurement ; Medicine and Health Sciences ; Monitoring ; Patients ; Physicians ; Plasma ; Sensitivity ; Software ; Specificity ; Telemedicine ; Testing ; Tropical diseases ; Vector-borne diseases</subject><ispartof>PLoS neglected tropical diseases, 2021-08, Vol.15 (8), p.e0009692-e0009692</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Wisanuvej et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Wisanuvej et al 2021 Wisanuvej et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-162c3563332dc18c843044eef82762c0904a2a27fad215e37449c66fea1999063</citedby><cites>FETCH-LOGICAL-c601t-162c3563332dc18c843044eef82762c0904a2a27fad215e37449c66fea1999063</cites><orcidid>0000-0003-1709-8772 ; 0000-0002-1055-2963 ; 0000-0003-2474-1850 ; 0000-0001-9996-6013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389841/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389841/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Diemert, David Joseph</contributor><creatorcontrib>Wisanuvej, Kantasit</creatorcontrib><creatorcontrib>Boonyawat, Kochawan</creatorcontrib><creatorcontrib>Savetamornkul, Chutchaiwat</creatorcontrib><creatorcontrib>Virapongsiri, Sirapong</creatorcontrib><creatorcontrib>Krongvorakul, Jatupon</creatorcontrib><creatorcontrib>Sungkanuparph, Somnuek</creatorcontrib><creatorcontrib>Phuphuakrat, Angsana</creatorcontrib><title>Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue</title><title>PLoS neglected tropical diseases</title><description>Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb [greater than or equal to]20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively. Conclusions Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb testing can decrease the frequency of venipuncture. Further study in children is encouraged.</description><subject>Agreements</subject><subject>Anemia</subject><subject>Automation</subject><subject>Biology and Life Sciences</subject><subject>Biosensors</subject><subject>Bleeding</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood levels</subject><subject>Blood tests</subject><subject>Correlation</subject><subject>Dengue</subject><subject>Dengue fever</subject><subject>Dengue hemorrhagic fever</subject><subject>Diagnosis</subject><subject>Evaluation</subject><subject>Fever</subject><subject>Hematocrit</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Human diseases</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Measurement</subject><subject>Medicine and Health Sciences</subject><subject>Monitoring</subject><subject>Patients</subject><subject>Physicians</subject><subject>Plasma</subject><subject>Sensitivity</subject><subject>Software</subject><subject>Specificity</subject><subject>Telemedicine</subject><subject>Testing</subject><subject>Tropical diseases</subject><subject>Vector-borne diseases</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptkstq3DAUhk1padK0b1CooVC6malutqRNIQy9BALdtGuhkY5nNMiSa8kJeYa8dOWMWzIleCGj851P0uGvqrcYrTHl-NMhTmPQfj2EbNcIIdlK8qw6x5I2K8Jp8_zR_1n1KqUDQo1sBH5ZnVFGpRCCnFf3m9gPenQphnoL-RagrD5GW--hjzsfty7UJgYDIY86u4JZyDD2LoCtt3f1EF3Iq9itjB6h1G6cgVoHW5r6wRd00Zk4hVwXmbaTz_VQXEWZ6luX96Ut7CZ4Xb3otE_wZlkvql9fv_zcfF9d__h2tbm8XpkW4bzCLTG0aSmlxBosjGAUMQbQCcJLCUnENNGEd9oS3ADljEnTth1oLKVELb2o3h29g49JLXNMijScsqZhghfi6kjYqA9qGF2vxzsVtVMPG3HcKT1mZzwoionBnDCqO8SQ4KLTyGrbNR2WmMvZ9Xk5bdr2YI-D9CfS00pwe7WLN0pQIQXDRfBxEYzx9wQpq94lA97rAHGa790SQjkXTUHf_4c-_bqF2unyABe6WM41s1RdtpzKMsYHav0EVT4LvSuJgM6V_ZOGD48a9qB93qfopzk06RRkR9CMMaURun_DwEjN2f57azVnWy3Zpn8AhPrtUQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Wisanuvej, Kantasit</creator><creator>Boonyawat, Kochawan</creator><creator>Savetamornkul, Chutchaiwat</creator><creator>Virapongsiri, Sirapong</creator><creator>Krongvorakul, Jatupon</creator><creator>Sungkanuparph, Somnuek</creator><creator>Phuphuakrat, Angsana</creator><general>Public Library of Science</general><general>Public Library of Science 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between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue</title><author>Wisanuvej, Kantasit ; Boonyawat, Kochawan ; Savetamornkul, Chutchaiwat ; Virapongsiri, Sirapong ; Krongvorakul, Jatupon ; Sungkanuparph, Somnuek ; Phuphuakrat, Angsana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-162c3563332dc18c843044eef82762c0904a2a27fad215e37449c66fea1999063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Agreements</topic><topic>Anemia</topic><topic>Automation</topic><topic>Biology and Life Sciences</topic><topic>Biosensors</topic><topic>Bleeding</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood levels</topic><topic>Blood tests</topic><topic>Correlation</topic><topic>Dengue</topic><topic>Dengue fever</topic><topic>Dengue hemorrhagic fever</topic><topic>Diagnosis</topic><topic>Evaluation</topic><topic>Fever</topic><topic>Hematocrit</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Human diseases</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Measurement</topic><topic>Medicine and Health Sciences</topic><topic>Monitoring</topic><topic>Patients</topic><topic>Physicians</topic><topic>Plasma</topic><topic>Sensitivity</topic><topic>Software</topic><topic>Specificity</topic><topic>Telemedicine</topic><topic>Testing</topic><topic>Tropical diseases</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wisanuvej, Kantasit</creatorcontrib><creatorcontrib>Boonyawat, Kochawan</creatorcontrib><creatorcontrib>Savetamornkul, Chutchaiwat</creatorcontrib><creatorcontrib>Virapongsiri, Sirapong</creatorcontrib><creatorcontrib>Krongvorakul, Jatupon</creatorcontrib><creatorcontrib>Sungkanuparph, 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Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wisanuvej, Kantasit</au><au>Boonyawat, Kochawan</au><au>Savetamornkul, Chutchaiwat</au><au>Virapongsiri, Sirapong</au><au>Krongvorakul, Jatupon</au><au>Sungkanuparph, Somnuek</au><au>Phuphuakrat, Angsana</au><au>Diemert, David Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue</atitle><jtitle>PLoS neglected tropical diseases</jtitle><date>2021-08-01</date><risdate>2021</risdate><volume>15</volume><issue>8</issue><spage>e0009692</spage><epage>e0009692</epage><pages>e0009692-e0009692</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb [greater than or equal to]20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively. Conclusions Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb testing can decrease the frequency of venipuncture. Further study in children is encouraged.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>34398882</pmid><doi>10.1371/journal.pntd.0009692</doi><orcidid>https://orcid.org/0000-0003-1709-8772</orcidid><orcidid>https://orcid.org/0000-0002-1055-2963</orcidid><orcidid>https://orcid.org/0000-0003-2474-1850</orcidid><orcidid>https://orcid.org/0000-0001-9996-6013</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Agreements Anemia Automation Biology and Life Sciences Biosensors Bleeding Blood Blood & organ donations Blood levels Blood tests Correlation Dengue Dengue fever Dengue hemorrhagic fever Diagnosis Evaluation Fever Hematocrit Hemoglobin Hospitals Human diseases Infections Laboratories Measurement Medicine and Health Sciences Monitoring Patients Physicians Plasma Sensitivity Software Specificity Telemedicine Testing Tropical diseases Vector-borne diseases |
| title | Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue |
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