Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury

Background Liver has an important role in the initiation and progression of multiple organ failure that occurs in sepsis. Many natural active substances can be used to reduce the liver injury caused by sepsis. For this aim, the effects of myricetin and apigenin on mice model of acute liver injury wa...

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Veröffentlicht in:	Molecular biology reports 2021-09, Vol.48 (9), p.6363-6373
Hauptverfasser:	Berköz, Mehmet, Ünal, Seda, Karayakar, Fahri, Yunusoğlu, Oruç, Özkan-Yılmaz, Ferbal, Özlüer-Hunt, Arzu, Aslan, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animal Anatomy Animal Biochemistry Animals Apigenin - administration & dosage Bilirubin Biomedical and Life Sciences Catalase Catalase - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control Cyclooxygenase-2 Cytokines - blood Disease Models, Animal Flavonoids Flavonoids - administration & dosage Glutathione - blood Hepatitis, Animal - prevention & control Histology IL-1β Inflammation Interleukin 6 JNK protein Life Sciences Lipopolysaccharides Lipopolysaccharides - administration & dosage Lipopolysaccharides - adverse effects Liver Liver Function Tests Male Mice Mice, Inbred BALB C Morphology mRNA NF-κB protein Nitric-oxide synthase Oral administration Original Article Oxidative stress Oxidative Stress - drug effects Phosphorylation Pre-Exposure Prophylaxis - methods Prostaglandin E2 Protective Agents - administration & dosage Sepsis Serum Albumin - analysis Superoxide dismutase Superoxide Dismutase - blood Treatment Outcome Tumor necrosis factor-α
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