Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa
The global incidence of ulcerative colitis (UC) continues to increase while it's clinical cure rate remains low. Intestinal mucosal ulcers have segmental distribution and variable severity. Intestinal bacteria are closely related to intestinal immunity and metabolism; however, the relationship...
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| Veröffentlicht in: | Bioengineered 2021-01, Vol.12 (1), p.5195-5209 |
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| creator | Li, Dongyue Yang, Youlin Yin, Xunhai Liu, Yang Xu, Hongyu Ni, Yu Hang, Ping Niu, Sijia Zhang, Huichao Ding, Wenbo Kuang, Hongyu |
| description | The global incidence of ulcerative colitis (UC) continues to increase while it's clinical cure rate remains low. Intestinal mucosal ulcers have segmental distribution and variable severity. Intestinal bacteria are closely related to intestinal immunity and metabolism; however, the relationship between intestinal microbiome profile and the occurrence of UC, as well as the contribution of glucose metabolism, are not well understood. This was investigated in the present study using mucosal biopsies from patients with UC and healthy control subjects. We performed high throughput 16S rRNA gene sequencing to estimate microbiota composition and abundance as well as their association with clinical indices such as lesion severity. The results showed that the diversity and abundance of intestinal microbiota were significantly lower in patients with UC than in healthy subjects; however, these were unrelated to ulcer severity. Serum glucagon-like peptide 2 (GLP-2) level was associated with reduced microbiota diversity and abundance in UC. These results indicate that colonization by specific microbiota is not the main determinant of pathologic status in UC. Additionally, therapeutic strategies that increase GLP-2 levels in intestinal mucosa may be effective in the treatment of UC. |
| doi_str_mv | 10.1080/21655979.2021.1958600 |
| format | Article |
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Intestinal mucosal ulcers have segmental distribution and variable severity. Intestinal bacteria are closely related to intestinal immunity and metabolism; however, the relationship between intestinal microbiome profile and the occurrence of UC, as well as the contribution of glucose metabolism, are not well understood. This was investigated in the present study using mucosal biopsies from patients with UC and healthy control subjects. We performed high throughput 16S rRNA gene sequencing to estimate microbiota composition and abundance as well as their association with clinical indices such as lesion severity. The results showed that the diversity and abundance of intestinal microbiota were significantly lower in patients with UC than in healthy subjects; however, these were unrelated to ulcer severity. Serum glucagon-like peptide 2 (GLP-2) level was associated with reduced microbiota diversity and abundance in UC. These results indicate that colonization by specific microbiota is not the main determinant of pathologic status in UC. Additionally, therapeutic strategies that increase GLP-2 levels in intestinal mucosa may be effective in the treatment of UC.</description><identifier>ISSN: 2165-5979</identifier><identifier>EISSN: 2165-5987</identifier><identifier>DOI: 10.1080/21655979.2021.1958600</identifier><identifier>PMID: 34402720</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Adult ; Aged ; Colitis, Ulcerative - metabolism ; Colitis, Ulcerative - microbiology ; Colitis, Ulcerative - pathology ; Female ; Gastrointestinal Microbiome - physiology ; Glucagon-like peptide 2 ; Glucagon-Like Peptide 2 - analysis ; Glucagon-Like Peptide 2 - genetics ; Glucagon-Like Peptide 2 - metabolism ; Glucose - metabolism ; glucose metabolism analysis ; high-throughput 16S RNA sequencing ; High-Throughput Nucleotide Sequencing ; Humans ; intestinal microbiota ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - microbiology ; Intestinal Mucosa - pathology ; Male ; Middle Aged ; Research Paper ; ulcerative colitis</subject><ispartof>Bioengineered, 2021-01, Vol.12 (1), p.5195-5209</ispartof><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021</rights><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-6ff125dbbe2a50564115c157b314a273cda14c85378e4a754dfa9a0a4b3069b33</citedby><cites>FETCH-LOGICAL-c468t-6ff125dbbe2a50564115c157b314a273cda14c85378e4a754dfa9a0a4b3069b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806733/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806733/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34402720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Dongyue</creatorcontrib><creatorcontrib>Yang, Youlin</creatorcontrib><creatorcontrib>Yin, Xunhai</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Xu, Hongyu</creatorcontrib><creatorcontrib>Ni, Yu</creatorcontrib><creatorcontrib>Hang, Ping</creatorcontrib><creatorcontrib>Niu, Sijia</creatorcontrib><creatorcontrib>Zhang, Huichao</creatorcontrib><creatorcontrib>Ding, Wenbo</creatorcontrib><creatorcontrib>Kuang, Hongyu</creatorcontrib><title>Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa</title><title>Bioengineered</title><addtitle>Bioengineered</addtitle><description>The global incidence of ulcerative colitis (UC) continues to increase while it's clinical cure rate remains low. Intestinal mucosal ulcers have segmental distribution and variable severity. Intestinal bacteria are closely related to intestinal immunity and metabolism; however, the relationship between intestinal microbiome profile and the occurrence of UC, as well as the contribution of glucose metabolism, are not well understood. This was investigated in the present study using mucosal biopsies from patients with UC and healthy control subjects. We performed high throughput 16S rRNA gene sequencing to estimate microbiota composition and abundance as well as their association with clinical indices such as lesion severity. The results showed that the diversity and abundance of intestinal microbiota were significantly lower in patients with UC than in healthy subjects; however, these were unrelated to ulcer severity. Serum glucagon-like peptide 2 (GLP-2) level was associated with reduced microbiota diversity and abundance in UC. These results indicate that colonization by specific microbiota is not the main determinant of pathologic status in UC. Additionally, therapeutic strategies that increase GLP-2 levels in intestinal mucosa may be effective in the treatment of UC.</description><subject>Adult</subject><subject>Aged</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Colitis, Ulcerative - microbiology</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Glucagon-like peptide 2</subject><subject>Glucagon-Like Peptide 2 - analysis</subject><subject>Glucagon-Like Peptide 2 - genetics</subject><subject>Glucagon-Like Peptide 2 - metabolism</subject><subject>Glucose - metabolism</subject><subject>glucose metabolism analysis</subject><subject>high-throughput 16S RNA sequencing</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>intestinal microbiota</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Research Paper</subject><subject>ulcerative colitis</subject><issn>2165-5979</issn><issn>2165-5987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcuO0zAUhiMEYkbDPALIy2GR4kscJxsEGkFBqgQLWFsnttMaHLvYTlF5Hh6UWO1UsGFl6_yXY-urqucErwju8CtKWs570a8opmRFet61GD-qrsu85n0nHl_uor-qblP6hjEmmDVcdE-rK9Y0mAqKr6vfazcr2AZfO_vdoL3ZZ6sNultvPr9ENUV22sdwMBqp4IK3v6zfogFUNtECAq9RNHpWi57MYZnlIwojmp0yEbI9mBKz2SY0HJHxO_CqFOSdQXpRYyqB0gLD7PWimhK3PpuUrQeHplmFBM-qJyO4ZG7P50319f27L_cf6s2n9cf7t5taNW2X63YcCeV6GAwFjnnbEMIV4WJgpAEqmNJAGtVxJjrTgOCNHqEHDM3AcNsPjN1Ur0-9-3mYjFbG5whO7qOdIB5lACv_VbzdyW04yK7DrWCl4O5cEMOPefmEnGxSxjnwJsxJUt5SyhgXxcpPVhVDStGMlzUEywJZPkCWBbI8Q15yL_5-4yX1gHQxvDkZrB9DnOBniE7LDEcX4hgLgSTZ_3f8AWpougs</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Li, Dongyue</creator><creator>Yang, Youlin</creator><creator>Yin, Xunhai</creator><creator>Liu, Yang</creator><creator>Xu, Hongyu</creator><creator>Ni, Yu</creator><creator>Hang, Ping</creator><creator>Niu, Sijia</creator><creator>Zhang, Huichao</creator><creator>Ding, Wenbo</creator><creator>Kuang, Hongyu</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa</title><author>Li, Dongyue ; Yang, Youlin ; Yin, Xunhai ; Liu, Yang ; Xu, Hongyu ; Ni, Yu ; Hang, Ping ; Niu, Sijia ; Zhang, Huichao ; Ding, Wenbo ; Kuang, Hongyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-6ff125dbbe2a50564115c157b314a273cda14c85378e4a754dfa9a0a4b3069b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Colitis, Ulcerative - metabolism</topic><topic>Colitis, Ulcerative - microbiology</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Female</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Glucagon-like peptide 2</topic><topic>Glucagon-Like Peptide 2 - analysis</topic><topic>Glucagon-Like Peptide 2 - genetics</topic><topic>Glucagon-Like Peptide 2 - metabolism</topic><topic>Glucose - metabolism</topic><topic>glucose metabolism analysis</topic><topic>high-throughput 16S RNA sequencing</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Humans</topic><topic>intestinal microbiota</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Research Paper</topic><topic>ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Dongyue</creatorcontrib><creatorcontrib>Yang, Youlin</creatorcontrib><creatorcontrib>Yin, Xunhai</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Xu, Hongyu</creatorcontrib><creatorcontrib>Ni, Yu</creatorcontrib><creatorcontrib>Hang, Ping</creatorcontrib><creatorcontrib>Niu, Sijia</creatorcontrib><creatorcontrib>Zhang, Huichao</creatorcontrib><creatorcontrib>Ding, Wenbo</creatorcontrib><creatorcontrib>Kuang, Hongyu</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioengineered</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Dongyue</au><au>Yang, Youlin</au><au>Yin, Xunhai</au><au>Liu, Yang</au><au>Xu, Hongyu</au><au>Ni, Yu</au><au>Hang, Ping</au><au>Niu, Sijia</au><au>Zhang, Huichao</au><au>Ding, Wenbo</au><au>Kuang, Hongyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa</atitle><jtitle>Bioengineered</jtitle><addtitle>Bioengineered</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>12</volume><issue>1</issue><spage>5195</spage><epage>5209</epage><pages>5195-5209</pages><issn>2165-5979</issn><eissn>2165-5987</eissn><abstract>The global incidence of ulcerative colitis (UC) continues to increase while it's clinical cure rate remains low. Intestinal mucosal ulcers have segmental distribution and variable severity. Intestinal bacteria are closely related to intestinal immunity and metabolism; however, the relationship between intestinal microbiome profile and the occurrence of UC, as well as the contribution of glucose metabolism, are not well understood. This was investigated in the present study using mucosal biopsies from patients with UC and healthy control subjects. We performed high throughput 16S rRNA gene sequencing to estimate microbiota composition and abundance as well as their association with clinical indices such as lesion severity. The results showed that the diversity and abundance of intestinal microbiota were significantly lower in patients with UC than in healthy subjects; however, these were unrelated to ulcer severity. Serum glucagon-like peptide 2 (GLP-2) level was associated with reduced microbiota diversity and abundance in UC. These results indicate that colonization by specific microbiota is not the main determinant of pathologic status in UC. Additionally, therapeutic strategies that increase GLP-2 levels in intestinal mucosa may be effective in the treatment of UC.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>34402720</pmid><doi>10.1080/21655979.2021.1958600</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Colitis, Ulcerative - metabolism Colitis, Ulcerative - microbiology Colitis, Ulcerative - pathology Female Gastrointestinal Microbiome - physiology Glucagon-like peptide 2 Glucagon-Like Peptide 2 - analysis Glucagon-Like Peptide 2 - genetics Glucagon-Like Peptide 2 - metabolism Glucose - metabolism glucose metabolism analysis high-throughput 16S RNA sequencing High-Throughput Nucleotide Sequencing Humans intestinal microbiota Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Male Middle Aged Research Paper ulcerative colitis |
| title | Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa |
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