Monitoring the M-protein of multiple myeloma patients treated with a combination of monoclonal antibodies: the laboratory solution to eliminate interference

The therapeutic monoclonal antibody (t-mAb) daratumumab, used to treat multiple myeloma (MM) patients, interferes with routine, electrophoretic based M-protein diagnostics. Electrophoretic response assessment becomes increasingly difficult when multiple t-mAbs are combined for use in a single patien...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2021-11, Vol.59 (12), p.1963-1971
Hauptverfasser:	Noori, Somayya, Verkleij, Christie P. M., Zajec, Marina, Langerhorst, Pieter, Bosman, Patricia W. C., de Rijke, Yolanda B., Zweegman, Sonja, VanDuijn, Martijn, Luider, Theo, van de Donk, Niels W. C. J., Jacobs, Joannes F. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Assaying daratumumab Electrophoresis Humans hydrashift Immunoelectrophoresis immunofixation electrophoresis Immunoglobulin G Immunotherapy Interference Laboratories M-protein Mass Spectrometry Mass spectroscopy Minimal residual disease Monitoring Monoclonal antibodies monoclonal antibody Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - drug therapy nivolumab Peptides Proteins serum protein electrophoresis Targeted cancer therapy Telemedicine therapeutic drug monitoring
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