The ameliorative effect of N‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats

Penconazole (PEN) is a widely used systemic fungicide to treat various fungal diseases in plants but it leaves residues in crops and food products causing serious environmental and health problems. N‐acetylcysteine (NAC) is a precursor of the antioxidant glutathione in the body and exerts prominent...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2021-10, Vol.35 (10), p.e22884-n/a
Hauptverfasser:	Morgan, Ashraf M., Hassanen, Eman I., Ogaly, Hanan A., Al Dulmani, Sharah A., Al‐Zahrani, Fatimah A. M., Galal, Mona K., Kamel, Shaimaa, Rashad, Maha M., Ibrahim, Marwa A., Hussien, Ahmed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - administration & dosage Animals Anti-Inflammatory Agents - administration & dosage Antioxidants Antioxidants - administration & dosage Apoptosis Apoptosis - drug effects BAX protein bcl-2-Associated X Protein - metabolism Behavior, Animal - drug effects Body weight Brain Brain - metabolism Brain - pathology Caspase 3 - metabolism Caspase-3 Caspase-9 Cerebellum Cerebrum Chemical compounds Crop residues Disorders Distilled water Elevated Plus Maze Test Fungal diseases Fungicides Genes Glutathione Health problems histopathology Inflammation Male Males Malondialdehyde Malondialdehyde - metabolism mRNA Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - psychology Neuroinflammatory Diseases - chemically induced Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - metabolism Neuroinflammatory Diseases - psychology Neuroprotection Neuroprotective Agents - administration & dosage Neurotoxicity Nitric oxide N‐acetylcysteine Oxidative stress Oxidative Stress - drug effects Penconazole Pharmacology Plant diseases Rats Rats, Sprague-Dawley Rodents Signal Transduction - drug effects Toxicity Treatment Outcome Triazoles - adverse effects
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