Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins such as amyloid‐β peptide, glucagon, islet amyloid polypeptide (IAPP), and insulin‐like growth factors, which have div...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pathology 2021-12, Vol.255 (4), p.346-361
Hauptverfasser:	Sousa, Luís, Guarda, Mariana, Meneses, Maria João, Macedo, M Paula, Vicente Miranda, Hugo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amylin Amyloidogenesis amyloid‐β Animals Beta cells Diabetes mellitus (non-insulin dependent) Enzymes Glucagon Growth factors Heat shock proteins Humans Insulin insulin‐degrading enzyme Insulysin - metabolism Metabolic Diseases - enzymology Movement disorders Neurodegenerative diseases Neurodegenerative Diseases - enzymology neurodegenerative disorders Parkinson's disease Physiology Proteasomes Protein interaction Proteolysis Synuclein Therapeutic targets therapeutics type 2 diabetes mellitus Ubiquitin α‐synuclein β-Amyloid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!