The influence of glycosaminoglycan proteoglycan side chains on tensile force transmission and the nanostructural properties of Achilles tendons

This study investigates the nanostructural mechanisms that lie behind load transmission in tendons and the role of glycosaminoglycans (GAGs) in the transmission of force in the tendon extracellular matrix. The GAGs in white New Zealand rabbit Achilles tendons were enzymatically depleted, and the ten...

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Veröffentlicht in:	Microscopy research and technique 2022-01, Vol.85 (1), p.233-243
Hauptverfasser:	Al Makhzoomi, Anas K., Kirk, Thomas B., Dye, Danielle E., Allison, Garry T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Achilles Tendon Animals Atomic force microscopes Atomic force microscopy Biomechanical Phenomena Cyclic loads Damage accumulation Depletion differences in within‐fibril and between‐fibril‐bundle D‐periodicities D‐periodicity Elongation Extracellular matrix force transmission in tendons Glycosaminoglycans Mechanical properties Periodicity proteoglycan matrix Proteoglycans Rabbits Statistical analysis Strain Structure-function relationships tendon structure–function relationships Tendons
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