Total mouth photodynamic therapy mediated by red LED and porphyrin in individuals with AIDS

Due to the immune changes resulting from HIV/AIDS infection, systemic and local infections throughout the body are common. The use of high activity antiretroviral therapy has been widely used during treatment, which, added to the use of antibiotics, antifungals, and the patients’ own immunocompromis...

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Veröffentlicht in:Lasers in medical science 2022-03, Vol.37 (2), p.1227-1234
Hauptverfasser: da Silva, Francine Cristina, Rosa, Luciano Pereira, de Jesus, Iasmym Mendes, de Oliveira Santos, Gabriel Pinto, Inada, Natália Mayumi, Blanco, Kate Cristina, Araújo, Thalita Santos Dantas, Bagnato, Vanderlei Salvador
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container_issue 2
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container_title Lasers in medical science
container_volume 37
creator da Silva, Francine Cristina
Rosa, Luciano Pereira
de Jesus, Iasmym Mendes
de Oliveira Santos, Gabriel Pinto
Inada, Natália Mayumi
Blanco, Kate Cristina
Araújo, Thalita Santos Dantas
Bagnato, Vanderlei Salvador
description Due to the immune changes resulting from HIV/AIDS infection, systemic and local infections throughout the body are common. The use of high activity antiretroviral therapy has been widely used during treatment, which, added to the use of antibiotics, antifungals, and the patients’ own immunocompromised state, cause important changes in the oral microbiota. The emergence of pathological microorganisms and with high resistance to drug therapies are frequent and cause serious damage to the oral health of these patients. In this sense, antimicrobial photodynamic therapy (aPDT) appears as a promising alternative in the control of these oral infections. The aim of the study was to test the effectiveness of a therapeutic protocol for total oral aPDT mediated by a 660-nm red LED (light-emitting diode) associated with porphyrin in individuals with AIDS. Patients were selected by exclusion criteria and randomly distributed into groups to test the effectiveness of antimicrobial aPDT with 50 µg/ml porphyrin associated with the red LED. Before and after the treatments, saliva samples were collected and processed in duplicate in selective culture media. Colonies were counted and the results obtained in Log10 CFU/ml and tested statistically. It was concluded that aPDT was effective in reducing oral enterobacteria, in addition to reducing Streptococcus spp. and general count of microorganisms, when considering the numbers of TCD4 and TCD8 lymphocytes.
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subjects Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - drug therapy
AIDS
Antibiotics
Antiinfectives and antibacterials
Antiretroviral agents
Antiretroviral therapy
Culture media
Dentistry
High resistance
HIV
Human immunodeficiency virus
Humans
Infections
Lasers
Light emitting diodes
Lymphocytes
Medicine
Medicine & Public Health
Microbiota
Microorganisms
Mouth
Optical Devices
Optics
Original Article
Patients
Photochemotherapy - methods
Photodynamic therapy
Photonics
Photosensitizing Agents - therapeutic use
Porphyrins
Porphyrins - therapeutic use
Quantum Optics
Saliva
Selective media
Statistical methods
Streptococcus infections
title Total mouth photodynamic therapy mediated by red LED and porphyrin in individuals with AIDS
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