Towards Virtual Bioequivalence Studies for Oral Dosage Forms Containing Poorly Water-Soluble Drugs: A Physiologically Based Biopharmaceutics Modeling (PBBM) Approach

The objective of the present study was to develop a physiologically based biopharmaceutics (PBBM) approach to predict the bioequivalence of dosage forms containing poorly soluble drugs. Aripiprazole and enzalutamide were used as model drugs. Variations in the gastrointestinal (GI) physiological para...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2022-01, Vol.111 (1), p.135-145
Hauptverfasser:	Kambayashi, Atsushi, Dressman, Jennifer B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Bioequivalence Biopharmaceutics Biorelevant dissolution Computer Simulation Humans Intestinal Absorption - physiology Modeling and simulation Models, Biological PBBM PBPK Solubility Therapeutic Equivalency Water
Online-Zugang:	Volltext
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