Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: A promising approach in cancer treatment

•The development of new and optimized anticancer therapies is an urgent requirement.•Serine/threonine-protein phosphatase 1 (PP1) has been recognized as a potential drug target in cancer.•Several PP1 complexes have been characterized in cancer models.•The disruption or stabilization of PP1 complexes...

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Veröffentlicht in:	Drug discovery today 2021-11, Vol.26 (11), p.2680-2698
Hauptverfasser:	Matos, Bárbara, Howl, John, Jerónimo, Carmen, Fardilha, Margarida
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer treatment Humans Multiprotein Complexes - metabolism Neoplasms - drug therapy Neoplasms - metabolism Peptides PP1 complexes Protein Phosphatase 1 - metabolism Small molecules
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