Simultaneous determination of triazine herbicides and their metabolites in shellfish by HPLC-MS/MS combined with Q/E-Orbitrap HRMS
Triazine herbicides are used extensively in agriculture and aquaculture worldwide because of their broad effectiveness in weed control. However, after they are discharged into the sea, they seriously contaminate aquatic ecosystems and threaten aquatic organisms, especially shellfish. Currently, ther...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2021-10, Vol.413 (25), p.6239-6252 |
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| creator | Sun, Xiaojie Gao, Jinfang Xing, Jun Xing, Lihong Guo, Mengmeng Peng, Jixing Li, Zhaoxin Tan, Zhijun |
| description | Triazine herbicides are used extensively in agriculture and aquaculture worldwide because of their broad effectiveness in weed control. However, after they are discharged into the sea, they seriously contaminate aquatic ecosystems and threaten aquatic organisms, especially shellfish. Currently, there are no established methods for the detection and confirmation of triazine herbicides and their metabolites in biological matrixes. Hence, the food safety of aquatic products cannot be accurately evaluated, which creates a technical barrier against international aquatic product trade. In this study, for the first time, a method was developed for the analysis and confirmation of seven triazine herbicides and 13 metabolites in shellfish, based on alkaline acetonitrile extraction and neutral Al
2
O
3
cartridge purification coupled with internal standard calibration. Specifically, quantitative and qualitative analysis was conducted using high-performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-MS/MS), and accurate identification was carried out by quadrupole orbitrap high-resolution mass spectrometry (Q/E Orbitrap HRMS). The results showed that target analytes demonstrated good linearity within the corresponding range (
R
2
> 0.995). The limit of detection and limit of quantitation of the proposed method were 0.1 and 0.3 μg/kg, respectively. The average recoveries of analytes were between 70.0% and 120% when spiked at three levels with blank oyster (
Crassostrea gigas
) as the matrix, and the relative standard deviations (RSDs) were all less than 12% (
n
=6). The proposed method was successfully applied for the detection of triazine herbicide residues in oyster samples during actual breeding, and the presence of DIP, HP, DEHA, and other metabolites in positive samples was confirmed by Q/E Orbitrap HRMS. This method exhibits high accuracy, high sensitivity, and good reproducibility. It has promising application prospects in the field of hazard analysis and the positive identification of aquatic products.
Graphical abstract |
| doi_str_mv | 10.1007/s00216-021-03579-y |
| format | Article |
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2
O
3
cartridge purification coupled with internal standard calibration. Specifically, quantitative and qualitative analysis was conducted using high-performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-MS/MS), and accurate identification was carried out by quadrupole orbitrap high-resolution mass spectrometry (Q/E Orbitrap HRMS). The results showed that target analytes demonstrated good linearity within the corresponding range (
R
2
> 0.995). The limit of detection and limit of quantitation of the proposed method were 0.1 and 0.3 μg/kg, respectively. The average recoveries of analytes were between 70.0% and 120% when spiked at three levels with blank oyster (
Crassostrea gigas
) as the matrix, and the relative standard deviations (RSDs) were all less than 12% (
n
=6). The proposed method was successfully applied for the detection of triazine herbicide residues in oyster samples during actual breeding, and the presence of DIP, HP, DEHA, and other metabolites in positive samples was confirmed by Q/E Orbitrap HRMS. This method exhibits high accuracy, high sensitivity, and good reproducibility. It has promising application prospects in the field of hazard analysis and the positive identification of aquatic products.
Graphical abstract</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-021-03579-y</identifier><identifier>PMID: 34389879</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetonitrile ; Agrochemicals ; Aluminum oxide ; Analytical Chemistry ; Animals ; Aquaculture ; Aquatic ecosystems ; Aquatic organisms ; Biochemistry ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromatography, High Pressure Liquid - methods ; Food Contamination - analysis ; Food safety ; Food Science ; Hazard assessment ; Herbicide residues ; Herbicides ; Herbicides - chemistry ; Herbicides - metabolism ; High performance liquid chromatography ; Identification and classification ; Laboratory Medicine ; Limit of Detection ; Liquid chromatography ; Mass spectrometry ; Mass Spectrometry - methods ; Mass spectroscopy ; Metabolites ; Methods ; Monitoring/Environmental Analysis ; Ostreidae - chemistry ; Ostreidae - metabolism ; Oysters ; Pesticide Residues - chemistry ; Product safety ; Quadrupoles ; Qualitative analysis ; Quantitation ; Reproducibility of Results ; Research Paper ; Scientific imaging ; Shellfish ; Shellfish - analysis ; Spectroscopy ; Triazine ; Triazines - chemistry ; Weed control</subject><ispartof>Analytical and bioanalytical chemistry, 2021-10, Vol.413 (25), p.6239-6252</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-fb885f750f9caf8eb13470b5cba0c8d942ad574dfbc2a134f6f0f8fa596b4bd13</citedby><cites>FETCH-LOGICAL-c414t-fb885f750f9caf8eb13470b5cba0c8d942ad574dfbc2a134f6f0f8fa596b4bd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-021-03579-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-021-03579-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34389879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Xiaojie</creatorcontrib><creatorcontrib>Gao, Jinfang</creatorcontrib><creatorcontrib>Xing, Jun</creatorcontrib><creatorcontrib>Xing, Lihong</creatorcontrib><creatorcontrib>Guo, Mengmeng</creatorcontrib><creatorcontrib>Peng, Jixing</creatorcontrib><creatorcontrib>Li, Zhaoxin</creatorcontrib><creatorcontrib>Tan, Zhijun</creatorcontrib><title>Simultaneous determination of triazine herbicides and their metabolites in shellfish by HPLC-MS/MS combined with Q/E-Orbitrap HRMS</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Triazine herbicides are used extensively in agriculture and aquaculture worldwide because of their broad effectiveness in weed control. However, after they are discharged into the sea, they seriously contaminate aquatic ecosystems and threaten aquatic organisms, especially shellfish. Currently, there are no established methods for the detection and confirmation of triazine herbicides and their metabolites in biological matrixes. Hence, the food safety of aquatic products cannot be accurately evaluated, which creates a technical barrier against international aquatic product trade. In this study, for the first time, a method was developed for the analysis and confirmation of seven triazine herbicides and 13 metabolites in shellfish, based on alkaline acetonitrile extraction and neutral Al
2
O
3
cartridge purification coupled with internal standard calibration. Specifically, quantitative and qualitative analysis was conducted using high-performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-MS/MS), and accurate identification was carried out by quadrupole orbitrap high-resolution mass spectrometry (Q/E Orbitrap HRMS). The results showed that target analytes demonstrated good linearity within the corresponding range (
R
2
> 0.995). The limit of detection and limit of quantitation of the proposed method were 0.1 and 0.3 μg/kg, respectively. The average recoveries of analytes were between 70.0% and 120% when spiked at three levels with blank oyster (
Crassostrea gigas
) as the matrix, and the relative standard deviations (RSDs) were all less than 12% (
n
=6). The proposed method was successfully applied for the detection of triazine herbicide residues in oyster samples during actual breeding, and the presence of DIP, HP, DEHA, and other metabolites in positive samples was confirmed by Q/E Orbitrap HRMS. This method exhibits high accuracy, high sensitivity, and good reproducibility. It has promising application prospects in the field of hazard analysis and the positive identification of aquatic products.
Graphical abstract</description><subject>Acetonitrile</subject><subject>Agrochemicals</subject><subject>Aluminum oxide</subject><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Aquaculture</subject><subject>Aquatic ecosystems</subject><subject>Aquatic organisms</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Food Contamination - analysis</subject><subject>Food safety</subject><subject>Food Science</subject><subject>Hazard assessment</subject><subject>Herbicide residues</subject><subject>Herbicides</subject><subject>Herbicides - chemistry</subject><subject>Herbicides - metabolism</subject><subject>High performance liquid chromatography</subject><subject>Identification and classification</subject><subject>Laboratory Medicine</subject><subject>Limit of Detection</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Mass spectroscopy</subject><subject>Metabolites</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Ostreidae - chemistry</subject><subject>Ostreidae - metabolism</subject><subject>Oysters</subject><subject>Pesticide Residues - chemistry</subject><subject>Product safety</subject><subject>Quadrupoles</subject><subject>Qualitative analysis</subject><subject>Quantitation</subject><subject>Reproducibility of Results</subject><subject>Research Paper</subject><subject>Scientific imaging</subject><subject>Shellfish</subject><subject>Shellfish - analysis</subject><subject>Spectroscopy</subject><subject>Triazine</subject><subject>Triazines - chemistry</subject><subject>Weed control</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhSMEoqXwB1ggS2zYpGMnfmVZjQqDNKMCA2vLz8ZV4gy2o2pY9pfXJaVILJCla-v6u0fn6lTVWwTPEYRslSBsEK1LqWFLWFcfn1WniCJeN5TA509v3JxUr1K6gRARjujL6qTFLe84606ru70f5yHLYKc5AWOzjaMPMvspgMmBHL385YMFvY3Ka29sAjIYkHvrIxhtlmoafC5dH0Dq7TA4n3qgjmDzZbuud_vVbg_0NKqiYcCtzz34urqsr4pYjvIANt92-9fVCyeHZN883mfVj4-X39ebenv16fP6YltrjHCuneKcOEag67R03CrUYgYV0UpCzU2HG2kIw8Yp3cjy56iDjjtJOqqwMqg9qz4suoc4_ZxtymL0SRfLy_KiIRRh3kFIC_r-H_RmmmMo7grFOMUcMVao84W6loMVPrip7KTLMXb0egrW-dK_oIxxQiB9kG2WAR2nlKJ14hD9KONRICgeIhVLpKIU8TtScSxD7x69zGq05mnkT4YFaBcgla9wbeNfs_-RvQcHza19</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Sun, Xiaojie</creator><creator>Gao, Jinfang</creator><creator>Xing, Jun</creator><creator>Xing, Lihong</creator><creator>Guo, Mengmeng</creator><creator>Peng, Jixing</creator><creator>Li, Zhaoxin</creator><creator>Tan, Zhijun</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20211001</creationdate><title>Simultaneous determination of triazine herbicides and their metabolites in shellfish by HPLC-MS/MS combined with Q/E-Orbitrap HRMS</title><author>Sun, Xiaojie ; Gao, Jinfang ; Xing, Jun ; Xing, Lihong ; Guo, Mengmeng ; Peng, Jixing ; Li, Zhaoxin ; Tan, Zhijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-fb885f750f9caf8eb13470b5cba0c8d942ad574dfbc2a134f6f0f8fa596b4bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetonitrile</topic><topic>Agrochemicals</topic><topic>Aluminum oxide</topic><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Aquaculture</topic><topic>Aquatic ecosystems</topic><topic>Aquatic organisms</topic><topic>Biochemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Food Contamination - analysis</topic><topic>Food safety</topic><topic>Food Science</topic><topic>Hazard assessment</topic><topic>Herbicide residues</topic><topic>Herbicides</topic><topic>Herbicides - chemistry</topic><topic>Herbicides - metabolism</topic><topic>High performance liquid chromatography</topic><topic>Identification and classification</topic><topic>Laboratory Medicine</topic><topic>Limit of Detection</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Mass spectroscopy</topic><topic>Metabolites</topic><topic>Methods</topic><topic>Monitoring/Environmental Analysis</topic><topic>Ostreidae - chemistry</topic><topic>Ostreidae - metabolism</topic><topic>Oysters</topic><topic>Pesticide Residues - chemistry</topic><topic>Product safety</topic><topic>Quadrupoles</topic><topic>Qualitative analysis</topic><topic>Quantitation</topic><topic>Reproducibility of Results</topic><topic>Research Paper</topic><topic>Scientific imaging</topic><topic>Shellfish</topic><topic>Shellfish - analysis</topic><topic>Spectroscopy</topic><topic>Triazine</topic><topic>Triazines - chemistry</topic><topic>Weed control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Xiaojie</creatorcontrib><creatorcontrib>Gao, Jinfang</creatorcontrib><creatorcontrib>Xing, Jun</creatorcontrib><creatorcontrib>Xing, Lihong</creatorcontrib><creatorcontrib>Guo, Mengmeng</creatorcontrib><creatorcontrib>Peng, Jixing</creatorcontrib><creatorcontrib>Li, Zhaoxin</creatorcontrib><creatorcontrib>Tan, Zhijun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Xiaojie</au><au>Gao, Jinfang</au><au>Xing, Jun</au><au>Xing, Lihong</au><au>Guo, Mengmeng</au><au>Peng, Jixing</au><au>Li, Zhaoxin</au><au>Tan, Zhijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of triazine herbicides and their metabolites in shellfish by HPLC-MS/MS combined with Q/E-Orbitrap HRMS</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>413</volume><issue>25</issue><spage>6239</spage><epage>6252</epage><pages>6239-6252</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Triazine herbicides are used extensively in agriculture and aquaculture worldwide because of their broad effectiveness in weed control. However, after they are discharged into the sea, they seriously contaminate aquatic ecosystems and threaten aquatic organisms, especially shellfish. Currently, there are no established methods for the detection and confirmation of triazine herbicides and their metabolites in biological matrixes. Hence, the food safety of aquatic products cannot be accurately evaluated, which creates a technical barrier against international aquatic product trade. In this study, for the first time, a method was developed for the analysis and confirmation of seven triazine herbicides and 13 metabolites in shellfish, based on alkaline acetonitrile extraction and neutral Al
2
O
3
cartridge purification coupled with internal standard calibration. Specifically, quantitative and qualitative analysis was conducted using high-performance liquid chromatography-triple quadrupole mass spectrometry (HPLC-MS/MS), and accurate identification was carried out by quadrupole orbitrap high-resolution mass spectrometry (Q/E Orbitrap HRMS). The results showed that target analytes demonstrated good linearity within the corresponding range (
R
2
> 0.995). The limit of detection and limit of quantitation of the proposed method were 0.1 and 0.3 μg/kg, respectively. The average recoveries of analytes were between 70.0% and 120% when spiked at three levels with blank oyster (
Crassostrea gigas
) as the matrix, and the relative standard deviations (RSDs) were all less than 12% (
n
=6). The proposed method was successfully applied for the detection of triazine herbicide residues in oyster samples during actual breeding, and the presence of DIP, HP, DEHA, and other metabolites in positive samples was confirmed by Q/E Orbitrap HRMS. This method exhibits high accuracy, high sensitivity, and good reproducibility. It has promising application prospects in the field of hazard analysis and the positive identification of aquatic products.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34389879</pmid><doi>10.1007/s00216-021-03579-y</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-2642 |
| ispartof | Analytical and bioanalytical chemistry, 2021-10, Vol.413 (25), p.6239-6252 |
| issn | 1618-2642 1618-2650 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2561489006 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetonitrile Agrochemicals Aluminum oxide Analytical Chemistry Animals Aquaculture Aquatic ecosystems Aquatic organisms Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography, High Pressure Liquid - methods Food Contamination - analysis Food safety Food Science Hazard assessment Herbicide residues Herbicides Herbicides - chemistry Herbicides - metabolism High performance liquid chromatography Identification and classification Laboratory Medicine Limit of Detection Liquid chromatography Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Metabolites Methods Monitoring/Environmental Analysis Ostreidae - chemistry Ostreidae - metabolism Oysters Pesticide Residues - chemistry Product safety Quadrupoles Qualitative analysis Quantitation Reproducibility of Results Research Paper Scientific imaging Shellfish Shellfish - analysis Spectroscopy Triazine Triazines - chemistry Weed control |
| title | Simultaneous determination of triazine herbicides and their metabolites in shellfish by HPLC-MS/MS combined with Q/E-Orbitrap HRMS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T13%3A18%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Simultaneous%20determination%20of%20triazine%20herbicides%20and%20their%20metabolites%20in%20shellfish%20by%20HPLC-MS/MS%20combined%20with%20Q/E-Orbitrap%20HRMS&rft.jtitle=Analytical%20and%20bioanalytical%20chemistry&rft.au=Sun,%20Xiaojie&rft.date=2021-10-01&rft.volume=413&rft.issue=25&rft.spage=6239&rft.epage=6252&rft.pages=6239-6252&rft.issn=1618-2642&rft.eissn=1618-2650&rft_id=info:doi/10.1007/s00216-021-03579-y&rft_dat=%3Cgale_proqu%3EA677855066%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2578648177&rft_id=info:pmid/34389879&rft_galeid=A677855066&rfr_iscdi=true |