Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface
Although brain structural studies have demonstrated the neural correlates of neuroticism, the outcomes are not easily identified because of the various possible brain regions involved, low statistical power (low number of subjects), and brain structural measures available, such as mean diffusivity (...
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| Veröffentlicht in: | Journal of psychosomatic research 2021-10, Vol.149, p.110590-110590, Article 110590 |
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| creator | Nakagawa, Seishu Takeuchi, Hikaru Taki, Yasuyuki Nouchi, Rui Kotozaki, Yuka Shinada, Takamitsu Maruyama, Tsukasa Sekiguchid, Atsushi Iizuka, Kunio Yokoyama, Ryoichi Yamamoto, Yuki Hanawa, Sugiko Araki, Tsuyoshi Miyauchi, Carlos Makoto Magistro, Daniele Sakaki, Kohei Jeong, Hyeonjeong Kawashima, Ryuta |
| description | Although brain structural studies have demonstrated the neural correlates of neuroticism, the outcomes are not easily identified because of the various possible brain regions involved, low statistical power (low number of subjects), and brain structural measures available, such as mean diffusivity (MD), which are more suitable than standard regional measures of grey and white-matter volume (rGMV, rWMV) and fractional anisotropy (FA). We hypothesized that neuroticism neural correlates could be detected by MD and differentially identified using other measures. We aimed to visualize the neural correlates of neuroticism.
A voxel-by-voxel regression analysis was performed using the MD, rGMV, rWMV, or FA value as the dependent variable and with neuroticism scores based on the NEO-FFI and its confounding factors as independent variables in 1207 (693 men and 514 women; age, 20.7 ± 1.8, 18–27 years), non-clinical students in a cross-sectional study.
MD in the cortico- (orbitofrontal cortex, anterior cingulate cortex, and posterior insula) striatal- (caudate and putamen) thalamic loop regions, including the right posterior limb of the internal capsule, were positively associated with neuroticism using the threshold-free cluster enhancement method with a family-wise error-corrected threshold of P |
| doi_str_mv | 10.1016/j.jpsychores.2021.110590 |
| format | Article |
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A voxel-by-voxel regression analysis was performed using the MD, rGMV, rWMV, or FA value as the dependent variable and with neuroticism scores based on the NEO-FFI and its confounding factors as independent variables in 1207 (693 men and 514 women; age, 20.7 ± 1.8, 18–27 years), non-clinical students in a cross-sectional study.
MD in the cortico- (orbitofrontal cortex, anterior cingulate cortex, and posterior insula) striatal- (caudate and putamen) thalamic loop regions, including the right posterior limb of the internal capsule, were positively associated with neuroticism using the threshold-free cluster enhancement method with a family-wise error-corrected threshold of P < 0.0125 (0.05/4, Bonferroni correction for four types of MRI data [MD, rGMV, rWMV, and FA]) at the whole-brain level.
An increased MD has generally been associated with reduced neural tissues and possibly area function. Accordingly, this finding helps elucidate the mechanism of somatization in neuroticism because the regions related to neuroticism are considered neural correlates of somatoform disorders.
•Neuroticism is related to reduced neural tissue in the cortico-striatal-thalamic loop.•The orbitofrontal and anterior cingulate cortex, caudate and putamen are the regions.•The posterior insula and posterior limb of the internal capsule includes the regions.•The regions are considered neural correlates of somatoform disorders.•Mean diffusivity values represent a certain loss of components of the tissue system.</description><identifier>ISSN: 0022-3999</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/j.jpsychores.2021.110590</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Anisotropy ; Brain ; Confounding factors ; Cortex ; Cortex (cingulate) ; Cortico-striatal-thalamic loop ; Magnetic resonance imaging ; Mean diffusivity ; Mind and body ; Neostriatum ; Neurosis ; Neuroticism ; Posterior limb of the internal capsule ; Putamen ; Somatization ; Somatoform disorders ; Statistical power ; Substantia alba ; Thalamus</subject><ispartof>Journal of psychosomatic research, 2021-10, Vol.149, p.110590-110590, Article 110590</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright Elsevier Science Ltd. Oct 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c440t-9fa8ccd552177caaa05d2faba8b5138493fc6189bcca81470434d3f52937e31c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychores.2021.110590$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,30980,45976</link.rule.ids></links><search><creatorcontrib>Nakagawa, Seishu</creatorcontrib><creatorcontrib>Takeuchi, Hikaru</creatorcontrib><creatorcontrib>Taki, Yasuyuki</creatorcontrib><creatorcontrib>Nouchi, Rui</creatorcontrib><creatorcontrib>Kotozaki, Yuka</creatorcontrib><creatorcontrib>Shinada, Takamitsu</creatorcontrib><creatorcontrib>Maruyama, Tsukasa</creatorcontrib><creatorcontrib>Sekiguchid, Atsushi</creatorcontrib><creatorcontrib>Iizuka, Kunio</creatorcontrib><creatorcontrib>Yokoyama, Ryoichi</creatorcontrib><creatorcontrib>Yamamoto, Yuki</creatorcontrib><creatorcontrib>Hanawa, Sugiko</creatorcontrib><creatorcontrib>Araki, Tsuyoshi</creatorcontrib><creatorcontrib>Miyauchi, Carlos Makoto</creatorcontrib><creatorcontrib>Magistro, Daniele</creatorcontrib><creatorcontrib>Sakaki, Kohei</creatorcontrib><creatorcontrib>Jeong, Hyeonjeong</creatorcontrib><creatorcontrib>Kawashima, Ryuta</creatorcontrib><title>Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface</title><title>Journal of psychosomatic research</title><description>Although brain structural studies have demonstrated the neural correlates of neuroticism, the outcomes are not easily identified because of the various possible brain regions involved, low statistical power (low number of subjects), and brain structural measures available, such as mean diffusivity (MD), which are more suitable than standard regional measures of grey and white-matter volume (rGMV, rWMV) and fractional anisotropy (FA). We hypothesized that neuroticism neural correlates could be detected by MD and differentially identified using other measures. We aimed to visualize the neural correlates of neuroticism.
A voxel-by-voxel regression analysis was performed using the MD, rGMV, rWMV, or FA value as the dependent variable and with neuroticism scores based on the NEO-FFI and its confounding factors as independent variables in 1207 (693 men and 514 women; age, 20.7 ± 1.8, 18–27 years), non-clinical students in a cross-sectional study.
MD in the cortico- (orbitofrontal cortex, anterior cingulate cortex, and posterior insula) striatal- (caudate and putamen) thalamic loop regions, including the right posterior limb of the internal capsule, were positively associated with neuroticism using the threshold-free cluster enhancement method with a family-wise error-corrected threshold of P < 0.0125 (0.05/4, Bonferroni correction for four types of MRI data [MD, rGMV, rWMV, and FA]) at the whole-brain level.
An increased MD has generally been associated with reduced neural tissues and possibly area function. Accordingly, this finding helps elucidate the mechanism of somatization in neuroticism because the regions related to neuroticism are considered neural correlates of somatoform disorders.
•Neuroticism is related to reduced neural tissue in the cortico-striatal-thalamic loop.•The orbitofrontal and anterior cingulate cortex, caudate and putamen are the regions.•The posterior insula and posterior limb of the internal capsule includes the regions.•The regions are considered neural correlates of somatoform disorders.•Mean diffusivity values represent a certain loss of components of the tissue system.</description><subject>Anisotropy</subject><subject>Brain</subject><subject>Confounding factors</subject><subject>Cortex</subject><subject>Cortex (cingulate)</subject><subject>Cortico-striatal-thalamic loop</subject><subject>Magnetic resonance imaging</subject><subject>Mean diffusivity</subject><subject>Mind and body</subject><subject>Neostriatum</subject><subject>Neurosis</subject><subject>Neuroticism</subject><subject>Posterior limb of the internal capsule</subject><subject>Putamen</subject><subject>Somatization</subject><subject>Somatoform disorders</subject><subject>Statistical power</subject><subject>Substantia alba</subject><subject>Thalamus</subject><issn>0022-3999</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkE1r3DAQhkVIIJs0_0HQSy_e6sOypWO7NGkgkEtyrZgdj1kZ29pK2sL--3i7hUIuOQ0Mz_sy8zDGpVhLIZuvw3rY5yPuYqK8VkLJtZTCOHHBVtK2rpK6EZdsJYRSlXbOXbObnAchROOUWbFfm5hKwFjlkgIUGKuygxGmgHyMcc8hc-AzHRKMHGNKNEIhHvu_u7gkQ554mHnZEZ_C3FXb2B2XRaHUA9IndtXDmOnu37xlr_c_XjY_q6fnh8fNt6cK61qUyvVgETtjlGxbBABhOtXDFuzWSG1rp3tspHVbRLCybkWt6073Rjndkpaob9mXc-8-xd8HysVPISONI8wUD9kr08jaGmfFgn5-hw7xkObluoWyolVOyRNlzxSmmHOi3u9TmCAdvRT-JN4P_r94fxLvz-KX6PdzlJaH_wRKPmOgGakLibD4LoaPS94A-1SR9Q</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Nakagawa, Seishu</creator><creator>Takeuchi, Hikaru</creator><creator>Taki, Yasuyuki</creator><creator>Nouchi, Rui</creator><creator>Kotozaki, Yuka</creator><creator>Shinada, Takamitsu</creator><creator>Maruyama, Tsukasa</creator><creator>Sekiguchid, Atsushi</creator><creator>Iizuka, Kunio</creator><creator>Yokoyama, Ryoichi</creator><creator>Yamamoto, Yuki</creator><creator>Hanawa, Sugiko</creator><creator>Araki, Tsuyoshi</creator><creator>Miyauchi, Carlos Makoto</creator><creator>Magistro, Daniele</creator><creator>Sakaki, Kohei</creator><creator>Jeong, Hyeonjeong</creator><creator>Kawashima, Ryuta</creator><general>Elsevier Inc</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>202110</creationdate><title>Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface</title><author>Nakagawa, Seishu ; 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We hypothesized that neuroticism neural correlates could be detected by MD and differentially identified using other measures. We aimed to visualize the neural correlates of neuroticism.
A voxel-by-voxel regression analysis was performed using the MD, rGMV, rWMV, or FA value as the dependent variable and with neuroticism scores based on the NEO-FFI and its confounding factors as independent variables in 1207 (693 men and 514 women; age, 20.7 ± 1.8, 18–27 years), non-clinical students in a cross-sectional study.
MD in the cortico- (orbitofrontal cortex, anterior cingulate cortex, and posterior insula) striatal- (caudate and putamen) thalamic loop regions, including the right posterior limb of the internal capsule, were positively associated with neuroticism using the threshold-free cluster enhancement method with a family-wise error-corrected threshold of P < 0.0125 (0.05/4, Bonferroni correction for four types of MRI data [MD, rGMV, rWMV, and FA]) at the whole-brain level.
An increased MD has generally been associated with reduced neural tissues and possibly area function. Accordingly, this finding helps elucidate the mechanism of somatization in neuroticism because the regions related to neuroticism are considered neural correlates of somatoform disorders.
•Neuroticism is related to reduced neural tissue in the cortico-striatal-thalamic loop.•The orbitofrontal and anterior cingulate cortex, caudate and putamen are the regions.•The posterior insula and posterior limb of the internal capsule includes the regions.•The regions are considered neural correlates of somatoform disorders.•Mean diffusivity values represent a certain loss of components of the tissue system.</abstract><cop>London</cop><pub>Elsevier Inc</pub><doi>10.1016/j.jpsychores.2021.110590</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anisotropy Brain Confounding factors Cortex Cortex (cingulate) Cortico-striatal-thalamic loop Magnetic resonance imaging Mean diffusivity Mind and body Neostriatum Neurosis Neuroticism Posterior limb of the internal capsule Putamen Somatization Somatoform disorders Statistical power Substantia alba Thalamus |
| title | Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface |
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