What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case‐control from a sarcoma referral centre
Background and Objectives Nonpulmonary metastases (NPM) are rare, associated with a poorer prognosis, and maybe missed on conventional chest imaging for sarcoma surveillance. We determined (1) the proportion of NPM occurring in isolation or with synchronous or prior pulmonary metastases (PM), and (2...
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| Veröffentlicht in: | Journal of surgical oncology 2021-12, Vol.124 (8), p.1491-1498 |
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| container_title | Journal of surgical oncology |
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| creator | Hasan, Obada Nasir, Momin Jessar, Muneeba Hashimi, Mustafa An, Qiang Miller, Benjamin J. |
| description | Background and Objectives
Nonpulmonary metastases (NPM) are rare, associated with a poorer prognosis, and maybe missed on conventional chest imaging for sarcoma surveillance. We determined (1) the proportion of NPM occurring in isolation or with synchronous or prior pulmonary metastases (PM), and (2) if initial NPM would have been recognized with a standard surveillance protocol.
Methods
Investigators identified patients who developed initial NPM without prior evidence of or concurrent PM from an ongoing cohort of bone and soft tissue sarcoma (STS) patients. Logistic regression at univariate level was done.
Results
There were 138/630 (22%) patients with metastasis and 66 (10%) had NPM: 50 (8%) patients had PM presenting first, while 16 (3%) had initial NPM. Malignant peripheral nerve sheath tumor, angiosarcoma, rhabdomyosarcoma, synovial sarcoma, and myxoid liposarcoma were six times more likely to develop initial NPM than other subtypes of STS with odds ratio = 6 (95% confidence interval: 1.93–18.65, p value |
| doi_str_mv | 10.1002/jso.26645 |
| format | Article |
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Nonpulmonary metastases (NPM) are rare, associated with a poorer prognosis, and maybe missed on conventional chest imaging for sarcoma surveillance. We determined (1) the proportion of NPM occurring in isolation or with synchronous or prior pulmonary metastases (PM), and (2) if initial NPM would have been recognized with a standard surveillance protocol.
Methods
Investigators identified patients who developed initial NPM without prior evidence of or concurrent PM from an ongoing cohort of bone and soft tissue sarcoma (STS) patients. Logistic regression at univariate level was done.
Results
There were 138/630 (22%) patients with metastasis and 66 (10%) had NPM: 50 (8%) patients had PM presenting first, while 16 (3%) had initial NPM. Malignant peripheral nerve sheath tumor, angiosarcoma, rhabdomyosarcoma, synovial sarcoma, and myxoid liposarcoma were six times more likely to develop initial NPM than other subtypes of STS with odds ratio = 6 (95% confidence interval: 1.93–18.65, p value < 0.01). Chest imaging and physical examination were sufficient to identify NPM in all except three bone sarcoma patients.
Conclusions
Patients who develop initial NPM are rare and demonstrate a predilection towards some subtypes of extremity sarcoma. They develop oligometastatic disease, which may be amenable for surgical excision. All isolated or initial NPM in STS patients were discovered by physical examination and standard chest imaging.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.26645</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>extremity ; Lung cancer ; Metastasis ; nonpulmonary ; pulmonary ; Sarcoma ; Surveillance ; visceral metastasis</subject><ispartof>Journal of surgical oncology, 2021-12, Vol.124 (8), p.1491-1498</ispartof><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3305-8ff80f2818acf797d0f16a5f7cec819a8d71a8e98a9dc386ba62ec2b5c7ea3ce3</citedby><cites>FETCH-LOGICAL-c3305-8ff80f2818acf797d0f16a5f7cec819a8d71a8e98a9dc386ba62ec2b5c7ea3ce3</cites><orcidid>0000-0003-3654-4854</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.26645$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.26645$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Hasan, Obada</creatorcontrib><creatorcontrib>Nasir, Momin</creatorcontrib><creatorcontrib>Jessar, Muneeba</creatorcontrib><creatorcontrib>Hashimi, Mustafa</creatorcontrib><creatorcontrib>An, Qiang</creatorcontrib><creatorcontrib>Miller, Benjamin J.</creatorcontrib><title>What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case‐control from a sarcoma referral centre</title><title>Journal of surgical oncology</title><description>Background and Objectives
Nonpulmonary metastases (NPM) are rare, associated with a poorer prognosis, and maybe missed on conventional chest imaging for sarcoma surveillance. We determined (1) the proportion of NPM occurring in isolation or with synchronous or prior pulmonary metastases (PM), and (2) if initial NPM would have been recognized with a standard surveillance protocol.
Methods
Investigators identified patients who developed initial NPM without prior evidence of or concurrent PM from an ongoing cohort of bone and soft tissue sarcoma (STS) patients. Logistic regression at univariate level was done.
Results
There were 138/630 (22%) patients with metastasis and 66 (10%) had NPM: 50 (8%) patients had PM presenting first, while 16 (3%) had initial NPM. Malignant peripheral nerve sheath tumor, angiosarcoma, rhabdomyosarcoma, synovial sarcoma, and myxoid liposarcoma were six times more likely to develop initial NPM than other subtypes of STS with odds ratio = 6 (95% confidence interval: 1.93–18.65, p value < 0.01). Chest imaging and physical examination were sufficient to identify NPM in all except three bone sarcoma patients.
Conclusions
Patients who develop initial NPM are rare and demonstrate a predilection towards some subtypes of extremity sarcoma. They develop oligometastatic disease, which may be amenable for surgical excision. All isolated or initial NPM in STS patients were discovered by physical examination and standard chest imaging.</description><subject>extremity</subject><subject>Lung cancer</subject><subject>Metastasis</subject><subject>nonpulmonary</subject><subject>pulmonary</subject><subject>Sarcoma</subject><subject>Surveillance</subject><subject>visceral metastasis</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10cFqFTEUBuAgFry2LnyDgBtdTJtJ7mSSlZRiq1LoQsXlcG7mxJtrJueazCDd-Qi-jC_kk5j2KoggBAI53wkn-Rl72orTVgh5tit0KrVedw_YqhVWN1ZY85Ctak02696KR-xxKTshhLV6vWI_Pm5h5qHweYs8hs8Yw5Zo5OR5orRf4kQJ8i2fcIZSV5Xk3JJzSJ94SPdtsCmYHN71xKUe_2Wr2FCqJI28kJ_5HEpZkBfIjiZ4yc95wjLjyB0U_Pntu6M0Z4rcZ5o4_HE8o8ecIXKHtY4n7MhDLPjk937MPly-en_xurm-uXpzcX7dOKVE1xjvjfDStAac720_Ct9q6Hzv0JnWghn7FgxaA3Z0yugNaIlObjrXIyiH6pg9P9y7z_RlqYMOUygOY4SEtJRBdloY1UkhK332D93RklOdriqrhVorZap6cVAuUyn1VcM-h6l-8NCK4S7AoQY43AdY7dnBfg0Rb_8Ph7fvbg4dvwBNGKI6</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Hasan, Obada</creator><creator>Nasir, Momin</creator><creator>Jessar, Muneeba</creator><creator>Hashimi, Mustafa</creator><creator>An, Qiang</creator><creator>Miller, Benjamin J.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3654-4854</orcidid></search><sort><creationdate>20211201</creationdate><title>What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case‐control from a sarcoma referral centre</title><author>Hasan, Obada ; Nasir, Momin ; Jessar, Muneeba ; Hashimi, Mustafa ; An, Qiang ; Miller, Benjamin J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3305-8ff80f2818acf797d0f16a5f7cec819a8d71a8e98a9dc386ba62ec2b5c7ea3ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>extremity</topic><topic>Lung cancer</topic><topic>Metastasis</topic><topic>nonpulmonary</topic><topic>pulmonary</topic><topic>Sarcoma</topic><topic>Surveillance</topic><topic>visceral metastasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasan, Obada</creatorcontrib><creatorcontrib>Nasir, Momin</creatorcontrib><creatorcontrib>Jessar, Muneeba</creatorcontrib><creatorcontrib>Hashimi, Mustafa</creatorcontrib><creatorcontrib>An, Qiang</creatorcontrib><creatorcontrib>Miller, Benjamin J.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasan, Obada</au><au>Nasir, Momin</au><au>Jessar, Muneeba</au><au>Hashimi, Mustafa</au><au>An, Qiang</au><au>Miller, Benjamin J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case‐control from a sarcoma referral centre</atitle><jtitle>Journal of surgical oncology</jtitle><date>2021-12-01</date><risdate>2021</risdate><volume>124</volume><issue>8</issue><spage>1491</spage><epage>1498</epage><pages>1491-1498</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Nonpulmonary metastases (NPM) are rare, associated with a poorer prognosis, and maybe missed on conventional chest imaging for sarcoma surveillance. We determined (1) the proportion of NPM occurring in isolation or with synchronous or prior pulmonary metastases (PM), and (2) if initial NPM would have been recognized with a standard surveillance protocol.
Methods
Investigators identified patients who developed initial NPM without prior evidence of or concurrent PM from an ongoing cohort of bone and soft tissue sarcoma (STS) patients. Logistic regression at univariate level was done.
Results
There were 138/630 (22%) patients with metastasis and 66 (10%) had NPM: 50 (8%) patients had PM presenting first, while 16 (3%) had initial NPM. Malignant peripheral nerve sheath tumor, angiosarcoma, rhabdomyosarcoma, synovial sarcoma, and myxoid liposarcoma were six times more likely to develop initial NPM than other subtypes of STS with odds ratio = 6 (95% confidence interval: 1.93–18.65, p value < 0.01). Chest imaging and physical examination were sufficient to identify NPM in all except three bone sarcoma patients.
Conclusions
Patients who develop initial NPM are rare and demonstrate a predilection towards some subtypes of extremity sarcoma. They develop oligometastatic disease, which may be amenable for surgical excision. All isolated or initial NPM in STS patients were discovered by physical examination and standard chest imaging.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/jso.26645</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3654-4854</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | extremity Lung cancer Metastasis nonpulmonary pulmonary Sarcoma Surveillance visceral metastasis |
| title | What is the likelihood of nonpulmonary metastasis occurring in the absence of lung metastasis in bone and soft tissue sarcoma? A nested case‐control from a sarcoma referral centre |
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