Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women
Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in ci...
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| Veröffentlicht in: | The New England journal of medicine 2021-08, Vol.385 (7), p.595-608 |
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| container_title | The New England journal of medicine |
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| creator | Landovitz, Raphael J Donnell, Deborah Clement, Meredith E Hanscom, Brett Cottle, Leslie Coelho, Lara Cabello, Robinson Chariyalertsak, Suwat Dunne, Eileen F Frank, Ian Gallardo-Cartagena, Jorge A Gaur, Aditya H Gonzales, Pedro Tran, Ha V Hinojosa, Juan C Kallas, Esper G Kelley, Colleen F Losso, Marcelo H Madruga, J. Valdez Middelkoop, Keren Phanuphak, Nittaya Santos, Breno Sued, Omar Valencia Huamaní, Javier Overton, Edgar T Swaminathan, Shobha del Rio, Carlos Gulick, Roy M Richardson, Paul Sullivan, Philip Piwowar-Manning, Estelle Marzinke, Mark Hendrix, Craig Li, Maoji Wang, Zhe Marrazzo, Jeanne Daar, Eric Asmelash, Aida Brown, Todd T Anderson, Peter Eshleman, Susan H Bryan, Marcus Blanchette, Cheryl Lucas, Jonathan Psaros, Christina Safren, Steven Sugarman, Jeremy Scott, Hyman Eron, Joseph J Fields, Sheldon D Sista, Nirupama D Gomez-Feliciano, Kailazarid Jennings, Andrea Kofron, Ryan M Holtz, Timothy H Shin, Katherine Rooney, James F Smith, Kimberly Y Spreen, William Margolis, David Rinehart, Alex Adeyeye, Adeola Cohen, Myron S McCauley, Marybeth Grinsztejn, Beatriz |
| description | Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men. |
| doi_str_mv | 10.1056/NEJMoa2101016 |
| format | Article |
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Valdez ; Middelkoop, Keren ; Phanuphak, Nittaya ; Santos, Breno ; Sued, Omar ; Valencia Huamaní, Javier ; Overton, Edgar T ; Swaminathan, Shobha ; del Rio, Carlos ; Gulick, Roy M ; Richardson, Paul ; Sullivan, Philip ; Piwowar-Manning, Estelle ; Marzinke, Mark ; Hendrix, Craig ; Li, Maoji ; Wang, Zhe ; Marrazzo, Jeanne ; Daar, Eric ; Asmelash, Aida ; Brown, Todd T ; Anderson, Peter ; Eshleman, Susan H ; Bryan, Marcus ; Blanchette, Cheryl ; Lucas, Jonathan ; Psaros, Christina ; Safren, Steven ; Sugarman, Jeremy ; Scott, Hyman ; Eron, Joseph J ; Fields, Sheldon D ; Sista, Nirupama D ; Gomez-Feliciano, Kailazarid ; Jennings, Andrea ; Kofron, Ryan M ; Holtz, Timothy H ; Shin, Katherine ; Rooney, James F ; Smith, Kimberly Y ; Spreen, William ; Margolis, David ; Rinehart, Alex ; Adeyeye, Adeola ; Cohen, Myron S ; McCauley, Marybeth ; Grinsztejn, Beatriz</creator><creatorcontrib>Landovitz, Raphael J ; Donnell, Deborah ; Clement, Meredith E ; Hanscom, Brett ; Cottle, Leslie ; Coelho, Lara ; Cabello, Robinson ; Chariyalertsak, Suwat ; Dunne, Eileen F ; Frank, Ian ; Gallardo-Cartagena, Jorge A ; Gaur, Aditya H ; Gonzales, Pedro ; Tran, Ha V ; Hinojosa, Juan C ; Kallas, Esper G ; Kelley, Colleen F ; Losso, Marcelo H ; Madruga, J. Valdez ; Middelkoop, Keren ; Phanuphak, Nittaya ; Santos, Breno ; Sued, Omar ; Valencia Huamaní, Javier ; Overton, Edgar T ; Swaminathan, Shobha ; del Rio, Carlos ; Gulick, Roy M ; Richardson, Paul ; Sullivan, Philip ; Piwowar-Manning, Estelle ; Marzinke, Mark ; Hendrix, Craig ; Li, Maoji ; Wang, Zhe ; Marrazzo, Jeanne ; Daar, Eric ; Asmelash, Aida ; Brown, Todd T ; Anderson, Peter ; Eshleman, Susan H ; Bryan, Marcus ; Blanchette, Cheryl ; Lucas, Jonathan ; Psaros, Christina ; Safren, Steven ; Sugarman, Jeremy ; Scott, Hyman ; Eron, Joseph J ; Fields, Sheldon D ; Sista, Nirupama D ; Gomez-Feliciano, Kailazarid ; Jennings, Andrea ; Kofron, Ryan M ; Holtz, Timothy H ; Shin, Katherine ; Rooney, James F ; Smith, Kimberly Y ; Spreen, William ; Margolis, David ; Rinehart, Alex ; Adeyeye, Adeola ; Cohen, Myron S ; McCauley, Marybeth ; Grinsztejn, Beatriz ; HPTN 083 Study Team</creatorcontrib><description>Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men.</description><identifier>ISSN: 0028-4793</identifier><identifier>ISSN: 1533-4406</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2101016</identifier><identifier>PMID: 34379922</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acquired immune deficiency syndrome ; Administration, Oral ; Adult ; Aged ; AIDS ; Allergies ; Anti-HIV Agents - therapeutic use ; Antigens ; Antiretroviral drugs ; Cisgender ; Delayed-Action Preparations - administration & dosage ; Disease prevention ; Dosage ; Double-Blind Method ; Double-blind studies ; Drug Administration Schedule ; Drug dosages ; Drug Resistance - genetics ; Emtricitabine ; Female ; Gays & lesbians ; Global Health ; Hepatitis ; HIV ; HIV Infections - prevention & control ; HIV Integrase Inhibitors - administration & dosage ; HIV Integrase Inhibitors - adverse effects ; Homosexuality, Male ; Human immunodeficiency virus ; Humans ; Infections ; Infectious Disease ; Infectious diseases ; Injections, Intramuscular - adverse effects ; Integrase ; Intention to Treat Analysis ; Laboratories ; Male ; Medication Adherence ; Mens health ; Middle Aged ; Plasma ; Pre-Exposure Prophylaxis ; Prophylaxis ; Pyridones - administration & dosage ; Pyridones - adverse effects ; Tenofovir ; Tenofovir - therapeutic use ; Transgender Persons ; Womens health ; Young Adult</subject><ispartof>The New England journal of medicine, 2021-08, Vol.385 (7), p.595-608</ispartof><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2021 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1431-8912 ; 0000-0002-6639-5231</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2101016$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2101016$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34379922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landovitz, Raphael J</creatorcontrib><creatorcontrib>Donnell, Deborah</creatorcontrib><creatorcontrib>Clement, Meredith E</creatorcontrib><creatorcontrib>Hanscom, Brett</creatorcontrib><creatorcontrib>Cottle, Leslie</creatorcontrib><creatorcontrib>Coelho, Lara</creatorcontrib><creatorcontrib>Cabello, Robinson</creatorcontrib><creatorcontrib>Chariyalertsak, Suwat</creatorcontrib><creatorcontrib>Dunne, Eileen F</creatorcontrib><creatorcontrib>Frank, Ian</creatorcontrib><creatorcontrib>Gallardo-Cartagena, Jorge A</creatorcontrib><creatorcontrib>Gaur, Aditya H</creatorcontrib><creatorcontrib>Gonzales, Pedro</creatorcontrib><creatorcontrib>Tran, Ha V</creatorcontrib><creatorcontrib>Hinojosa, Juan C</creatorcontrib><creatorcontrib>Kallas, Esper G</creatorcontrib><creatorcontrib>Kelley, Colleen F</creatorcontrib><creatorcontrib>Losso, Marcelo H</creatorcontrib><creatorcontrib>Madruga, J. Valdez</creatorcontrib><creatorcontrib>Middelkoop, Keren</creatorcontrib><creatorcontrib>Phanuphak, Nittaya</creatorcontrib><creatorcontrib>Santos, Breno</creatorcontrib><creatorcontrib>Sued, Omar</creatorcontrib><creatorcontrib>Valencia Huamaní, Javier</creatorcontrib><creatorcontrib>Overton, Edgar T</creatorcontrib><creatorcontrib>Swaminathan, Shobha</creatorcontrib><creatorcontrib>del Rio, Carlos</creatorcontrib><creatorcontrib>Gulick, Roy M</creatorcontrib><creatorcontrib>Richardson, Paul</creatorcontrib><creatorcontrib>Sullivan, Philip</creatorcontrib><creatorcontrib>Piwowar-Manning, Estelle</creatorcontrib><creatorcontrib>Marzinke, Mark</creatorcontrib><creatorcontrib>Hendrix, Craig</creatorcontrib><creatorcontrib>Li, Maoji</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Marrazzo, Jeanne</creatorcontrib><creatorcontrib>Daar, Eric</creatorcontrib><creatorcontrib>Asmelash, Aida</creatorcontrib><creatorcontrib>Brown, Todd T</creatorcontrib><creatorcontrib>Anderson, Peter</creatorcontrib><creatorcontrib>Eshleman, Susan H</creatorcontrib><creatorcontrib>Bryan, Marcus</creatorcontrib><creatorcontrib>Blanchette, Cheryl</creatorcontrib><creatorcontrib>Lucas, Jonathan</creatorcontrib><creatorcontrib>Psaros, Christina</creatorcontrib><creatorcontrib>Safren, Steven</creatorcontrib><creatorcontrib>Sugarman, Jeremy</creatorcontrib><creatorcontrib>Scott, Hyman</creatorcontrib><creatorcontrib>Eron, Joseph J</creatorcontrib><creatorcontrib>Fields, Sheldon D</creatorcontrib><creatorcontrib>Sista, Nirupama D</creatorcontrib><creatorcontrib>Gomez-Feliciano, Kailazarid</creatorcontrib><creatorcontrib>Jennings, Andrea</creatorcontrib><creatorcontrib>Kofron, Ryan M</creatorcontrib><creatorcontrib>Holtz, Timothy H</creatorcontrib><creatorcontrib>Shin, Katherine</creatorcontrib><creatorcontrib>Rooney, James F</creatorcontrib><creatorcontrib>Smith, Kimberly Y</creatorcontrib><creatorcontrib>Spreen, William</creatorcontrib><creatorcontrib>Margolis, David</creatorcontrib><creatorcontrib>Rinehart, Alex</creatorcontrib><creatorcontrib>Adeyeye, Adeola</creatorcontrib><creatorcontrib>Cohen, Myron S</creatorcontrib><creatorcontrib>McCauley, Marybeth</creatorcontrib><creatorcontrib>Grinsztejn, Beatriz</creatorcontrib><creatorcontrib>HPTN 083 Study Team</creatorcontrib><title>Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men.</description><subject>Acquired immune deficiency syndrome</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS</subject><subject>Allergies</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antigens</subject><subject>Antiretroviral drugs</subject><subject>Cisgender</subject><subject>Delayed-Action Preparations - administration & dosage</subject><subject>Disease prevention</subject><subject>Dosage</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Drug Administration Schedule</subject><subject>Drug dosages</subject><subject>Drug Resistance - genetics</subject><subject>Emtricitabine</subject><subject>Female</subject><subject>Gays & lesbians</subject><subject>Global Health</subject><subject>Hepatitis</subject><subject>HIV</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Integrase Inhibitors - administration & dosage</subject><subject>HIV Integrase Inhibitors - adverse effects</subject><subject>Homosexuality, Male</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Injections, Intramuscular - adverse effects</subject><subject>Integrase</subject><subject>Intention to Treat Analysis</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medication Adherence</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Pre-Exposure Prophylaxis</subject><subject>Prophylaxis</subject><subject>Pyridones - administration & dosage</subject><subject>Pyridones - adverse effects</subject><subject>Tenofovir</subject><subject>Tenofovir - therapeutic use</subject><subject>Transgender Persons</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0028-4793</issn><issn>1533-4406</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkE1Lw0AQhhdRbK0evUpABC_R_U72KKG1lVY9VD0um-6kpHQ3dZMU_PdG2x505jDw8jDMPAhdEnxHsJD3z8OnWWUowV3LI9QngrGYcyyPUR9jmsY8UayHzup6hbsiXJ2iHuMsUYrSPhplJq8aWAazLUNUVCEaT96j1wBb8E1Z-aj0UVbWS_AWQjQDHxlvo3kw_pB9VA78OTopzLqGi_0coLfRcJ6N4-nL4yR7mMaOKNXEJmeGK5nnSiluZUFFwaXFYAW2VDHBOFABSZImRoGyDOeLBROSpIpgw0CwAbrd7d2E6rOFutGurBewXhsPVVtrKiROqUq7nwfo-h-6qtrgu-t-KUZZynFHXe2pNndg9SaUzoQvfTDUATc7wLlae1g5TbD-Ma__mGffGLZwpw</recordid><startdate>20210812</startdate><enddate>20210812</enddate><creator>Landovitz, Raphael J</creator><creator>Donnell, Deborah</creator><creator>Clement, Meredith E</creator><creator>Hanscom, Brett</creator><creator>Cottle, Leslie</creator><creator>Coelho, Lara</creator><creator>Cabello, Robinson</creator><creator>Chariyalertsak, Suwat</creator><creator>Dunne, Eileen F</creator><creator>Frank, Ian</creator><creator>Gallardo-Cartagena, Jorge A</creator><creator>Gaur, Aditya H</creator><creator>Gonzales, Pedro</creator><creator>Tran, Ha V</creator><creator>Hinojosa, Juan C</creator><creator>Kallas, Esper G</creator><creator>Kelley, Colleen F</creator><creator>Losso, Marcelo H</creator><creator>Madruga, J. 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Valdez ; Middelkoop, Keren ; Phanuphak, Nittaya ; Santos, Breno ; Sued, Omar ; Valencia Huamaní, Javier ; Overton, Edgar T ; Swaminathan, Shobha ; del Rio, Carlos ; Gulick, Roy M ; Richardson, Paul ; Sullivan, Philip ; Piwowar-Manning, Estelle ; Marzinke, Mark ; Hendrix, Craig ; Li, Maoji ; Wang, Zhe ; Marrazzo, Jeanne ; Daar, Eric ; Asmelash, Aida ; Brown, Todd T ; Anderson, Peter ; Eshleman, Susan H ; Bryan, Marcus ; Blanchette, Cheryl ; Lucas, Jonathan ; Psaros, Christina ; Safren, Steven ; Sugarman, Jeremy ; Scott, Hyman ; Eron, Joseph J ; Fields, Sheldon D ; Sista, Nirupama D ; Gomez-Feliciano, Kailazarid ; Jennings, Andrea ; Kofron, Ryan M ; Holtz, Timothy H ; Shin, Katherine ; Rooney, James F ; Smith, Kimberly Y ; Spreen, William ; Margolis, David ; Rinehart, Alex ; Adeyeye, Adeola ; Cohen, Myron S ; McCauley, Marybeth ; Grinsztejn, Beatriz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-m199t-ab3a496bb9994d6f25f46d0ed50d293534e25e7787a9e9d30bcc35618910a3e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS</topic><topic>Allergies</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antigens</topic><topic>Antiretroviral drugs</topic><topic>Cisgender</topic><topic>Delayed-Action Preparations - administration & dosage</topic><topic>Disease prevention</topic><topic>Dosage</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Drug Administration Schedule</topic><topic>Drug dosages</topic><topic>Drug Resistance - genetics</topic><topic>Emtricitabine</topic><topic>Female</topic><topic>Gays & lesbians</topic><topic>Global Health</topic><topic>Hepatitis</topic><topic>HIV</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Integrase Inhibitors - administration & dosage</topic><topic>HIV Integrase Inhibitors - adverse effects</topic><topic>Homosexuality, Male</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Disease</topic><topic>Infectious diseases</topic><topic>Injections, Intramuscular - adverse effects</topic><topic>Integrase</topic><topic>Intention to Treat Analysis</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medication Adherence</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Pre-Exposure Prophylaxis</topic><topic>Prophylaxis</topic><topic>Pyridones - administration & dosage</topic><topic>Pyridones - adverse effects</topic><topic>Tenofovir</topic><topic>Tenofovir - therapeutic use</topic><topic>Transgender Persons</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landovitz, Raphael J</creatorcontrib><creatorcontrib>Donnell, Deborah</creatorcontrib><creatorcontrib>Clement, Meredith E</creatorcontrib><creatorcontrib>Hanscom, Brett</creatorcontrib><creatorcontrib>Cottle, Leslie</creatorcontrib><creatorcontrib>Coelho, Lara</creatorcontrib><creatorcontrib>Cabello, Robinson</creatorcontrib><creatorcontrib>Chariyalertsak, Suwat</creatorcontrib><creatorcontrib>Dunne, Eileen F</creatorcontrib><creatorcontrib>Frank, Ian</creatorcontrib><creatorcontrib>Gallardo-Cartagena, Jorge A</creatorcontrib><creatorcontrib>Gaur, Aditya H</creatorcontrib><creatorcontrib>Gonzales, Pedro</creatorcontrib><creatorcontrib>Tran, Ha V</creatorcontrib><creatorcontrib>Hinojosa, Juan C</creatorcontrib><creatorcontrib>Kallas, Esper G</creatorcontrib><creatorcontrib>Kelley, Colleen F</creatorcontrib><creatorcontrib>Losso, Marcelo H</creatorcontrib><creatorcontrib>Madruga, J. Valdez</creatorcontrib><creatorcontrib>Middelkoop, Keren</creatorcontrib><creatorcontrib>Phanuphak, Nittaya</creatorcontrib><creatorcontrib>Santos, Breno</creatorcontrib><creatorcontrib>Sued, Omar</creatorcontrib><creatorcontrib>Valencia Huamaní, Javier</creatorcontrib><creatorcontrib>Overton, Edgar T</creatorcontrib><creatorcontrib>Swaminathan, Shobha</creatorcontrib><creatorcontrib>del Rio, Carlos</creatorcontrib><creatorcontrib>Gulick, Roy M</creatorcontrib><creatorcontrib>Richardson, Paul</creatorcontrib><creatorcontrib>Sullivan, Philip</creatorcontrib><creatorcontrib>Piwowar-Manning, Estelle</creatorcontrib><creatorcontrib>Marzinke, Mark</creatorcontrib><creatorcontrib>Hendrix, Craig</creatorcontrib><creatorcontrib>Li, Maoji</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Marrazzo, Jeanne</creatorcontrib><creatorcontrib>Daar, Eric</creatorcontrib><creatorcontrib>Asmelash, Aida</creatorcontrib><creatorcontrib>Brown, Todd T</creatorcontrib><creatorcontrib>Anderson, Peter</creatorcontrib><creatorcontrib>Eshleman, Susan H</creatorcontrib><creatorcontrib>Bryan, Marcus</creatorcontrib><creatorcontrib>Blanchette, Cheryl</creatorcontrib><creatorcontrib>Lucas, Jonathan</creatorcontrib><creatorcontrib>Psaros, Christina</creatorcontrib><creatorcontrib>Safren, Steven</creatorcontrib><creatorcontrib>Sugarman, Jeremy</creatorcontrib><creatorcontrib>Scott, Hyman</creatorcontrib><creatorcontrib>Eron, Joseph J</creatorcontrib><creatorcontrib>Fields, Sheldon D</creatorcontrib><creatorcontrib>Sista, Nirupama D</creatorcontrib><creatorcontrib>Gomez-Feliciano, Kailazarid</creatorcontrib><creatorcontrib>Jennings, Andrea</creatorcontrib><creatorcontrib>Kofron, Ryan M</creatorcontrib><creatorcontrib>Holtz, Timothy H</creatorcontrib><creatorcontrib>Shin, Katherine</creatorcontrib><creatorcontrib>Rooney, James F</creatorcontrib><creatorcontrib>Smith, Kimberly Y</creatorcontrib><creatorcontrib>Spreen, William</creatorcontrib><creatorcontrib>Margolis, David</creatorcontrib><creatorcontrib>Rinehart, Alex</creatorcontrib><creatorcontrib>Adeyeye, Adeola</creatorcontrib><creatorcontrib>Cohen, Myron S</creatorcontrib><creatorcontrib>McCauley, Marybeth</creatorcontrib><creatorcontrib>Grinsztejn, Beatriz</creatorcontrib><creatorcontrib>HPTN 083 Study Team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landovitz, Raphael J</au><au>Donnell, Deborah</au><au>Clement, Meredith E</au><au>Hanscom, Brett</au><au>Cottle, Leslie</au><au>Coelho, Lara</au><au>Cabello, Robinson</au><au>Chariyalertsak, Suwat</au><au>Dunne, Eileen F</au><au>Frank, Ian</au><au>Gallardo-Cartagena, Jorge A</au><au>Gaur, Aditya H</au><au>Gonzales, Pedro</au><au>Tran, Ha V</au><au>Hinojosa, Juan C</au><au>Kallas, Esper G</au><au>Kelley, Colleen F</au><au>Losso, Marcelo H</au><au>Madruga, J. Valdez</au><au>Middelkoop, Keren</au><au>Phanuphak, Nittaya</au><au>Santos, Breno</au><au>Sued, Omar</au><au>Valencia Huamaní, Javier</au><au>Overton, Edgar T</au><au>Swaminathan, Shobha</au><au>del Rio, Carlos</au><au>Gulick, Roy M</au><au>Richardson, Paul</au><au>Sullivan, Philip</au><au>Piwowar-Manning, Estelle</au><au>Marzinke, Mark</au><au>Hendrix, Craig</au><au>Li, Maoji</au><au>Wang, Zhe</au><au>Marrazzo, Jeanne</au><au>Daar, Eric</au><au>Asmelash, Aida</au><au>Brown, Todd T</au><au>Anderson, Peter</au><au>Eshleman, Susan H</au><au>Bryan, Marcus</au><au>Blanchette, Cheryl</au><au>Lucas, Jonathan</au><au>Psaros, Christina</au><au>Safren, Steven</au><au>Sugarman, Jeremy</au><au>Scott, Hyman</au><au>Eron, Joseph J</au><au>Fields, Sheldon D</au><au>Sista, Nirupama D</au><au>Gomez-Feliciano, Kailazarid</au><au>Jennings, Andrea</au><au>Kofron, Ryan M</au><au>Holtz, Timothy H</au><au>Shin, Katherine</au><au>Rooney, James F</au><au>Smith, Kimberly Y</au><au>Spreen, William</au><au>Margolis, David</au><au>Rinehart, Alex</au><au>Adeyeye, Adeola</au><au>Cohen, Myron S</au><au>McCauley, Marybeth</au><au>Grinsztejn, Beatriz</au><aucorp>HPTN 083 Study Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2021-08-12</date><risdate>2021</risdate><volume>385</volume><issue>7</issue><spage>595</spage><epage>608</epage><pages>595-608</pages><issn>0028-4793</issn><issn>1533-4406</issn><eissn>1533-4406</eissn><abstract>Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>34379922</pmid><doi>10.1056/NEJMoa2101016</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1431-8912</orcidid><orcidid>https://orcid.org/0000-0002-6639-5231</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-08, Vol.385 (7), p.595-608 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2560829879 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Acquired immune deficiency syndrome Administration, Oral Adult Aged AIDS Allergies Anti-HIV Agents - therapeutic use Antigens Antiretroviral drugs Cisgender Delayed-Action Preparations - administration & dosage Disease prevention Dosage Double-Blind Method Double-blind studies Drug Administration Schedule Drug dosages Drug Resistance - genetics Emtricitabine Female Gays & lesbians Global Health Hepatitis HIV HIV Infections - prevention & control HIV Integrase Inhibitors - administration & dosage HIV Integrase Inhibitors - adverse effects Homosexuality, Male Human immunodeficiency virus Humans Infections Infectious Disease Infectious diseases Injections, Intramuscular - adverse effects Integrase Intention to Treat Analysis Laboratories Male Medication Adherence Mens health Middle Aged Plasma Pre-Exposure Prophylaxis Prophylaxis Pyridones - administration & dosage Pyridones - adverse effects Tenofovir Tenofovir - therapeutic use Transgender Persons Womens health Young Adult |
| title | Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women |
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