Increased risk of Barrett’s oesophagus and related neoplasia in individuals with a positive family history
Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention strategies. We aimed to determine whether individuals with a positive family history of Barrett’s oesoph...
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| Veröffentlicht in: | European journal of cancer (1990) 2021-09, Vol.155, p.116-126 |
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| container_title | European journal of cancer (1990) |
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| creator | Peters, Yonne Huibertse, Lotte J. Schrauwen, Ruud W.M. Tan, Adriaan C. van der Post, Rachel S. Siersema, Peter D. |
| description | Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention strategies. We aimed to determine whether individuals with a positive family history of Barrett’s oesophagus (BE) and EAC are at an increased risk of oesophageal neoplasia.
In a multi-centre case–control study, BE patients with or without related oesophageal neoplasia and randomly selected population controls filled out a questionnaire to collect information on family history and other risk factors for BE and EAC. Positive family history was defined as having ≥1 first-degree relative with BE or EAC whose diagnosis was histologically confirmed in the Dutch nationwide histopathology database.
We included 480 BE patients and 420 controls without BE who had a total of 6393 first-degree relatives. A pathologically confirmed positive family history was significantly higher in BE patients compared with controls (6.5% versus 0.9; p |
| doi_str_mv | 10.1016/j.ejca.2021.07.007 |
| format | Article |
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In a multi-centre case–control study, BE patients with or without related oesophageal neoplasia and randomly selected population controls filled out a questionnaire to collect information on family history and other risk factors for BE and EAC. Positive family history was defined as having ≥1 first-degree relative with BE or EAC whose diagnosis was histologically confirmed in the Dutch nationwide histopathology database.
We included 480 BE patients and 420 controls without BE who had a total of 6393 first-degree relatives. A pathologically confirmed positive family history was significantly higher in BE patients compared with controls (6.5% versus 0.9; p < 0.001). Positive family history was independently associated with an increased risk of BE (OR 5.04; 95% CI 1.45–17.58; p = 0.01) after adjusting for known risk factors, such as gastroesophageal reflux disease and body mass index, and family size.
We found that familial clustering of BE and EAC is present in 6.5% of Dutch BE patients. Subjects with ≥1 first-degree relative with BE or EAC have a 5-fold increased risk of BE and EAC. These findings emphasize the importance of a detailed family history in patients with BE or EAC to identify individuals at increased risk who may benefit from early detection strategies to prevent EAC-related mortality.
•No consensus on the need for screening of individuals with a family history of BE/EAC.•Familial clustering is seen in 6.5% of patients with BE, with 14% of FDR affected.•A positive family history increases the risk of BE and related neoplasia by 5-fold.•It is important to obtain family history in all patients with BE and EAC.•Family history should be incorporated in future screening guidelines.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2021.07.007</identifier><identifier>PMID: 34375895</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenocarcinoma ; Aged ; Barrett Esophagus - diagnosis ; Barrett Esophagus - physiopathology ; Barrett's esophagus ; Barrett’s oesophagus ; Body mass ; Body mass index ; Body size ; Case-Control Studies ; Clustering ; Detection ; Esophageal cancer ; Family history ; Family size ; Female ; Gastroesophageal reflux ; Genetics ; Histopathology ; Humans ; Male ; Medical History Taking - methods ; Middle Aged ; Oesophageal cancer ; PALGA ; Population control ; Risk analysis ; Risk Factors ; Surveys and Questionnaires</subject><ispartof>European journal of cancer (1990), 2021-09, Vol.155, p.116-126</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Sep 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-e1d62033601cdd0eac7c4fa475519204c0dec97161a8bbd7f921675a0e9c4e373</citedby><cites>FETCH-LOGICAL-c428t-e1d62033601cdd0eac7c4fa475519204c0dec97161a8bbd7f921675a0e9c4e373</cites><orcidid>0000-0002-6940-8499 ; 0000-0002-0789-097X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejca.2021.07.007$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34375895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peters, Yonne</creatorcontrib><creatorcontrib>Huibertse, Lotte J.</creatorcontrib><creatorcontrib>Schrauwen, Ruud W.M.</creatorcontrib><creatorcontrib>Tan, Adriaan C.</creatorcontrib><creatorcontrib>van der Post, Rachel S.</creatorcontrib><creatorcontrib>Siersema, Peter D.</creatorcontrib><title>Increased risk of Barrett’s oesophagus and related neoplasia in individuals with a positive family history</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention strategies. We aimed to determine whether individuals with a positive family history of Barrett’s oesophagus (BE) and EAC are at an increased risk of oesophageal neoplasia.
In a multi-centre case–control study, BE patients with or without related oesophageal neoplasia and randomly selected population controls filled out a questionnaire to collect information on family history and other risk factors for BE and EAC. Positive family history was defined as having ≥1 first-degree relative with BE or EAC whose diagnosis was histologically confirmed in the Dutch nationwide histopathology database.
We included 480 BE patients and 420 controls without BE who had a total of 6393 first-degree relatives. A pathologically confirmed positive family history was significantly higher in BE patients compared with controls (6.5% versus 0.9; p < 0.001). Positive family history was independently associated with an increased risk of BE (OR 5.04; 95% CI 1.45–17.58; p = 0.01) after adjusting for known risk factors, such as gastroesophageal reflux disease and body mass index, and family size.
We found that familial clustering of BE and EAC is present in 6.5% of Dutch BE patients. Subjects with ≥1 first-degree relative with BE or EAC have a 5-fold increased risk of BE and EAC. These findings emphasize the importance of a detailed family history in patients with BE or EAC to identify individuals at increased risk who may benefit from early detection strategies to prevent EAC-related mortality.
•No consensus on the need for screening of individuals with a family history of BE/EAC.•Familial clustering is seen in 6.5% of patients with BE, with 14% of FDR affected.•A positive family history increases the risk of BE and related neoplasia by 5-fold.•It is important to obtain family history in all patients with BE and EAC.•Family history should be incorporated in future screening guidelines.</description><subject>Adenocarcinoma</subject><subject>Aged</subject><subject>Barrett Esophagus - diagnosis</subject><subject>Barrett Esophagus - physiopathology</subject><subject>Barrett's esophagus</subject><subject>Barrett’s oesophagus</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Case-Control Studies</subject><subject>Clustering</subject><subject>Detection</subject><subject>Esophageal cancer</subject><subject>Family history</subject><subject>Family size</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Genetics</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical History Taking - methods</subject><subject>Middle Aged</subject><subject>Oesophageal cancer</subject><subject>PALGA</subject><subject>Population control</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90bGO1DAQBmALgbi9gxegQJZoaBLGjhPHEg2c4DjpJBqoLa89YR2ycbCdRdvxGrweT4JXe1BQIFly882v0fyEPGNQM2Ddq7HG0ZqaA2c1yBpAPiAb1ktVQd_yh2QDqlVVD0JdkMuURiiiF_CYXDSikW2v2g2Zbmcb0SR0NPr0lYaBvjUxYs6_fvxMNGAKy858WRM1cyE4mVzojGGZTPKG-rk85w_erWZK9LvPO2roEpLP_oB0MHs_HenOpxzi8Ql5NBSFT-__K_L5_btP1x-qu483t9dv7ioreJ8rZK7j0DQdMOscoLHSisEI2bZMcRAWHFolWcdMv906OSjOOtkaQGUFNrK5Ii_PuUsM31ZMWe99sjhNpiy-Js3bDriSousKffEPHcMa57JdUT1IrqAVRfGzsjGkFHHQS_R7E4-agT51oUd96kKfutAgdbl0GXp-H71u9-j-jvw5fgGvzwDLLQ4eo07W42zR-Yg2axf8__J_A1IInB0</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Peters, Yonne</creator><creator>Huibertse, Lotte J.</creator><creator>Schrauwen, Ruud W.M.</creator><creator>Tan, Adriaan C.</creator><creator>van der Post, Rachel S.</creator><creator>Siersema, Peter D.</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6940-8499</orcidid><orcidid>https://orcid.org/0000-0002-0789-097X</orcidid></search><sort><creationdate>202109</creationdate><title>Increased risk of Barrett’s oesophagus and related neoplasia in individuals with a positive family history</title><author>Peters, Yonne ; Huibertse, Lotte J. ; Schrauwen, Ruud W.M. ; Tan, Adriaan C. ; van der Post, Rachel S. ; Siersema, Peter D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-e1d62033601cdd0eac7c4fa475519204c0dec97161a8bbd7f921675a0e9c4e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma</topic><topic>Aged</topic><topic>Barrett Esophagus - diagnosis</topic><topic>Barrett Esophagus - physiopathology</topic><topic>Barrett's esophagus</topic><topic>Barrett’s oesophagus</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Case-Control Studies</topic><topic>Clustering</topic><topic>Detection</topic><topic>Esophageal cancer</topic><topic>Family history</topic><topic>Family size</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Genetics</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical History Taking - methods</topic><topic>Middle Aged</topic><topic>Oesophageal cancer</topic><topic>PALGA</topic><topic>Population control</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peters, Yonne</creatorcontrib><creatorcontrib>Huibertse, Lotte J.</creatorcontrib><creatorcontrib>Schrauwen, Ruud W.M.</creatorcontrib><creatorcontrib>Tan, Adriaan C.</creatorcontrib><creatorcontrib>van der Post, Rachel S.</creatorcontrib><creatorcontrib>Siersema, Peter D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peters, Yonne</au><au>Huibertse, Lotte J.</au><au>Schrauwen, Ruud W.M.</au><au>Tan, Adriaan C.</au><au>van der Post, Rachel S.</au><au>Siersema, Peter D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased risk of Barrett’s oesophagus and related neoplasia in individuals with a positive family history</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2021-09</date><risdate>2021</risdate><volume>155</volume><spage>116</spage><epage>126</epage><pages>116-126</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention strategies. We aimed to determine whether individuals with a positive family history of Barrett’s oesophagus (BE) and EAC are at an increased risk of oesophageal neoplasia.
In a multi-centre case–control study, BE patients with or without related oesophageal neoplasia and randomly selected population controls filled out a questionnaire to collect information on family history and other risk factors for BE and EAC. Positive family history was defined as having ≥1 first-degree relative with BE or EAC whose diagnosis was histologically confirmed in the Dutch nationwide histopathology database.
We included 480 BE patients and 420 controls without BE who had a total of 6393 first-degree relatives. A pathologically confirmed positive family history was significantly higher in BE patients compared with controls (6.5% versus 0.9; p < 0.001). Positive family history was independently associated with an increased risk of BE (OR 5.04; 95% CI 1.45–17.58; p = 0.01) after adjusting for known risk factors, such as gastroesophageal reflux disease and body mass index, and family size.
We found that familial clustering of BE and EAC is present in 6.5% of Dutch BE patients. Subjects with ≥1 first-degree relative with BE or EAC have a 5-fold increased risk of BE and EAC. These findings emphasize the importance of a detailed family history in patients with BE or EAC to identify individuals at increased risk who may benefit from early detection strategies to prevent EAC-related mortality.
•No consensus on the need for screening of individuals with a family history of BE/EAC.•Familial clustering is seen in 6.5% of patients with BE, with 14% of FDR affected.•A positive family history increases the risk of BE and related neoplasia by 5-fold.•It is important to obtain family history in all patients with BE and EAC.•Family history should be incorporated in future screening guidelines.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34375895</pmid><doi>10.1016/j.ejca.2021.07.007</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6940-8499</orcidid><orcidid>https://orcid.org/0000-0002-0789-097X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Aged Barrett Esophagus - diagnosis Barrett Esophagus - physiopathology Barrett's esophagus Barrett’s oesophagus Body mass Body mass index Body size Case-Control Studies Clustering Detection Esophageal cancer Family history Family size Female Gastroesophageal reflux Genetics Histopathology Humans Male Medical History Taking - methods Middle Aged Oesophageal cancer PALGA Population control Risk analysis Risk Factors Surveys and Questionnaires |
| title | Increased risk of Barrett’s oesophagus and related neoplasia in individuals with a positive family history |
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