Drug repositioning based on the heterogeneous information fusion graph convolutional network

In silico reuse of old drugs (also known as drug repositioning) to treat common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked drugs, with potentially lower overall development costs and shorter development timelines. Therefore, there is...

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Veröffentlicht in:	Briefings in bioinformatics 2021-11, Vol.22 (6)
Hauptverfasser:	Cai, Lijun, Lu, Changcheng, Xu, Junlin, Meng, Yajie, Wang, Peng, Fu, Xiangzheng, Zeng, Xiangxiang, Su, Yansen
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers Databases, Pharmaceutical Drug Development - methods Drug Discovery - methods Drug Repositioning Humans Models, Molecular Reproducibility of Results ROC Curve Structure-Activity Relationship
Online-Zugang:	Volltext
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