Long‐term chronological changes in renal function and functional renal volume after nephron‐sparing surgery: A prospective observational study
Objectives To investigate long‐term chronological changes in functional renal volume and renal function after nephron‐sparing surgery, and factors that contribute to the progression of postoperative chronic kidney disease. Methods A total of 80 patients who underwent nephron‐sparing surgery were enr...
Gespeichert in:
| Veröffentlicht in: | International journal of urology 2021-11, Vol.28 (11), p.1112-1119 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1119 |
|---|---|
| container_issue | 11 |
| container_start_page | 1112 |
| container_title | International journal of urology |
| container_volume | 28 |
| creator | Onishi, Kenta Tanaka, Nobumichi Hori, Shunta Miyake, Makito Nakai, Yasushi Anai, Satoshi Hosokawa, Yukinari Mibu, Hisakazu Marugami, Nagaaki Fujimoto, Kiyohide |
| description | Objectives
To investigate long‐term chronological changes in functional renal volume and renal function after nephron‐sparing surgery, and factors that contribute to the progression of postoperative chronic kidney disease.
Methods
A total of 80 patients who underwent nephron‐sparing surgery were enrolled in this prospective observational study. The renal function deterioration group was defined as patients whose estimated glomerular filtration rate at 5 postoperative years decreased by ≥20% relative to that before surgery.
Results
The predicted estimated glomerular filtration rate, calculated based on the functional renal volume at 5 postoperative years, was strongly correlated with the postoperative estimated glomerular filtration rate (Spearman’s ρ = 0.89, P |
| doi_str_mv | 10.1111/iju.14658 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2560296617</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2591369788</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3148-effd191f49a1d0c367e2c67993592fe0d3786f822a1acf809bb4dd461bf9acc93</originalsourceid><addsrcrecordid>eNp1kbFu2zAQhokiBeq4HfoGBLIkg2weJVNktiBIkxQGujSzQFNHVYZMKqTlQFseocgj9klCV0GGAuVC3PG7D0f8hHwFtoB0lu12WEAhVvIDmUFR8Iyzgp-QGVOgMgkl_0ROY9wyBjkHOSMva--aP8-_9xh21PwK3vnON63RXaq0azDS1tGALjXs4My-9Y5qV78XqT-9Hnw37JBqm1TUYX90JXHsdWhdQ-MQGgzjJb2iffCxxzR9QOo3EcNBv5nifqjHz-Sj1V3EL2_3nDx8u_l5fZetf9zeX1-tM5NDITO0tgYFtlAaamZyUSI3olQqXylukdV5KYWVnGvQxkqmNpuirgsBG6u0MSqfk_PJm_Z5HDDuq10bDXadduiHWPGVYFwJAWVCz_5Bt34IaeMjpSAXqpQyURcTZdIHY0Bb9aHd6TBWwKpjOlVKp_qbTmKXE_vUdjj-H6zuvz9ME6_pJJbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2591369788</pqid></control><display><type>article</type><title>Long‐term chronological changes in renal function and functional renal volume after nephron‐sparing surgery: A prospective observational study</title><source>Access via Wiley Online Library</source><creator>Onishi, Kenta ; Tanaka, Nobumichi ; Hori, Shunta ; Miyake, Makito ; Nakai, Yasushi ; Anai, Satoshi ; Hosokawa, Yukinari ; Mibu, Hisakazu ; Marugami, Nagaaki ; Fujimoto, Kiyohide</creator><creatorcontrib>Onishi, Kenta ; Tanaka, Nobumichi ; Hori, Shunta ; Miyake, Makito ; Nakai, Yasushi ; Anai, Satoshi ; Hosokawa, Yukinari ; Mibu, Hisakazu ; Marugami, Nagaaki ; Fujimoto, Kiyohide</creatorcontrib><description>Objectives
To investigate long‐term chronological changes in functional renal volume and renal function after nephron‐sparing surgery, and factors that contribute to the progression of postoperative chronic kidney disease.
Methods
A total of 80 patients who underwent nephron‐sparing surgery were enrolled in this prospective observational study. The renal function deterioration group was defined as patients whose estimated glomerular filtration rate at 5 postoperative years decreased by ≥20% relative to that before surgery.
Results
The predicted estimated glomerular filtration rate, calculated based on the functional renal volume at 5 postoperative years, was strongly correlated with the postoperative estimated glomerular filtration rate (Spearman’s ρ = 0.89, P < 0.001). The rate of new‐onset stage IIIb chronic kidney disease was significantly higher in the renal function deterioration group than in the stable renal function group (P < 0.001). Multivariate analysis identified proteinuria (P = 0.017), small preoperative total functional renal volume (≤250 mL, P = 0.046) and large tumor volume (≥4.5 mL, P = 0.036) as independent factors associated with renal function deterioration.
Conclusions
Our findings show that the functional renal volume is significantly associated with renal function, even in the long‐term postoperative period. Additionally, for patients with preoperative proteinuria, large tumor volume and small total preoperative functional renal volume, both oncological follow ups and medical interventions, including prevention of lifestyle‐related diseases, might prevent the progression of chronic kidney disease.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.14658</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>chronic kidney disease ; Glomerular filtration rate ; Kidney diseases ; Multivariate analysis ; nephron‐sparing surgery ; Observational studies ; Patients ; Proteinuria ; Renal function ; Surgery ; tumor volume ; Tumors</subject><ispartof>International journal of urology, 2021-11, Vol.28 (11), p.1112-1119</ispartof><rights>2021 The Japanese Urological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3148-effd191f49a1d0c367e2c67993592fe0d3786f822a1acf809bb4dd461bf9acc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.14658$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.14658$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Onishi, Kenta</creatorcontrib><creatorcontrib>Tanaka, Nobumichi</creatorcontrib><creatorcontrib>Hori, Shunta</creatorcontrib><creatorcontrib>Miyake, Makito</creatorcontrib><creatorcontrib>Nakai, Yasushi</creatorcontrib><creatorcontrib>Anai, Satoshi</creatorcontrib><creatorcontrib>Hosokawa, Yukinari</creatorcontrib><creatorcontrib>Mibu, Hisakazu</creatorcontrib><creatorcontrib>Marugami, Nagaaki</creatorcontrib><creatorcontrib>Fujimoto, Kiyohide</creatorcontrib><title>Long‐term chronological changes in renal function and functional renal volume after nephron‐sparing surgery: A prospective observational study</title><title>International journal of urology</title><description>Objectives
To investigate long‐term chronological changes in functional renal volume and renal function after nephron‐sparing surgery, and factors that contribute to the progression of postoperative chronic kidney disease.
Methods
A total of 80 patients who underwent nephron‐sparing surgery were enrolled in this prospective observational study. The renal function deterioration group was defined as patients whose estimated glomerular filtration rate at 5 postoperative years decreased by ≥20% relative to that before surgery.
Results
The predicted estimated glomerular filtration rate, calculated based on the functional renal volume at 5 postoperative years, was strongly correlated with the postoperative estimated glomerular filtration rate (Spearman’s ρ = 0.89, P < 0.001). The rate of new‐onset stage IIIb chronic kidney disease was significantly higher in the renal function deterioration group than in the stable renal function group (P < 0.001). Multivariate analysis identified proteinuria (P = 0.017), small preoperative total functional renal volume (≤250 mL, P = 0.046) and large tumor volume (≥4.5 mL, P = 0.036) as independent factors associated with renal function deterioration.
Conclusions
Our findings show that the functional renal volume is significantly associated with renal function, even in the long‐term postoperative period. Additionally, for patients with preoperative proteinuria, large tumor volume and small total preoperative functional renal volume, both oncological follow ups and medical interventions, including prevention of lifestyle‐related diseases, might prevent the progression of chronic kidney disease.</description><subject>chronic kidney disease</subject><subject>Glomerular filtration rate</subject><subject>Kidney diseases</subject><subject>Multivariate analysis</subject><subject>nephron‐sparing surgery</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Proteinuria</subject><subject>Renal function</subject><subject>Surgery</subject><subject>tumor volume</subject><subject>Tumors</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kbFu2zAQhokiBeq4HfoGBLIkg2weJVNktiBIkxQGujSzQFNHVYZMKqTlQFseocgj9klCV0GGAuVC3PG7D0f8hHwFtoB0lu12WEAhVvIDmUFR8Iyzgp-QGVOgMgkl_0ROY9wyBjkHOSMva--aP8-_9xh21PwK3vnON63RXaq0azDS1tGALjXs4My-9Y5qV78XqT-9Hnw37JBqm1TUYX90JXHsdWhdQ-MQGgzjJb2iffCxxzR9QOo3EcNBv5nifqjHz-Sj1V3EL2_3nDx8u_l5fZetf9zeX1-tM5NDITO0tgYFtlAaamZyUSI3olQqXylukdV5KYWVnGvQxkqmNpuirgsBG6u0MSqfk_PJm_Z5HDDuq10bDXadduiHWPGVYFwJAWVCz_5Bt34IaeMjpSAXqpQyURcTZdIHY0Bb9aHd6TBWwKpjOlVKp_qbTmKXE_vUdjj-H6zuvz9ME6_pJJbw</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Onishi, Kenta</creator><creator>Tanaka, Nobumichi</creator><creator>Hori, Shunta</creator><creator>Miyake, Makito</creator><creator>Nakai, Yasushi</creator><creator>Anai, Satoshi</creator><creator>Hosokawa, Yukinari</creator><creator>Mibu, Hisakazu</creator><creator>Marugami, Nagaaki</creator><creator>Fujimoto, Kiyohide</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Long‐term chronological changes in renal function and functional renal volume after nephron‐sparing surgery: A prospective observational study</title><author>Onishi, Kenta ; Tanaka, Nobumichi ; Hori, Shunta ; Miyake, Makito ; Nakai, Yasushi ; Anai, Satoshi ; Hosokawa, Yukinari ; Mibu, Hisakazu ; Marugami, Nagaaki ; Fujimoto, Kiyohide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3148-effd191f49a1d0c367e2c67993592fe0d3786f822a1acf809bb4dd461bf9acc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>chronic kidney disease</topic><topic>Glomerular filtration rate</topic><topic>Kidney diseases</topic><topic>Multivariate analysis</topic><topic>nephron‐sparing surgery</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Proteinuria</topic><topic>Renal function</topic><topic>Surgery</topic><topic>tumor volume</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Onishi, Kenta</creatorcontrib><creatorcontrib>Tanaka, Nobumichi</creatorcontrib><creatorcontrib>Hori, Shunta</creatorcontrib><creatorcontrib>Miyake, Makito</creatorcontrib><creatorcontrib>Nakai, Yasushi</creatorcontrib><creatorcontrib>Anai, Satoshi</creatorcontrib><creatorcontrib>Hosokawa, Yukinari</creatorcontrib><creatorcontrib>Mibu, Hisakazu</creatorcontrib><creatorcontrib>Marugami, Nagaaki</creatorcontrib><creatorcontrib>Fujimoto, Kiyohide</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Onishi, Kenta</au><au>Tanaka, Nobumichi</au><au>Hori, Shunta</au><au>Miyake, Makito</au><au>Nakai, Yasushi</au><au>Anai, Satoshi</au><au>Hosokawa, Yukinari</au><au>Mibu, Hisakazu</au><au>Marugami, Nagaaki</au><au>Fujimoto, Kiyohide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term chronological changes in renal function and functional renal volume after nephron‐sparing surgery: A prospective observational study</atitle><jtitle>International journal of urology</jtitle><date>2021-11</date><risdate>2021</risdate><volume>28</volume><issue>11</issue><spage>1112</spage><epage>1119</epage><pages>1112-1119</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To investigate long‐term chronological changes in functional renal volume and renal function after nephron‐sparing surgery, and factors that contribute to the progression of postoperative chronic kidney disease.
Methods
A total of 80 patients who underwent nephron‐sparing surgery were enrolled in this prospective observational study. The renal function deterioration group was defined as patients whose estimated glomerular filtration rate at 5 postoperative years decreased by ≥20% relative to that before surgery.
Results
The predicted estimated glomerular filtration rate, calculated based on the functional renal volume at 5 postoperative years, was strongly correlated with the postoperative estimated glomerular filtration rate (Spearman’s ρ = 0.89, P < 0.001). The rate of new‐onset stage IIIb chronic kidney disease was significantly higher in the renal function deterioration group than in the stable renal function group (P < 0.001). Multivariate analysis identified proteinuria (P = 0.017), small preoperative total functional renal volume (≤250 mL, P = 0.046) and large tumor volume (≥4.5 mL, P = 0.036) as independent factors associated with renal function deterioration.
Conclusions
Our findings show that the functional renal volume is significantly associated with renal function, even in the long‐term postoperative period. Additionally, for patients with preoperative proteinuria, large tumor volume and small total preoperative functional renal volume, both oncological follow ups and medical interventions, including prevention of lifestyle‐related diseases, might prevent the progression of chronic kidney disease.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/iju.14658</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-8172 |
| ispartof | International journal of urology, 2021-11, Vol.28 (11), p.1112-1119 |
| issn | 0919-8172 1442-2042 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2560296617 |
| source | Access via Wiley Online Library |
| subjects | chronic kidney disease Glomerular filtration rate Kidney diseases Multivariate analysis nephron‐sparing surgery Observational studies Patients Proteinuria Renal function Surgery tumor volume Tumors |
| title | Long‐term chronological changes in renal function and functional renal volume after nephron‐sparing surgery: A prospective observational study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T03%3A16%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long%E2%80%90term%20chronological%20changes%20in%20renal%20function%20and%20functional%20renal%20volume%20after%20nephron%E2%80%90sparing%20surgery:%20A%20prospective%20observational%20study&rft.jtitle=International%20journal%20of%20urology&rft.au=Onishi,%20Kenta&rft.date=2021-11&rft.volume=28&rft.issue=11&rft.spage=1112&rft.epage=1119&rft.pages=1112-1119&rft.issn=0919-8172&rft.eissn=1442-2042&rft_id=info:doi/10.1111/iju.14658&rft_dat=%3Cproquest_cross%3E2591369788%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2591369788&rft_id=info:pmid/&rfr_iscdi=true |