Molecular mechanism of hippocampal long-term potentiation – Towards multiscale understanding of learning and memory

•The expression mechanism of long-term potentiation is now explained in molecular term by AMPA-R trafficking.•However the mechanism to maintain the enhanced transmission despite protein diffusion and turnover still remains elusive.•A recent emergence of liquid-liquid phase separation of synaptic mol...

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Veröffentlicht in:	Neuroscience research 2022-02, Vol.175, p.3-15
1. Verfasser:	Hayashi, Yasunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Ca2+/calmodulin-dependent protein kinase II Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cytoskeleton Glutamate receptor Hippocampus - metabolism Learning - physiology Learning and memory Long-term potentiation Long-Term Potentiation - physiology Synapses - metabolism Synaptic plasticity
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