Exosomal Noncoding RNAs in Hepatobiliary Cancer: A Rising Star
Hepatobiliary cancers are a heterogeneous group of malignancies with a dismal prognosis. Despite intensive research efforts focused on these tumors, methods for early diagnosis and effective targeted therapies are still lacking. Exosomes, released by most cells, exist in all kinds of body fluids and...
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| Veröffentlicht in: | Molecular cancer therapeutics 2021-10, Vol.20 (10), p.1777-1788 |
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| container_title | Molecular cancer therapeutics |
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| creator | Zheng, Wangyang Ji, Daolin Zhou, Yongxu Yu, Liang Huang, Peng Zheng, Yuling Meng, Nanfeng Wang, Hang Bai, Xue Huang, ZiYue Chen, Wangming Yam, Judy W P Xu, Yi Cui, Yunfu |
| description | Hepatobiliary cancers are a heterogeneous group of malignancies with a dismal prognosis. Despite intensive research efforts focused on these tumors, methods for early diagnosis and effective targeted therapies are still lacking. Exosomes, released by most cells, exist in all kinds of body fluids and play an important role in cell-to-cell communication. They are small membranous vesicles containing biological molecules, such as noncoding RNAs (ncRNA), which are not translated into proteins, but they exert effects on the regulation of gene transcription and translation. There is growing evidence for the essential roles of ncRNAs in exosomes in both physiologic and pathologic conditions of hepatobiliary cancers. They have been identified as sensitive diagnostic biomarkers as well as potential therapeutic targets. The present review discusses recent findings in the cross-talk between hepatobiliary cancers cells and the surrounding cells of the microenvironment and discuss their potential clinical usage. |
| doi_str_mv | 10.1158/1535-7163.MCT-21-0363 |
| format | Article |
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Despite intensive research efforts focused on these tumors, methods for early diagnosis and effective targeted therapies are still lacking. Exosomes, released by most cells, exist in all kinds of body fluids and play an important role in cell-to-cell communication. They are small membranous vesicles containing biological molecules, such as noncoding RNAs (ncRNA), which are not translated into proteins, but they exert effects on the regulation of gene transcription and translation. There is growing evidence for the essential roles of ncRNAs in exosomes in both physiologic and pathologic conditions of hepatobiliary cancers. They have been identified as sensitive diagnostic biomarkers as well as potential therapeutic targets. The present review discusses recent findings in the cross-talk between hepatobiliary cancers cells and the surrounding cells of the microenvironment and discuss their potential clinical usage.</description><identifier>ISSN: 1535-7163</identifier><identifier>EISSN: 1538-8514</identifier><identifier>DOI: 10.1158/1535-7163.MCT-21-0363</identifier><identifier>PMID: 34376575</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Biliary Tract Neoplasms - genetics ; Biliary Tract Neoplasms - metabolism ; Biliary Tract Neoplasms - pathology ; Exosomes - genetics ; Exosomes - metabolism ; Humans ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; RNA, Long Noncoding - genetics</subject><ispartof>Molecular cancer therapeutics, 2021-10, Vol.20 (10), p.1777-1788</ispartof><rights>2021 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e3e80795e33e8ab1a1f8be7c138979d77c29b6c5b539f8bcc5eadb3a61ca79973</citedby><cites>FETCH-LOGICAL-c356t-e3e80795e33e8ab1a1f8be7c138979d77c29b6c5b539f8bcc5eadb3a61ca79973</cites><orcidid>0000-0002-5637-121X ; 0000-0003-2720-0005 ; 0000-0003-2936-9509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34376575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Wangyang</creatorcontrib><creatorcontrib>Ji, Daolin</creatorcontrib><creatorcontrib>Zhou, Yongxu</creatorcontrib><creatorcontrib>Yu, Liang</creatorcontrib><creatorcontrib>Huang, Peng</creatorcontrib><creatorcontrib>Zheng, Yuling</creatorcontrib><creatorcontrib>Meng, Nanfeng</creatorcontrib><creatorcontrib>Wang, Hang</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Huang, ZiYue</creatorcontrib><creatorcontrib>Chen, Wangming</creatorcontrib><creatorcontrib>Yam, Judy W P</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Cui, Yunfu</creatorcontrib><title>Exosomal Noncoding RNAs in Hepatobiliary Cancer: A Rising Star</title><title>Molecular cancer therapeutics</title><addtitle>Mol Cancer Ther</addtitle><description>Hepatobiliary cancers are a heterogeneous group of malignancies with a dismal prognosis. Despite intensive research efforts focused on these tumors, methods for early diagnosis and effective targeted therapies are still lacking. Exosomes, released by most cells, exist in all kinds of body fluids and play an important role in cell-to-cell communication. They are small membranous vesicles containing biological molecules, such as noncoding RNAs (ncRNA), which are not translated into proteins, but they exert effects on the regulation of gene transcription and translation. There is growing evidence for the essential roles of ncRNAs in exosomes in both physiologic and pathologic conditions of hepatobiliary cancers. They have been identified as sensitive diagnostic biomarkers as well as potential therapeutic targets. The present review discusses recent findings in the cross-talk between hepatobiliary cancers cells and the surrounding cells of the microenvironment and discuss their potential clinical usage.</description><subject>Animals</subject><subject>Biliary Tract Neoplasms - genetics</subject><subject>Biliary Tract Neoplasms - metabolism</subject><subject>Biliary Tract Neoplasms - pathology</subject><subject>Exosomes - genetics</subject><subject>Exosomes - metabolism</subject><subject>Humans</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>RNA, Long Noncoding - genetics</subject><issn>1535-7163</issn><issn>1538-8514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFPwzAMhSMEYmPwE0A9cumomzlpOCBN1WBIY0hjnKMkzVBQ24ymk8a_p2WDk5_s92z5I-QakjEAZneAFGMOjI5f8nWcQpxQRk_IsOtncYYwOf3VB8-AXITwmSSQiRTOyYBOKGfIcUgeZnsffKXKaOlr4wtXf0Sr5TREro7mdqtar13pVPMd5ao2trmPptHKhd721qrmkpxtVBns1bGOyPvjbJ3P48Xr03M-XcSGImtjS22WcIGWdkJpULDJtOUGaCa4KDg3qdDMoEYquokxaFWhqWJgFBeC0xG5PezdNv5rZ0MrKxeMLUtVW78LMkWWpAKR9VY8WE3jQ2jsRm4bV3UfSEhkj072WGSPRXboZAqyR9flbo4ndrqyxX_qjxX9AXHSaQM</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Zheng, Wangyang</creator><creator>Ji, Daolin</creator><creator>Zhou, Yongxu</creator><creator>Yu, Liang</creator><creator>Huang, Peng</creator><creator>Zheng, Yuling</creator><creator>Meng, Nanfeng</creator><creator>Wang, Hang</creator><creator>Bai, Xue</creator><creator>Huang, ZiYue</creator><creator>Chen, Wangming</creator><creator>Yam, Judy W P</creator><creator>Xu, Yi</creator><creator>Cui, Yunfu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5637-121X</orcidid><orcidid>https://orcid.org/0000-0003-2720-0005</orcidid><orcidid>https://orcid.org/0000-0003-2936-9509</orcidid></search><sort><creationdate>202110</creationdate><title>Exosomal Noncoding RNAs in Hepatobiliary Cancer: A Rising Star</title><author>Zheng, Wangyang ; Ji, Daolin ; Zhou, Yongxu ; Yu, Liang ; Huang, Peng ; Zheng, Yuling ; Meng, Nanfeng ; Wang, Hang ; Bai, Xue ; Huang, ZiYue ; Chen, Wangming ; Yam, Judy W P ; Xu, Yi ; Cui, Yunfu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e3e80795e33e8ab1a1f8be7c138979d77c29b6c5b539f8bcc5eadb3a61ca79973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biliary Tract Neoplasms - genetics</topic><topic>Biliary Tract Neoplasms - metabolism</topic><topic>Biliary Tract Neoplasms - pathology</topic><topic>Exosomes - genetics</topic><topic>Exosomes - metabolism</topic><topic>Humans</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>RNA, Long Noncoding - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Wangyang</creatorcontrib><creatorcontrib>Ji, Daolin</creatorcontrib><creatorcontrib>Zhou, Yongxu</creatorcontrib><creatorcontrib>Yu, Liang</creatorcontrib><creatorcontrib>Huang, Peng</creatorcontrib><creatorcontrib>Zheng, Yuling</creatorcontrib><creatorcontrib>Meng, Nanfeng</creatorcontrib><creatorcontrib>Wang, Hang</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Huang, ZiYue</creatorcontrib><creatorcontrib>Chen, Wangming</creatorcontrib><creatorcontrib>Yam, Judy W P</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Cui, Yunfu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular cancer therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Wangyang</au><au>Ji, Daolin</au><au>Zhou, Yongxu</au><au>Yu, Liang</au><au>Huang, Peng</au><au>Zheng, Yuling</au><au>Meng, Nanfeng</au><au>Wang, Hang</au><au>Bai, Xue</au><au>Huang, ZiYue</au><au>Chen, Wangming</au><au>Yam, Judy W P</au><au>Xu, Yi</au><au>Cui, Yunfu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exosomal Noncoding RNAs in Hepatobiliary Cancer: A Rising Star</atitle><jtitle>Molecular cancer therapeutics</jtitle><addtitle>Mol Cancer Ther</addtitle><date>2021-10</date><risdate>2021</risdate><volume>20</volume><issue>10</issue><spage>1777</spage><epage>1788</epage><pages>1777-1788</pages><issn>1535-7163</issn><eissn>1538-8514</eissn><abstract>Hepatobiliary cancers are a heterogeneous group of malignancies with a dismal prognosis. 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| subjects | Animals Biliary Tract Neoplasms - genetics Biliary Tract Neoplasms - metabolism Biliary Tract Neoplasms - pathology Exosomes - genetics Exosomes - metabolism Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology RNA, Long Noncoding - genetics |
| title | Exosomal Noncoding RNAs in Hepatobiliary Cancer: A Rising Star |
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