Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model
Background The increase in fibronectin type-III domain-containing protein 5 (FNDC5), myonectin, and glucose transporter 4 (GLUT4) leads to a decrease in diabetes; meanwhile, exercise training can affect these factors. The result regarding the comparison between the effect of high-intensity interval...
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| Veröffentlicht in: | Molecular biology reports 2021-08, Vol.48 (8), p.6123-6129 |
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| creator | Rahmati-Ahmadabad, Saleh Rostamkhani, Fatemeh Meftahi, Gholam Hossein Shirvani, Hossein |
| description | Background
The increase in fibronectin type-III domain-containing protein 5 (FNDC5), myonectin, and glucose transporter 4 (GLUT4) leads to a decrease in diabetes; meanwhile, exercise training can affect these factors. The result regarding the comparison between the effect of high-intensity interval training (HIIT) and that of moderate-intensity continuous training (MICT) is confusing. Thus, the present study investigated the comparative effects of HIIT and MICT on soleus muscle FNDC5, myonectin, and GLUT4 gene expressions in the diabetic rat model.
Methods and results
Seventy-two male Wistar rats (weight 200 g ± 20) were randomly and equally assigned to six groups: control-healthy, MICT-healthy, HIIT-healthy, control-diabetes, MICT-diabetes, and HIIT-diabetes. At the first level, Streptozotocin (STZ) was utilized to induce diabetes in rats (at a dose of 55 mg/kg). After that, the training groups performed HIIT and MICT programs on the rodent treadmill for 6 weeks (five-session/week). Twenty-four hours after the last intervention, soleus muscle was removed, and sent to a research facility for future examinations. HIIT and MICT increased the muscle FNDC5, myonectin, and GLUT4 gene expression compared to the control group (P 0.05), while the MICT program induced a greater increase in the myonec ztin and GLUT4 compared to the HIIT program (P |
| doi_str_mv | 10.1007/s11033-021-06633-1 |
| format | Article |
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The increase in fibronectin type-III domain-containing protein 5 (FNDC5), myonectin, and glucose transporter 4 (GLUT4) leads to a decrease in diabetes; meanwhile, exercise training can affect these factors. The result regarding the comparison between the effect of high-intensity interval training (HIIT) and that of moderate-intensity continuous training (MICT) is confusing. Thus, the present study investigated the comparative effects of HIIT and MICT on soleus muscle FNDC5, myonectin, and GLUT4 gene expressions in the diabetic rat model.
Methods and results
Seventy-two male Wistar rats (weight 200 g ± 20) were randomly and equally assigned to six groups: control-healthy, MICT-healthy, HIIT-healthy, control-diabetes, MICT-diabetes, and HIIT-diabetes. At the first level, Streptozotocin (STZ) was utilized to induce diabetes in rats (at a dose of 55 mg/kg). After that, the training groups performed HIIT and MICT programs on the rodent treadmill for 6 weeks (five-session/week). Twenty-four hours after the last intervention, soleus muscle was removed, and sent to a research facility for future examinations. HIIT and MICT increased the muscle FNDC5, myonectin, and GLUT4 gene expression compared to the control group (P < 0.05). The type of training had no significant effect on the FNDC5 (P > 0.05), while the MICT program induced a greater increase in the myonec ztin and GLUT4 compared to the HIIT program (P < 0.05). Meanwhile, a positive relationship between all variables was observed.
Conclusions
Exercise training has a beneficial effect on diabetes conditions via the effect of FNDC5, myonectin, and GLUT4. Due to the correlation between myonectin and GLUT4 shown in the present study, physical activity may alter myonectin through its effect on GLUT requiring further investigation by subsequent studies.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-021-06633-1</identifier><identifier>PMID: 34374894</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Animal models ; Animals ; Biomedical and Life Sciences ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - genetics ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - therapy ; Exercise ; Fibronectin ; Fibronectins - metabolism ; Fitness training programs ; Gene expression ; Gene Expression - genetics ; Gene Expression Regulation - genetics ; Glucose transporter ; Glucose Transporter Type 4 - metabolism ; GLUT4 gene ; High-Intensity Interval Training - methods ; Histology ; Interval training ; Life Sciences ; Male ; Membrane Proteins - metabolism ; Morphology ; Original Article ; Physical activity ; Physical Conditioning, Animal - methods ; Physical fitness ; Physical training ; Rats ; Rats, Wistar ; Rodents ; Soleus muscle ; Streptozocin ; Streptozocin - pharmacology</subject><ispartof>Molecular biology reports, 2021-08, Vol.48 (8), p.6123-6129</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a683aff7e4558a6fc9716f6335b4a9c8029029be1260d0a8bc8cc03b9a2162023</citedby><cites>FETCH-LOGICAL-c375t-a683aff7e4558a6fc9716f6335b4a9c8029029be1260d0a8bc8cc03b9a2162023</cites><orcidid>0000-0002-9465-0199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-021-06633-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-021-06633-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34374894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahmati-Ahmadabad, Saleh</creatorcontrib><creatorcontrib>Rostamkhani, Fatemeh</creatorcontrib><creatorcontrib>Meftahi, Gholam Hossein</creatorcontrib><creatorcontrib>Shirvani, Hossein</creatorcontrib><title>Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Background
The increase in fibronectin type-III domain-containing protein 5 (FNDC5), myonectin, and glucose transporter 4 (GLUT4) leads to a decrease in diabetes; meanwhile, exercise training can affect these factors. The result regarding the comparison between the effect of high-intensity interval training (HIIT) and that of moderate-intensity continuous training (MICT) is confusing. Thus, the present study investigated the comparative effects of HIIT and MICT on soleus muscle FNDC5, myonectin, and GLUT4 gene expressions in the diabetic rat model.
Methods and results
Seventy-two male Wistar rats (weight 200 g ± 20) were randomly and equally assigned to six groups: control-healthy, MICT-healthy, HIIT-healthy, control-diabetes, MICT-diabetes, and HIIT-diabetes. At the first level, Streptozotocin (STZ) was utilized to induce diabetes in rats (at a dose of 55 mg/kg). After that, the training groups performed HIIT and MICT programs on the rodent treadmill for 6 weeks (five-session/week). Twenty-four hours after the last intervention, soleus muscle was removed, and sent to a research facility for future examinations. HIIT and MICT increased the muscle FNDC5, myonectin, and GLUT4 gene expression compared to the control group (P < 0.05). The type of training had no significant effect on the FNDC5 (P > 0.05), while the MICT program induced a greater increase in the myonec ztin and GLUT4 compared to the HIIT program (P < 0.05). Meanwhile, a positive relationship between all variables was observed.
Conclusions
Exercise training has a beneficial effect on diabetes conditions via the effect of FNDC5, myonectin, and GLUT4. Due to the correlation between myonectin and GLUT4 shown in the present study, physical activity may alter myonectin through its effect on GLUT requiring further investigation by subsequent studies.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - genetics</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Exercise</subject><subject>Fibronectin</subject><subject>Fibronectins - metabolism</subject><subject>Fitness training programs</subject><subject>Gene expression</subject><subject>Gene Expression - genetics</subject><subject>Gene Expression Regulation - genetics</subject><subject>Glucose transporter</subject><subject>Glucose Transporter Type 4 - metabolism</subject><subject>GLUT4 gene</subject><subject>High-Intensity Interval Training - methods</subject><subject>Histology</subject><subject>Interval training</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Membrane Proteins - metabolism</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Physical activity</subject><subject>Physical Conditioning, Animal - methods</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Soleus muscle</subject><subject>Streptozocin</subject><subject>Streptozocin - pharmacology</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk2L1TAUhuugONfRP-BCAm5cWE2atGndycWPCwNudF3S9OTeDG1Sk3Sw_97T6R1HXAiBHJLnvOeDN8teMvqOUSrfR8Yo5zktWE6rCiN2ke1YKXkuGlk_znaUU5aLumSX2bMYbyilgsnyaXbJBZeibsTu0cXej5MKKtlbIGAM6BSJN-Rkj6fcugQu2rSQNQq3aiApKOusOxLlejL6HjAV_gK1d8m62c_xAfWORD8APo1z1AMQY7vgHZayjqRlAnI4HEjvR-TzVeCcNwWfAJHyLRmXe36texxm7SOsFVycfMDeNh1BjuBwjl9TgBitd_EDUSSmuV_WLtIJSG9VB8lqgo3fDTA8z54YNUR4cb6vsh-fP33ff82vv3057D9e55rLMuWqqrkyRoIoy1pVRjeSVQbXXnZCNbqmRYOnA1ZUtKeq7nStNeVdowpWFbTgV9mbTRfn-jlDTO1oo4ZhUA5wX21RVpRWnNEa0df_oDd-Dg67Q0pKKUrJVqrYKB18jAFMOwU7qrC0jLarQ9rNIS06pL1zSMsw6dVZeu5G6P-k3FsCAb4BEb_cEcJD7f_I_gaYKMxo</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Rahmati-Ahmadabad, Saleh</creator><creator>Rostamkhani, Fatemeh</creator><creator>Meftahi, Gholam Hossein</creator><creator>Shirvani, Hossein</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9465-0199</orcidid></search><sort><creationdate>20210801</creationdate><title>Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model</title><author>Rahmati-Ahmadabad, Saleh ; Rostamkhani, Fatemeh ; Meftahi, Gholam Hossein ; Shirvani, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a683aff7e4558a6fc9716f6335b4a9c8029029be1260d0a8bc8cc03b9a2162023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - genetics</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Exercise</topic><topic>Fibronectin</topic><topic>Fibronectins - metabolism</topic><topic>Fitness training programs</topic><topic>Gene expression</topic><topic>Gene Expression - genetics</topic><topic>Gene Expression Regulation - genetics</topic><topic>Glucose transporter</topic><topic>Glucose Transporter Type 4 - metabolism</topic><topic>GLUT4 gene</topic><topic>High-Intensity Interval Training - methods</topic><topic>Histology</topic><topic>Interval training</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Membrane Proteins - metabolism</topic><topic>Morphology</topic><topic>Original Article</topic><topic>Physical activity</topic><topic>Physical Conditioning, Animal - methods</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Soleus muscle</topic><topic>Streptozocin</topic><topic>Streptozocin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahmati-Ahmadabad, Saleh</creatorcontrib><creatorcontrib>Rostamkhani, Fatemeh</creatorcontrib><creatorcontrib>Meftahi, Gholam Hossein</creatorcontrib><creatorcontrib>Shirvani, Hossein</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahmati-Ahmadabad, Saleh</au><au>Rostamkhani, Fatemeh</au><au>Meftahi, Gholam Hossein</au><au>Shirvani, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>48</volume><issue>8</issue><spage>6123</spage><epage>6129</epage><pages>6123-6129</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Background
The increase in fibronectin type-III domain-containing protein 5 (FNDC5), myonectin, and glucose transporter 4 (GLUT4) leads to a decrease in diabetes; meanwhile, exercise training can affect these factors. The result regarding the comparison between the effect of high-intensity interval training (HIIT) and that of moderate-intensity continuous training (MICT) is confusing. Thus, the present study investigated the comparative effects of HIIT and MICT on soleus muscle FNDC5, myonectin, and GLUT4 gene expressions in the diabetic rat model.
Methods and results
Seventy-two male Wistar rats (weight 200 g ± 20) were randomly and equally assigned to six groups: control-healthy, MICT-healthy, HIIT-healthy, control-diabetes, MICT-diabetes, and HIIT-diabetes. At the first level, Streptozotocin (STZ) was utilized to induce diabetes in rats (at a dose of 55 mg/kg). After that, the training groups performed HIIT and MICT programs on the rodent treadmill for 6 weeks (five-session/week). Twenty-four hours after the last intervention, soleus muscle was removed, and sent to a research facility for future examinations. HIIT and MICT increased the muscle FNDC5, myonectin, and GLUT4 gene expression compared to the control group (P < 0.05). The type of training had no significant effect on the FNDC5 (P > 0.05), while the MICT program induced a greater increase in the myonec ztin and GLUT4 compared to the HIIT program (P < 0.05). Meanwhile, a positive relationship between all variables was observed.
Conclusions
Exercise training has a beneficial effect on diabetes conditions via the effect of FNDC5, myonectin, and GLUT4. Due to the correlation between myonectin and GLUT4 shown in the present study, physical activity may alter myonectin through its effect on GLUT requiring further investigation by subsequent studies.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34374894</pmid><doi>10.1007/s11033-021-06633-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9465-0199</orcidid></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Animal models Animals Biomedical and Life Sciences Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - therapy Exercise Fibronectin Fibronectins - metabolism Fitness training programs Gene expression Gene Expression - genetics Gene Expression Regulation - genetics Glucose transporter Glucose Transporter Type 4 - metabolism GLUT4 gene High-Intensity Interval Training - methods Histology Interval training Life Sciences Male Membrane Proteins - metabolism Morphology Original Article Physical activity Physical Conditioning, Animal - methods Physical fitness Physical training Rats Rats, Wistar Rodents Soleus muscle Streptozocin Streptozocin - pharmacology |
| title | Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model |
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