Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left‐to‐Right Shunts in Patients With Right Ventricular Disease
Background Left‐to‐right (L‐R) shunts are characterized by a pathological connection between high‐ and low‐pressure systems, leading to a mixing of oxygen‐rich blood with low oxygenated blood. They are typically diagnosed by phase‐contrast cardiac magnetic resonance imaging (MRI) which requires exte...
Gespeichert in:
| Veröffentlicht in: | Journal of magnetic resonance imaging 2022-05, Vol.55 (5), p.1452-1458 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1458 |
|---|---|
| container_issue | 5 |
| container_start_page | 1452 |
| container_title | Journal of magnetic resonance imaging |
| container_volume | 55 |
| creator | Emrich, Tilman Bordonaro, Veronica Schoepf, U. Joseph Petrescu, Aniela Young, Gabrielle Halfmann, Moritz Schoeler, Theresia Decker, Josua Abidoye, Ibukun Emrich, Anna Lena Kreitner, Karl‐Friedrich Schmidt, Kai Helge Varga‐Szemes, Akos Secinaro, Aurelio |
| description | Background
Left‐to‐right (L‐R) shunts are characterized by a pathological connection between high‐ and low‐pressure systems, leading to a mixing of oxygen‐rich blood with low oxygenated blood. They are typically diagnosed by phase‐contrast cardiac magnetic resonance imaging (MRI) which requires extensive planning. T2 is sensitive to blood oxygenation and may be able to detect oxygenation differences between the left (LV) and right ventricles (RV) caused by L‐R shunts.
Purpose
To test the feasibility of routine T2 mapping to detect L‐R shunts.
Study Type
Retrospective.
Population
Patients with known L‐R shunts (N = 27), patients with RV disease without L‐R shunts (N = 21), and healthy volunteers (HV; N = 52).
Field Strength/Sequence
1.5 and 3 T/balanced steady‐state free‐precession (bSSFP) sequence (cine imaging), T2‐prepared bSSFP sequence (T2 mapping), and velocity sensitized gradient echo sequence (phase‐contrast MRI).
Assessment
Aortic (Qs) and pulmonary (Qp) flow was measured by phase‐contrast imaging, and the Qp/Qs ratio was calculated as a measure of shunt severity. T2 maps were used to measure T2 in the RV and LV and the RV/LV T2 ratio was calculated. Cine imaging was used to calculate RV end‐diastolic volume index (RV‐EDVi).
Statistical Tests
Wilcoxon test, paired t‐tests, Spearmen correlation coefficient, receiver operating curve (ROC) analysis. Significance level P 0.78 showed a sensitivity, specificity, and negative predictive value of 100%, 73.9%, and 100%, respectively, for the detection of L‐R shunts. The T2 ratio was strongly correlated with the severity of the shunt (r = 0.83).
Data Conclusion
RV/LV T2 ratio is an imaging biomarker that may be able to detect or rule‐out L‐R shunts. Such a diagnostic tool may prevent unnecessary phase‐contrast acquisitions in cases with RV dilatation of unknown etiology.
Level of Evidence
3
Technical Efficacy
Stage 2 |
| doi_str_mv | 10.1002/jmri.27881 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2560061863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2560061863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3931-1c21062eb5f0c36b5800e410fca048df66ea144103cc1590aa2063c8af81bce33</originalsourceid><addsrcrecordid>eNp9kc9u1DAQhyMEoqVw4QHQSFwQUtqxnXiTI13-LVpEtV3gGHmdcderrF3spKg3HoGH4Yl4EpymIMSBiz22P38z0i_LHjM8Zoj8ZLcP9pjPqordyQ5ZyXnOy0reTTWWImcVzg6yBzHuELGui_J-diAKMStYOTvMfqzsxbY_WZLp4RO5Plg9dCrAaed9C2fed7DmsFK99aAiKAcL5_xVOl8RzFVordLwfrWAcx2InHUXsB4_GR-g3xIs2iS1xurR4MAbGFv9_Pa992m5aQ7n28H1EayDs0TRWH-2_Ram17-nemkjqUgPs3tGdZEe3e5H2cfXr9bzt_nyw5vF_MUy16IWLGeaM5ScNqVBLeSmrBCpYGi0wqJqjZSkWJEuhNasrFEpjlLoSpmKbTQJcZQ9m7yXwX8ZKPbN3kZNXacc-SE2vJSIklVyRJ_-g-78EFyaruGyRFYLKWeJej5ROvgYA5nmMti9CtcNw2bMshmzbG6yTPCTW-Ww2VP7B_0dXgLYBHy1HV3_R9W8SwlN0l9EXKxU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2650193667</pqid></control><display><type>article</type><title>Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left‐to‐Right Shunts in Patients With Right Ventricular Disease</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Emrich, Tilman ; Bordonaro, Veronica ; Schoepf, U. Joseph ; Petrescu, Aniela ; Young, Gabrielle ; Halfmann, Moritz ; Schoeler, Theresia ; Decker, Josua ; Abidoye, Ibukun ; Emrich, Anna Lena ; Kreitner, Karl‐Friedrich ; Schmidt, Kai Helge ; Varga‐Szemes, Akos ; Secinaro, Aurelio</creator><creatorcontrib>Emrich, Tilman ; Bordonaro, Veronica ; Schoepf, U. Joseph ; Petrescu, Aniela ; Young, Gabrielle ; Halfmann, Moritz ; Schoeler, Theresia ; Decker, Josua ; Abidoye, Ibukun ; Emrich, Anna Lena ; Kreitner, Karl‐Friedrich ; Schmidt, Kai Helge ; Varga‐Szemes, Akos ; Secinaro, Aurelio</creatorcontrib><description>Background
Left‐to‐right (L‐R) shunts are characterized by a pathological connection between high‐ and low‐pressure systems, leading to a mixing of oxygen‐rich blood with low oxygenated blood. They are typically diagnosed by phase‐contrast cardiac magnetic resonance imaging (MRI) which requires extensive planning. T2 is sensitive to blood oxygenation and may be able to detect oxygenation differences between the left (LV) and right ventricles (RV) caused by L‐R shunts.
Purpose
To test the feasibility of routine T2 mapping to detect L‐R shunts.
Study Type
Retrospective.
Population
Patients with known L‐R shunts (N = 27), patients with RV disease without L‐R shunts (N = 21), and healthy volunteers (HV; N = 52).
Field Strength/Sequence
1.5 and 3 T/balanced steady‐state free‐precession (bSSFP) sequence (cine imaging), T2‐prepared bSSFP sequence (T2 mapping), and velocity sensitized gradient echo sequence (phase‐contrast MRI).
Assessment
Aortic (Qs) and pulmonary (Qp) flow was measured by phase‐contrast imaging, and the Qp/Qs ratio was calculated as a measure of shunt severity. T2 maps were used to measure T2 in the RV and LV and the RV/LV T2 ratio was calculated. Cine imaging was used to calculate RV end‐diastolic volume index (RV‐EDVi).
Statistical Tests
Wilcoxon test, paired t‐tests, Spearmen correlation coefficient, receiver operating curve (ROC) analysis. Significance level P < 0.05.
Results
The Qp/Qs and T2 ratios in L‐R shunt patients (1.84 ± 0.84 and 0.89 ± 0.07) were significantly higher compared to those in patients with RV disease (1.01 ± 0.03 and 0.72 ± 0.10) and in HV (1.04 ± 0.04 and 0.71 ± 0.09). A T2 ratio of >0.78 showed a sensitivity, specificity, and negative predictive value of 100%, 73.9%, and 100%, respectively, for the detection of L‐R shunts. The T2 ratio was strongly correlated with the severity of the shunt (r = 0.83).
Data Conclusion
RV/LV T2 ratio is an imaging biomarker that may be able to detect or rule‐out L‐R shunts. Such a diagnostic tool may prevent unnecessary phase‐contrast acquisitions in cases with RV dilatation of unknown etiology.
Level of Evidence
3
Technical Efficacy
Stage 2</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.27881</identifier><identifier>PMID: 34374157</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aorta ; Biomarkers ; Blood ; congenital ; Correlation coefficient ; Correlation coefficients ; Etiology ; Field strength ; Heart ; heart defects ; heart ventricles ; Heart Ventricles - diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Mapping ; Mathematical analysis ; Medical imaging ; Oxygenation ; Population studies ; Retrospective Studies ; Shunts ; Statistical analysis ; Statistical tests ; Ventricle</subject><ispartof>Journal of magnetic resonance imaging, 2022-05, Vol.55 (5), p.1452-1458</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2021 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3931-1c21062eb5f0c36b5800e410fca048df66ea144103cc1590aa2063c8af81bce33</citedby><cites>FETCH-LOGICAL-c3931-1c21062eb5f0c36b5800e410fca048df66ea144103cc1590aa2063c8af81bce33</cites><orcidid>0000-0003-4156-7727 ; 0000-0002-2781-7462 ; 0000-0002-6164-5641</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.27881$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.27881$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34374157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emrich, Tilman</creatorcontrib><creatorcontrib>Bordonaro, Veronica</creatorcontrib><creatorcontrib>Schoepf, U. Joseph</creatorcontrib><creatorcontrib>Petrescu, Aniela</creatorcontrib><creatorcontrib>Young, Gabrielle</creatorcontrib><creatorcontrib>Halfmann, Moritz</creatorcontrib><creatorcontrib>Schoeler, Theresia</creatorcontrib><creatorcontrib>Decker, Josua</creatorcontrib><creatorcontrib>Abidoye, Ibukun</creatorcontrib><creatorcontrib>Emrich, Anna Lena</creatorcontrib><creatorcontrib>Kreitner, Karl‐Friedrich</creatorcontrib><creatorcontrib>Schmidt, Kai Helge</creatorcontrib><creatorcontrib>Varga‐Szemes, Akos</creatorcontrib><creatorcontrib>Secinaro, Aurelio</creatorcontrib><title>Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left‐to‐Right Shunts in Patients With Right Ventricular Disease</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Left‐to‐right (L‐R) shunts are characterized by a pathological connection between high‐ and low‐pressure systems, leading to a mixing of oxygen‐rich blood with low oxygenated blood. They are typically diagnosed by phase‐contrast cardiac magnetic resonance imaging (MRI) which requires extensive planning. T2 is sensitive to blood oxygenation and may be able to detect oxygenation differences between the left (LV) and right ventricles (RV) caused by L‐R shunts.
Purpose
To test the feasibility of routine T2 mapping to detect L‐R shunts.
Study Type
Retrospective.
Population
Patients with known L‐R shunts (N = 27), patients with RV disease without L‐R shunts (N = 21), and healthy volunteers (HV; N = 52).
Field Strength/Sequence
1.5 and 3 T/balanced steady‐state free‐precession (bSSFP) sequence (cine imaging), T2‐prepared bSSFP sequence (T2 mapping), and velocity sensitized gradient echo sequence (phase‐contrast MRI).
Assessment
Aortic (Qs) and pulmonary (Qp) flow was measured by phase‐contrast imaging, and the Qp/Qs ratio was calculated as a measure of shunt severity. T2 maps were used to measure T2 in the RV and LV and the RV/LV T2 ratio was calculated. Cine imaging was used to calculate RV end‐diastolic volume index (RV‐EDVi).
Statistical Tests
Wilcoxon test, paired t‐tests, Spearmen correlation coefficient, receiver operating curve (ROC) analysis. Significance level P < 0.05.
Results
The Qp/Qs and T2 ratios in L‐R shunt patients (1.84 ± 0.84 and 0.89 ± 0.07) were significantly higher compared to those in patients with RV disease (1.01 ± 0.03 and 0.72 ± 0.10) and in HV (1.04 ± 0.04 and 0.71 ± 0.09). A T2 ratio of >0.78 showed a sensitivity, specificity, and negative predictive value of 100%, 73.9%, and 100%, respectively, for the detection of L‐R shunts. The T2 ratio was strongly correlated with the severity of the shunt (r = 0.83).
Data Conclusion
RV/LV T2 ratio is an imaging biomarker that may be able to detect or rule‐out L‐R shunts. Such a diagnostic tool may prevent unnecessary phase‐contrast acquisitions in cases with RV dilatation of unknown etiology.
Level of Evidence
3
Technical Efficacy
Stage 2</description><subject>Aorta</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>congenital</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Etiology</subject><subject>Field strength</subject><subject>Heart</subject><subject>heart defects</subject><subject>heart ventricles</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mapping</subject><subject>Mathematical analysis</subject><subject>Medical imaging</subject><subject>Oxygenation</subject><subject>Population studies</subject><subject>Retrospective Studies</subject><subject>Shunts</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Ventricle</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhyMEoqVw4QHQSFwQUtqxnXiTI13-LVpEtV3gGHmdcderrF3spKg3HoGH4Yl4EpymIMSBiz22P38z0i_LHjM8Zoj8ZLcP9pjPqordyQ5ZyXnOy0reTTWWImcVzg6yBzHuELGui_J-diAKMStYOTvMfqzsxbY_WZLp4RO5Plg9dCrAaed9C2fed7DmsFK99aAiKAcL5_xVOl8RzFVordLwfrWAcx2InHUXsB4_GR-g3xIs2iS1xurR4MAbGFv9_Pa992m5aQ7n28H1EayDs0TRWH-2_Ram17-nemkjqUgPs3tGdZEe3e5H2cfXr9bzt_nyw5vF_MUy16IWLGeaM5ScNqVBLeSmrBCpYGi0wqJqjZSkWJEuhNasrFEpjlLoSpmKbTQJcZQ9m7yXwX8ZKPbN3kZNXacc-SE2vJSIklVyRJ_-g-78EFyaruGyRFYLKWeJej5ROvgYA5nmMti9CtcNw2bMshmzbG6yTPCTW-Ww2VP7B_0dXgLYBHy1HV3_R9W8SwlN0l9EXKxU</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Emrich, Tilman</creator><creator>Bordonaro, Veronica</creator><creator>Schoepf, U. Joseph</creator><creator>Petrescu, Aniela</creator><creator>Young, Gabrielle</creator><creator>Halfmann, Moritz</creator><creator>Schoeler, Theresia</creator><creator>Decker, Josua</creator><creator>Abidoye, Ibukun</creator><creator>Emrich, Anna Lena</creator><creator>Kreitner, Karl‐Friedrich</creator><creator>Schmidt, Kai Helge</creator><creator>Varga‐Szemes, Akos</creator><creator>Secinaro, Aurelio</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4156-7727</orcidid><orcidid>https://orcid.org/0000-0002-2781-7462</orcidid><orcidid>https://orcid.org/0000-0002-6164-5641</orcidid></search><sort><creationdate>202205</creationdate><title>Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left‐to‐Right Shunts in Patients With Right Ventricular Disease</title><author>Emrich, Tilman ; Bordonaro, Veronica ; Schoepf, U. Joseph ; Petrescu, Aniela ; Young, Gabrielle ; Halfmann, Moritz ; Schoeler, Theresia ; Decker, Josua ; Abidoye, Ibukun ; Emrich, Anna Lena ; Kreitner, Karl‐Friedrich ; Schmidt, Kai Helge ; Varga‐Szemes, Akos ; Secinaro, Aurelio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3931-1c21062eb5f0c36b5800e410fca048df66ea144103cc1590aa2063c8af81bce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aorta</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>congenital</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Etiology</topic><topic>Field strength</topic><topic>Heart</topic><topic>heart defects</topic><topic>heart ventricles</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Mapping</topic><topic>Mathematical analysis</topic><topic>Medical imaging</topic><topic>Oxygenation</topic><topic>Population studies</topic><topic>Retrospective Studies</topic><topic>Shunts</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emrich, Tilman</creatorcontrib><creatorcontrib>Bordonaro, Veronica</creatorcontrib><creatorcontrib>Schoepf, U. Joseph</creatorcontrib><creatorcontrib>Petrescu, Aniela</creatorcontrib><creatorcontrib>Young, Gabrielle</creatorcontrib><creatorcontrib>Halfmann, Moritz</creatorcontrib><creatorcontrib>Schoeler, Theresia</creatorcontrib><creatorcontrib>Decker, Josua</creatorcontrib><creatorcontrib>Abidoye, Ibukun</creatorcontrib><creatorcontrib>Emrich, Anna Lena</creatorcontrib><creatorcontrib>Kreitner, Karl‐Friedrich</creatorcontrib><creatorcontrib>Schmidt, Kai Helge</creatorcontrib><creatorcontrib>Varga‐Szemes, Akos</creatorcontrib><creatorcontrib>Secinaro, Aurelio</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emrich, Tilman</au><au>Bordonaro, Veronica</au><au>Schoepf, U. Joseph</au><au>Petrescu, Aniela</au><au>Young, Gabrielle</au><au>Halfmann, Moritz</au><au>Schoeler, Theresia</au><au>Decker, Josua</au><au>Abidoye, Ibukun</au><au>Emrich, Anna Lena</au><au>Kreitner, Karl‐Friedrich</au><au>Schmidt, Kai Helge</au><au>Varga‐Szemes, Akos</au><au>Secinaro, Aurelio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left‐to‐Right Shunts in Patients With Right Ventricular Disease</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2022-05</date><risdate>2022</risdate><volume>55</volume><issue>5</issue><spage>1452</spage><epage>1458</epage><pages>1452-1458</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Left‐to‐right (L‐R) shunts are characterized by a pathological connection between high‐ and low‐pressure systems, leading to a mixing of oxygen‐rich blood with low oxygenated blood. They are typically diagnosed by phase‐contrast cardiac magnetic resonance imaging (MRI) which requires extensive planning. T2 is sensitive to blood oxygenation and may be able to detect oxygenation differences between the left (LV) and right ventricles (RV) caused by L‐R shunts.
Purpose
To test the feasibility of routine T2 mapping to detect L‐R shunts.
Study Type
Retrospective.
Population
Patients with known L‐R shunts (N = 27), patients with RV disease without L‐R shunts (N = 21), and healthy volunteers (HV; N = 52).
Field Strength/Sequence
1.5 and 3 T/balanced steady‐state free‐precession (bSSFP) sequence (cine imaging), T2‐prepared bSSFP sequence (T2 mapping), and velocity sensitized gradient echo sequence (phase‐contrast MRI).
Assessment
Aortic (Qs) and pulmonary (Qp) flow was measured by phase‐contrast imaging, and the Qp/Qs ratio was calculated as a measure of shunt severity. T2 maps were used to measure T2 in the RV and LV and the RV/LV T2 ratio was calculated. Cine imaging was used to calculate RV end‐diastolic volume index (RV‐EDVi).
Statistical Tests
Wilcoxon test, paired t‐tests, Spearmen correlation coefficient, receiver operating curve (ROC) analysis. Significance level P < 0.05.
Results
The Qp/Qs and T2 ratios in L‐R shunt patients (1.84 ± 0.84 and 0.89 ± 0.07) were significantly higher compared to those in patients with RV disease (1.01 ± 0.03 and 0.72 ± 0.10) and in HV (1.04 ± 0.04 and 0.71 ± 0.09). A T2 ratio of >0.78 showed a sensitivity, specificity, and negative predictive value of 100%, 73.9%, and 100%, respectively, for the detection of L‐R shunts. The T2 ratio was strongly correlated with the severity of the shunt (r = 0.83).
Data Conclusion
RV/LV T2 ratio is an imaging biomarker that may be able to detect or rule‐out L‐R shunts. Such a diagnostic tool may prevent unnecessary phase‐contrast acquisitions in cases with RV dilatation of unknown etiology.
Level of Evidence
3
Technical Efficacy
Stage 2</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34374157</pmid><doi>10.1002/jmri.27881</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4156-7727</orcidid><orcidid>https://orcid.org/0000-0002-2781-7462</orcidid><orcidid>https://orcid.org/0000-0002-6164-5641</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-1807 |
| ispartof | Journal of magnetic resonance imaging, 2022-05, Vol.55 (5), p.1452-1458 |
| issn | 1053-1807 1522-2586 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2560061863 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aorta Biomarkers Blood congenital Correlation coefficient Correlation coefficients Etiology Field strength Heart heart defects heart ventricles Heart Ventricles - diagnostic imaging Humans Magnetic Resonance Imaging Mapping Mathematical analysis Medical imaging Oxygenation Population studies Retrospective Studies Shunts Statistical analysis Statistical tests Ventricle |
| title | Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left‐to‐Right Shunts in Patients With Right Ventricular Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T14%3A21%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Right/Left%20Ventricular%20Blood%20Pool%20T2%20Ratio%20as%20an%20Innovative%20Cardiac%20MRI%20Screening%20Tool%20for%20the%20Identification%20of%20Left%E2%80%90to%E2%80%90Right%20Shunts%20in%20Patients%20With%20Right%20Ventricular%20Disease&rft.jtitle=Journal%20of%20magnetic%20resonance%20imaging&rft.au=Emrich,%20Tilman&rft.date=2022-05&rft.volume=55&rft.issue=5&rft.spage=1452&rft.epage=1458&rft.pages=1452-1458&rft.issn=1053-1807&rft.eissn=1522-2586&rft_id=info:doi/10.1002/jmri.27881&rft_dat=%3Cproquest_cross%3E2560061863%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2650193667&rft_id=info:pmid/34374157&rfr_iscdi=true |