Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems

[Display omitted] Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial biofilms, disperse the microbial community and increase their susceptibility to antibiotics and immune cells. Challenges for the clinical translation of biofilm-dispersing enzymes involve th...

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Veröffentlicht in:	Advanced drug delivery reviews 2021-12, Vol.179, p.113916-113916, Article 113916
Hauptverfasser:	Thorn, Chelsea R., Howell, P. Lynne, Wozniak, Daniel J., Prestidge, Clive A., Thomas, Nicky
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Biofilms - growth & development Clinical development Drug delivery systems Drug Delivery Systems - methods Drug Stability Enzyme therapeutics Enzymes - administration & dosage Enzymes - pharmacology Extracellular Polymeric Substance Matrix - metabolism Glycoside hydrolases Humans Targeted delivery
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