Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems
[Display omitted] Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial biofilms, disperse the microbial community and increase their susceptibility to antibiotics and immune cells. Challenges for the clinical translation of biofilm-dispersing enzymes involve th...
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| Veröffentlicht in: | Advanced drug delivery reviews 2021-12, Vol.179, p.113916-113916, Article 113916 |
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| container_end_page | 113916 |
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| container_title | Advanced drug delivery reviews |
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| creator | Thorn, Chelsea R. Howell, P. Lynne Wozniak, Daniel J. Prestidge, Clive A. Thomas, Nicky |
| description | [Display omitted]
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial biofilms, disperse the microbial community and increase their susceptibility to antibiotics and immune cells. Challenges for the clinical translation of biofilm-dispersing enzymes involve their susceptibility to denaturation, degradation, and clearance upon administration in vivo. Drug delivery systems aim to overcome these limitations through encapsulation, stabilization and protection from the exterior environment, thereby maintaining the enzymatic activity. Smart drug delivery systems offer target specificity, releasing payloads at the site of infection while minimizing unnecessary systemic exposure. This review highlights critical advances of biofilm-dispersing enzymes as a novel therapeutic approach for biofilm-associated infections. We explore how smart, bio-responsive delivery systems overcome the limiting factors of biofilm-dispersing enzymes and summarize the key systems designed. This review will guide future developments, focusing on utilizing selective and specific therapies in a targeted fashion to meet the unmet therapeutic needs of biofilm infections. |
| doi_str_mv | 10.1016/j.addr.2021.113916 |
| format | Article |
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Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial biofilms, disperse the microbial community and increase their susceptibility to antibiotics and immune cells. Challenges for the clinical translation of biofilm-dispersing enzymes involve their susceptibility to denaturation, degradation, and clearance upon administration in vivo. Drug delivery systems aim to overcome these limitations through encapsulation, stabilization and protection from the exterior environment, thereby maintaining the enzymatic activity. Smart drug delivery systems offer target specificity, releasing payloads at the site of infection while minimizing unnecessary systemic exposure. This review highlights critical advances of biofilm-dispersing enzymes as a novel therapeutic approach for biofilm-associated infections. We explore how smart, bio-responsive delivery systems overcome the limiting factors of biofilm-dispersing enzymes and summarize the key systems designed. This review will guide future developments, focusing on utilizing selective and specific therapies in a targeted fashion to meet the unmet therapeutic needs of biofilm infections.</description><identifier>ISSN: 0169-409X</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2021.113916</identifier><identifier>PMID: 34371086</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacology ; Biofilms - growth & development ; Clinical development ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug Stability ; Enzyme therapeutics ; Enzymes - administration & dosage ; Enzymes - pharmacology ; Extracellular Polymeric Substance Matrix - metabolism ; Glycoside hydrolases ; Humans ; Targeted delivery</subject><ispartof>Advanced drug delivery reviews, 2021-12, Vol.179, p.113916-113916, Article 113916</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-498399194f309371fcbe81c48ccc6da493bf2d7e334072f94264d3f10311ab963</citedby><cites>FETCH-LOGICAL-c356t-498399194f309371fcbe81c48ccc6da493bf2d7e334072f94264d3f10311ab963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.addr.2021.113916$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34371086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thorn, Chelsea R.</creatorcontrib><creatorcontrib>Howell, P. Lynne</creatorcontrib><creatorcontrib>Wozniak, Daniel J.</creatorcontrib><creatorcontrib>Prestidge, Clive A.</creatorcontrib><creatorcontrib>Thomas, Nicky</creatorcontrib><title>Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>[Display omitted]
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial biofilms, disperse the microbial community and increase their susceptibility to antibiotics and immune cells. Challenges for the clinical translation of biofilm-dispersing enzymes involve their susceptibility to denaturation, degradation, and clearance upon administration in vivo. Drug delivery systems aim to overcome these limitations through encapsulation, stabilization and protection from the exterior environment, thereby maintaining the enzymatic activity. Smart drug delivery systems offer target specificity, releasing payloads at the site of infection while minimizing unnecessary systemic exposure. This review highlights critical advances of biofilm-dispersing enzymes as a novel therapeutic approach for biofilm-associated infections. We explore how smart, bio-responsive delivery systems overcome the limiting factors of biofilm-dispersing enzymes and summarize the key systems designed. 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Lynne</creatorcontrib><creatorcontrib>Wozniak, Daniel J.</creatorcontrib><creatorcontrib>Prestidge, Clive A.</creatorcontrib><creatorcontrib>Thomas, Nicky</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thorn, Chelsea R.</au><au>Howell, P. Lynne</au><au>Wozniak, Daniel J.</au><au>Prestidge, Clive A.</au><au>Thomas, Nicky</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2021-12</date><risdate>2021</risdate><volume>179</volume><spage>113916</spage><epage>113916</epage><pages>113916-113916</pages><artnum>113916</artnum><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>[Display omitted]
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial biofilms, disperse the microbial community and increase their susceptibility to antibiotics and immune cells. Challenges for the clinical translation of biofilm-dispersing enzymes involve their susceptibility to denaturation, degradation, and clearance upon administration in vivo. Drug delivery systems aim to overcome these limitations through encapsulation, stabilization and protection from the exterior environment, thereby maintaining the enzymatic activity. Smart drug delivery systems offer target specificity, releasing payloads at the site of infection while minimizing unnecessary systemic exposure. This review highlights critical advances of biofilm-dispersing enzymes as a novel therapeutic approach for biofilm-associated infections. We explore how smart, bio-responsive delivery systems overcome the limiting factors of biofilm-dispersing enzymes and summarize the key systems designed. This review will guide future developments, focusing on utilizing selective and specific therapies in a targeted fashion to meet the unmet therapeutic needs of biofilm infections.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34371086</pmid><doi>10.1016/j.addr.2021.113916</doi><tpages>1</tpages></addata></record> |
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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2021-12, Vol.179, p.113916-113916, Article 113916 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Biofilms - growth & development Clinical development Drug delivery systems Drug Delivery Systems - methods Drug Stability Enzyme therapeutics Enzymes - administration & dosage Enzymes - pharmacology Extracellular Polymeric Substance Matrix - metabolism Glycoside hydrolases Humans Targeted delivery |
| title | Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems |
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