Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder
Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among peo...
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| Veröffentlicht in: | Journal of substance abuse treatment 2021-12, Vol.131, p.108558-108558, Article 108558 |
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| container_title | Journal of substance abuse treatment |
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| creator | Rezapour, Tara Hatami, Javad Farhoudian, Ali Noroozi, Alireza Daneshmand, Reza Sofuoglu, Mehmet Baldacchino, Alex Ekhtiari, Hamed |
| description | Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among people with opioid use disorder (OUD).
The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors.
Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P |
| doi_str_mv | 10.1016/j.jsat.2021.108558 |
| format | Article |
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The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors.
Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P < 0.001). The linear mixed model showed that scores on auditory verbal learning test and group intervention predicted the number of positive urine tests during a 3-month follow-up.
Working memory and inhibitory control, as well as receiving cognitive rehabilitation, could be potentially considered as predictors of treatment response for newly MMT admitted patients with OUD. Assessment of EF before treatment initiation may inform treatment providers about patient's cognitive deficits that may interfere with therapeutic interventions.
•Baseline executive function inform treatment providers about patient’s cognitive deficits that may interfere with treatment.•Working memory and inhibitory could potentially predict treatment response for newly MMT admitted patients with OUD.•Using supplementary remediation interventions targeting cognitive functions including EF could promote treatment outcomes.</description><identifier>ISSN: 0740-5472</identifier><identifier>EISSN: 1873-6483</identifier><identifier>DOI: 10.1016/j.jsat.2021.108558</identifier><identifier>PMID: 34366202</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Clinical outcomes ; Cognitive functioning ; Cognitive impairment ; Cognitive rehabilitation ; Court orders ; Executive function ; Intervention ; Length of stay ; Medical treatment ; Methadone ; Methadone maintenance treatment ; Morphine ; Narcotics ; Opioid use disorders ; Opioids ; Rehabilitation ; Relapse ; Response inhibition ; Retention ; Short term memory ; Stroop task ; Substance abuse treatment ; Substance use disorder ; Treatment response ; Urine tests ; Verbal learning</subject><ispartof>Journal of substance abuse treatment, 2021-12, Vol.131, p.108558-108558, Article 108558</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-db725fc7dea12ef8ee025cdf436035fa2cbec069fa12d362d92af047d6d129c93</citedby><cites>FETCH-LOGICAL-c428t-db725fc7dea12ef8ee025cdf436035fa2cbec069fa12d362d92af047d6d129c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jsat.2021.108558$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,30999,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34366202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezapour, Tara</creatorcontrib><creatorcontrib>Hatami, Javad</creatorcontrib><creatorcontrib>Farhoudian, Ali</creatorcontrib><creatorcontrib>Noroozi, Alireza</creatorcontrib><creatorcontrib>Daneshmand, Reza</creatorcontrib><creatorcontrib>Sofuoglu, Mehmet</creatorcontrib><creatorcontrib>Baldacchino, Alex</creatorcontrib><creatorcontrib>Ekhtiari, Hamed</creatorcontrib><title>Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder</title><title>Journal of substance abuse treatment</title><addtitle>J Subst Abuse Treat</addtitle><description>Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among people with opioid use disorder (OUD).
The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors.
Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P < 0.001). The linear mixed model showed that scores on auditory verbal learning test and group intervention predicted the number of positive urine tests during a 3-month follow-up.
Working memory and inhibitory control, as well as receiving cognitive rehabilitation, could be potentially considered as predictors of treatment response for newly MMT admitted patients with OUD. Assessment of EF before treatment initiation may inform treatment providers about patient's cognitive deficits that may interfere with therapeutic interventions.
•Baseline executive function inform treatment providers about patient’s cognitive deficits that may interfere with treatment.•Working memory and inhibitory could potentially predict treatment response for newly MMT admitted patients with OUD.•Using supplementary remediation interventions targeting cognitive functions including EF could promote treatment outcomes.</description><subject>Clinical outcomes</subject><subject>Cognitive functioning</subject><subject>Cognitive impairment</subject><subject>Cognitive rehabilitation</subject><subject>Court orders</subject><subject>Executive function</subject><subject>Intervention</subject><subject>Length of stay</subject><subject>Medical treatment</subject><subject>Methadone</subject><subject>Methadone maintenance treatment</subject><subject>Morphine</subject><subject>Narcotics</subject><subject>Opioid use disorders</subject><subject>Opioids</subject><subject>Rehabilitation</subject><subject>Relapse</subject><subject>Response inhibition</subject><subject>Retention</subject><subject>Short term memory</subject><subject>Stroop task</subject><subject>Substance abuse treatment</subject><subject>Substance use disorder</subject><subject>Treatment response</subject><subject>Urine tests</subject><subject>Verbal learning</subject><issn>0740-5472</issn><issn>1873-6483</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNp9kcGOFCEURYnROG3rD7gwJG7cVAtUQVUlbnSio8kkbnRNaHjMvEo1lED16Af439L26MKFKxLeuZfHvYQ852zHGVevp92UTdkJJni9GKQcHpANH_q2Ud3QPiQb1neskV0vLsiTnCfGmBBseEwu2q5Vquo25Oc7k2HGABS-g10LHoH6NdiCMWRqgqMJLOARww218SbgbyLBrdnjjMWcOGpNoEsCh7bQksCUA4RSobxUE6BYpxCXGegdllsaF4zo6FonDnNMDtJT8sibOcOz-3NLvn54_-XyY3P9-erT5dvrxnZiKI3b90J62zswXIAfAJiQ1vn6G9ZKb4Tdg2Vq9HXsWiXcKIxnXe-U42K0Y7slr86-S4rfVshFHzBbmGcTIK5ZCylH1cuOdxV9-Q86xTWFup0Wio-8Blkf3RJxpmyKOSfwekl4MOmH5kyfStKTPpWkTyXpc0lV9OLeet0fwP2V_GmlAm_OANQsjghJZ4sQbE24tlG0i_g__1-Lc6ZL</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Rezapour, Tara</creator><creator>Hatami, Javad</creator><creator>Farhoudian, Ali</creator><creator>Noroozi, Alireza</creator><creator>Daneshmand, Reza</creator><creator>Sofuoglu, Mehmet</creator><creator>Baldacchino, Alex</creator><creator>Ekhtiari, Hamed</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>K7.</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder</title><author>Rezapour, Tara ; Hatami, Javad ; Farhoudian, Ali ; Noroozi, Alireza ; Daneshmand, Reza ; Sofuoglu, Mehmet ; Baldacchino, Alex ; Ekhtiari, Hamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-db725fc7dea12ef8ee025cdf436035fa2cbec069fa12d362d92af047d6d129c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical outcomes</topic><topic>Cognitive functioning</topic><topic>Cognitive impairment</topic><topic>Cognitive rehabilitation</topic><topic>Court orders</topic><topic>Executive function</topic><topic>Intervention</topic><topic>Length of stay</topic><topic>Medical treatment</topic><topic>Methadone</topic><topic>Methadone maintenance treatment</topic><topic>Morphine</topic><topic>Narcotics</topic><topic>Opioid use disorders</topic><topic>Opioids</topic><topic>Rehabilitation</topic><topic>Relapse</topic><topic>Response inhibition</topic><topic>Retention</topic><topic>Short term memory</topic><topic>Stroop task</topic><topic>Substance abuse treatment</topic><topic>Substance use disorder</topic><topic>Treatment response</topic><topic>Urine tests</topic><topic>Verbal learning</topic><toplevel>online_resources</toplevel><creatorcontrib>Rezapour, Tara</creatorcontrib><creatorcontrib>Hatami, Javad</creatorcontrib><creatorcontrib>Farhoudian, Ali</creatorcontrib><creatorcontrib>Noroozi, Alireza</creatorcontrib><creatorcontrib>Daneshmand, Reza</creatorcontrib><creatorcontrib>Sofuoglu, Mehmet</creatorcontrib><creatorcontrib>Baldacchino, Alex</creatorcontrib><creatorcontrib>Ekhtiari, Hamed</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of substance abuse treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezapour, Tara</au><au>Hatami, Javad</au><au>Farhoudian, Ali</au><au>Noroozi, Alireza</au><au>Daneshmand, Reza</au><au>Sofuoglu, Mehmet</au><au>Baldacchino, Alex</au><au>Ekhtiari, Hamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder</atitle><jtitle>Journal of substance abuse treatment</jtitle><addtitle>J Subst Abuse Treat</addtitle><date>2021-12</date><risdate>2021</risdate><volume>131</volume><spage>108558</spage><epage>108558</epage><pages>108558-108558</pages><artnum>108558</artnum><issn>0740-5472</issn><eissn>1873-6483</eissn><abstract>Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among people with opioid use disorder (OUD).
The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors.
Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P < 0.001). The linear mixed model showed that scores on auditory verbal learning test and group intervention predicted the number of positive urine tests during a 3-month follow-up.
Working memory and inhibitory control, as well as receiving cognitive rehabilitation, could be potentially considered as predictors of treatment response for newly MMT admitted patients with OUD. Assessment of EF before treatment initiation may inform treatment providers about patient's cognitive deficits that may interfere with therapeutic interventions.
•Baseline executive function inform treatment providers about patient’s cognitive deficits that may interfere with treatment.•Working memory and inhibitory could potentially predict treatment response for newly MMT admitted patients with OUD.•Using supplementary remediation interventions targeting cognitive functions including EF could promote treatment outcomes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34366202</pmid><doi>10.1016/j.jsat.2021.108558</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Access via ScienceDirect (Elsevier) |
| subjects | Clinical outcomes Cognitive functioning Cognitive impairment Cognitive rehabilitation Court orders Executive function Intervention Length of stay Medical treatment Methadone Methadone maintenance treatment Morphine Narcotics Opioid use disorders Opioids Rehabilitation Relapse Response inhibition Retention Short term memory Stroop task Substance abuse treatment Substance use disorder Treatment response Urine tests Verbal learning |
| title | Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder |
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