Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes
Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D). Twenty-four participants (13 men; mean ± SD age 62 ± 8 ye...
Gespeichert in:
| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-09, Vol.31 (10), p.2969-2978 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2978 |
|---|---|
| container_issue | 10 |
| container_start_page | 2969 |
| container_title | Nutrition, metabolism, and cardiovascular diseases |
| container_volume | 31 |
| creator | Homer, Ashleigh R. Taylor, Frances C. Dempsey, Paddy C. Wheeler, Michael J. Sethi, Parneet Grace, Megan S. Green, Daniel J. Cohen, Neale D. Larsen, Robyn N. Kingwell, Bronwyn A. Owen, Neville Dunstan, David W. |
| description | Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D).
Twenty-four participants (13 men; mean ± SD age 62 ± 8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol·L−1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol·L−1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol·h·L−1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol·h·L−1, 95%CI 7.0, 12.9; P = 0.003). During the post-lunch period, compared to SIT (2.2 h, 95%CI 1.7, 2.6), time in hyperglycemia was significantly lower during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol·L−1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol·L−1, 95%CI 7.6, 8.7, P = 0.024).
With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D.
•22-hour glycemic control was assessed during and after a laboratory condition where sitting was interrupted with exercises.•Activities were performed once or twice per hour (6 or 3 min breaks respectively), and compared to uninterrupted sitting.•Following the lunch-time meal, glycemic control was significantly improved when sitting was interrupted once per hour.•When sitting was interrupted twice per hour, nocturnal glycemic control was improved when compared to uninterrupted sitting. |
| doi_str_mv | 10.1016/j.numecd.2021.07.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2559671529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0939475321003215</els_id><sourcerecordid>2559671529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-11987ef90ecc348f225725165d1a6c80a23e4fcab8d6004b5a6e045d6ba162753</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMoWC9v4CJLNzOeZCZz2QhSr1Bwo-uQZk7alGlSk7RQfBmfxSczUteuDodzvh_-j5ArBiUD1tysSrddox5KDpyV0JYA7IhMmOihqFreH5MJ9FVf1K2oTslZjCuAqoWqnpDPe2sMBnSJmoAfW3TaYqTeUKWT3SG1LmEI202y3kWaPI02JesWdKnydbAxLzpRzCk6ZdBRzr-_lnQx7jWurabauxT8mINo2m-Q8gypOSaMF-TEqDHi5d88J--PD2_T52L2-vQyvZsVuupEKhjruxZND6h1VXeGc9FywRoxMNXoDhSvsDZazbuhAajnQjUItRiauWINz5XPyfUhdxN8bhiTXNuocRyVQ7-NkgvRNy0TvM-v9eFVBx9jQCM3wa5V2EsG8te1XMmDa_nrWkIrs-uM3R4wzDV2FoOMWaPTONiQtcjB2_8DfgDazYvk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559671529</pqid></control><display><type>article</type><title>Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes</title><source>Elsevier ScienceDirect Journals</source><creator>Homer, Ashleigh R. ; Taylor, Frances C. ; Dempsey, Paddy C. ; Wheeler, Michael J. ; Sethi, Parneet ; Grace, Megan S. ; Green, Daniel J. ; Cohen, Neale D. ; Larsen, Robyn N. ; Kingwell, Bronwyn A. ; Owen, Neville ; Dunstan, David W.</creator><creatorcontrib>Homer, Ashleigh R. ; Taylor, Frances C. ; Dempsey, Paddy C. ; Wheeler, Michael J. ; Sethi, Parneet ; Grace, Megan S. ; Green, Daniel J. ; Cohen, Neale D. ; Larsen, Robyn N. ; Kingwell, Bronwyn A. ; Owen, Neville ; Dunstan, David W.</creatorcontrib><description>Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D).
Twenty-four participants (13 men; mean ± SD age 62 ± 8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol·L−1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol·L−1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol·h·L−1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol·h·L−1, 95%CI 7.0, 12.9; P = 0.003). During the post-lunch period, compared to SIT (2.2 h, 95%CI 1.7, 2.6), time in hyperglycemia was significantly lower during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol·L−1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol·L−1, 95%CI 7.6, 8.7, P = 0.024).
With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D.
•22-hour glycemic control was assessed during and after a laboratory condition where sitting was interrupted with exercises.•Activities were performed once or twice per hour (6 or 3 min breaks respectively), and compared to uninterrupted sitting.•Following the lunch-time meal, glycemic control was significantly improved when sitting was interrupted once per hour.•When sitting was interrupted twice per hour, nocturnal glycemic control was improved when compared to uninterrupted sitting.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2021.07.001</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Active breaks ; Glycemic control ; Nocturnal glucose ; Postprandial glucose ; Sedentary behaviour ; Type 2 diabetes</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2021-09, Vol.31 (10), p.2969-2978</ispartof><rights>2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-11987ef90ecc348f225725165d1a6c80a23e4fcab8d6004b5a6e045d6ba162753</citedby><cites>FETCH-LOGICAL-c385t-11987ef90ecc348f225725165d1a6c80a23e4fcab8d6004b5a6e045d6ba162753</cites><orcidid>0000-0002-7404-7069 ; 0000-0002-6801-3014 ; 0000-0003-2438-1541 ; 0000-0003-3226-2921 ; 0000-0002-2162-0458 ; 0000-0003-2629-9568 ; 0000-0002-4985-7211 ; 0000-0003-2784-4820</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475321003215$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Homer, Ashleigh R.</creatorcontrib><creatorcontrib>Taylor, Frances C.</creatorcontrib><creatorcontrib>Dempsey, Paddy C.</creatorcontrib><creatorcontrib>Wheeler, Michael J.</creatorcontrib><creatorcontrib>Sethi, Parneet</creatorcontrib><creatorcontrib>Grace, Megan S.</creatorcontrib><creatorcontrib>Green, Daniel J.</creatorcontrib><creatorcontrib>Cohen, Neale D.</creatorcontrib><creatorcontrib>Larsen, Robyn N.</creatorcontrib><creatorcontrib>Kingwell, Bronwyn A.</creatorcontrib><creatorcontrib>Owen, Neville</creatorcontrib><creatorcontrib>Dunstan, David W.</creatorcontrib><title>Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes</title><title>Nutrition, metabolism, and cardiovascular diseases</title><description>Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D).
Twenty-four participants (13 men; mean ± SD age 62 ± 8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol·L−1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol·L−1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol·h·L−1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol·h·L−1, 95%CI 7.0, 12.9; P = 0.003). During the post-lunch period, compared to SIT (2.2 h, 95%CI 1.7, 2.6), time in hyperglycemia was significantly lower during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol·L−1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol·L−1, 95%CI 7.6, 8.7, P = 0.024).
With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D.
•22-hour glycemic control was assessed during and after a laboratory condition where sitting was interrupted with exercises.•Activities were performed once or twice per hour (6 or 3 min breaks respectively), and compared to uninterrupted sitting.•Following the lunch-time meal, glycemic control was significantly improved when sitting was interrupted once per hour.•When sitting was interrupted twice per hour, nocturnal glycemic control was improved when compared to uninterrupted sitting.</description><subject>Active breaks</subject><subject>Glycemic control</subject><subject>Nocturnal glucose</subject><subject>Postprandial glucose</subject><subject>Sedentary behaviour</subject><subject>Type 2 diabetes</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMoWC9v4CJLNzOeZCZz2QhSr1Bwo-uQZk7alGlSk7RQfBmfxSczUteuDodzvh_-j5ArBiUD1tysSrddox5KDpyV0JYA7IhMmOihqFreH5MJ9FVf1K2oTslZjCuAqoWqnpDPe2sMBnSJmoAfW3TaYqTeUKWT3SG1LmEI202y3kWaPI02JesWdKnydbAxLzpRzCk6ZdBRzr-_lnQx7jWurabauxT8mINo2m-Q8gypOSaMF-TEqDHi5d88J--PD2_T52L2-vQyvZsVuupEKhjruxZND6h1VXeGc9FywRoxMNXoDhSvsDZazbuhAajnQjUItRiauWINz5XPyfUhdxN8bhiTXNuocRyVQ7-NkgvRNy0TvM-v9eFVBx9jQCM3wa5V2EsG8te1XMmDa_nrWkIrs-uM3R4wzDV2FoOMWaPTONiQtcjB2_8DfgDazYvk</recordid><startdate>20210922</startdate><enddate>20210922</enddate><creator>Homer, Ashleigh R.</creator><creator>Taylor, Frances C.</creator><creator>Dempsey, Paddy C.</creator><creator>Wheeler, Michael J.</creator><creator>Sethi, Parneet</creator><creator>Grace, Megan S.</creator><creator>Green, Daniel J.</creator><creator>Cohen, Neale D.</creator><creator>Larsen, Robyn N.</creator><creator>Kingwell, Bronwyn A.</creator><creator>Owen, Neville</creator><creator>Dunstan, David W.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7404-7069</orcidid><orcidid>https://orcid.org/0000-0002-6801-3014</orcidid><orcidid>https://orcid.org/0000-0003-2438-1541</orcidid><orcidid>https://orcid.org/0000-0003-3226-2921</orcidid><orcidid>https://orcid.org/0000-0002-2162-0458</orcidid><orcidid>https://orcid.org/0000-0003-2629-9568</orcidid><orcidid>https://orcid.org/0000-0002-4985-7211</orcidid><orcidid>https://orcid.org/0000-0003-2784-4820</orcidid></search><sort><creationdate>20210922</creationdate><title>Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes</title><author>Homer, Ashleigh R. ; Taylor, Frances C. ; Dempsey, Paddy C. ; Wheeler, Michael J. ; Sethi, Parneet ; Grace, Megan S. ; Green, Daniel J. ; Cohen, Neale D. ; Larsen, Robyn N. ; Kingwell, Bronwyn A. ; Owen, Neville ; Dunstan, David W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-11987ef90ecc348f225725165d1a6c80a23e4fcab8d6004b5a6e045d6ba162753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Active breaks</topic><topic>Glycemic control</topic><topic>Nocturnal glucose</topic><topic>Postprandial glucose</topic><topic>Sedentary behaviour</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Homer, Ashleigh R.</creatorcontrib><creatorcontrib>Taylor, Frances C.</creatorcontrib><creatorcontrib>Dempsey, Paddy C.</creatorcontrib><creatorcontrib>Wheeler, Michael J.</creatorcontrib><creatorcontrib>Sethi, Parneet</creatorcontrib><creatorcontrib>Grace, Megan S.</creatorcontrib><creatorcontrib>Green, Daniel J.</creatorcontrib><creatorcontrib>Cohen, Neale D.</creatorcontrib><creatorcontrib>Larsen, Robyn N.</creatorcontrib><creatorcontrib>Kingwell, Bronwyn A.</creatorcontrib><creatorcontrib>Owen, Neville</creatorcontrib><creatorcontrib>Dunstan, David W.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Homer, Ashleigh R.</au><au>Taylor, Frances C.</au><au>Dempsey, Paddy C.</au><au>Wheeler, Michael J.</au><au>Sethi, Parneet</au><au>Grace, Megan S.</au><au>Green, Daniel J.</au><au>Cohen, Neale D.</au><au>Larsen, Robyn N.</au><au>Kingwell, Bronwyn A.</au><au>Owen, Neville</au><au>Dunstan, David W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><date>2021-09-22</date><risdate>2021</risdate><volume>31</volume><issue>10</issue><spage>2969</spage><epage>2978</epage><pages>2969-2978</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Whether the frequency of interruptions to sitting time involving simple resistance activities (SRAs), compared to uninterrupted sitting, differentially affected 22 h glycemic control in adults with medication-controlled type 2 diabetes (T2D).
Twenty-four participants (13 men; mean ± SD age 62 ± 8 years) completed three 8 h laboratory conditions: SIT: uninterrupted sitting; SRA3: sitting interrupted with 3 min of SRAs every 30 min; and, SRA6: sitting interrupted with 6 min of SRAs every 60 min. Flash glucose monitors assessed glycemic control over a 22 h period. No differences were observed between conditions for overall 22 h glycemic control as measured by AUCtotal, mean glucose and time in hyperglycemia. During the 3.5 h post-lunch period, mean glucose was significantly lower during SRA6 (10.1 mmol·L−1, 95%CI 9.2, 11.0) compared to SIT (11.1 mmol·L−1, 95%CI 10.2, 12.0; P = 0.006). Post-lunch iAUCnet was significantly lower during SRA6 (6.2 mmol·h·L−1, 95%CI 3.3, 9.1) compared to SIT (9.9 mmol·h·L−1, 95%CI 7.0, 12.9; P = 0.003). During the post-lunch period, compared to SIT (2.2 h, 95%CI 1.7, 2.6), time in hyperglycemia was significantly lower during SRA6 (1.5 h, 95%CI 1.0, 1.9, P = 0.001). Nocturnal mean glucose was significantly lower following the SRA3 condition (7.6 mmol·L−1, 95%CI 7.1, 8.1) compared to SIT (8.1 mmol·L−1, 95%CI 7.6, 8.7, P = 0.024).
With standardized total activity time, less-frequent active interruptions to sitting may acutely improve glycemic control; while more-frequent interruptions may be beneficial for nocturnal glucose in those with medication-controlled T2D.
•22-hour glycemic control was assessed during and after a laboratory condition where sitting was interrupted with exercises.•Activities were performed once or twice per hour (6 or 3 min breaks respectively), and compared to uninterrupted sitting.•Following the lunch-time meal, glycemic control was significantly improved when sitting was interrupted once per hour.•When sitting was interrupted twice per hour, nocturnal glycemic control was improved when compared to uninterrupted sitting.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.numecd.2021.07.001</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7404-7069</orcidid><orcidid>https://orcid.org/0000-0002-6801-3014</orcidid><orcidid>https://orcid.org/0000-0003-2438-1541</orcidid><orcidid>https://orcid.org/0000-0003-3226-2921</orcidid><orcidid>https://orcid.org/0000-0002-2162-0458</orcidid><orcidid>https://orcid.org/0000-0003-2629-9568</orcidid><orcidid>https://orcid.org/0000-0002-4985-7211</orcidid><orcidid>https://orcid.org/0000-0003-2784-4820</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-4753 |
| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2021-09, Vol.31 (10), p.2969-2978 |
| issn | 0939-4753 1590-3729 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2559671529 |
| source | Elsevier ScienceDirect Journals |
| subjects | Active breaks Glycemic control Nocturnal glucose Postprandial glucose Sedentary behaviour Type 2 diabetes |
| title | Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T13%3A29%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20frequencies%20of%20active%20interruptions%20to%20sitting%20have%20distinct%20effects%20on%2022%C2%A0h%20glycemic%20control%20in%20type%202%20diabetes&rft.jtitle=Nutrition,%20metabolism,%20and%20cardiovascular%20diseases&rft.au=Homer,%20Ashleigh%20R.&rft.date=2021-09-22&rft.volume=31&rft.issue=10&rft.spage=2969&rft.epage=2978&rft.pages=2969-2978&rft.issn=0939-4753&rft.eissn=1590-3729&rft_id=info:doi/10.1016/j.numecd.2021.07.001&rft_dat=%3Cproquest_cross%3E2559671529%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2559671529&rft_id=info:pmid/&rft_els_id=S0939475321003215&rfr_iscdi=true |