Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media
In this work, an automated liquid-liquid microextraction procedure for the determination of sulfonamides (sulfamethoxazole, sulfamethazine and sulfapyridine) in urine samples using natural deep eutectic solvent is presented for the first time. The mechanism for extraction of sulfonamides was based o...
Gespeichert in:
| Veröffentlicht in: | Talanta (Oxford) 2021-11, Vol.234, p.122660-122660, Article 122660 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 122660 |
|---|---|
| container_issue | |
| container_start_page | 122660 |
| container_title | Talanta (Oxford) |
| container_volume | 234 |
| creator | Shakirova, Firuza Shishov, Andrey Bulatov, Andrey |
| description | In this work, an automated liquid-liquid microextraction procedure for the determination of sulfonamides (sulfamethoxazole, sulfamethazine and sulfapyridine) in urine samples using natural deep eutectic solvent is presented for the first time. The mechanism for extraction of sulfonamides was based on the formation of colored Schiff bases in the presence of vanillin, which acted as a derivatization reagent and precursor of natural deep eutectic solvent (an extractant). In this procedure, thymol was used as both media for Schiff bases formation and as a second precursor of the natural deep eutectic solvent. The formation of the Schiff bases was confirmed by mass spectrometry. A Lab-In-Syringe concept was applied for the automation of the microextraction procedure. The procedure involved mixing the sample and natural deep eutectic solvent into a syringe of a flow system, formation and microextraction of colored Schiff base followed by UV–Vis detection. Under optimal automated conditions the limits of detection, calculated from a blank test based on 3s (sigma) were 0.06, 0.1, and 0.06 mg L−1 for sulfapyridine, sulfamethoxazole and sulfamethazine. The proposed automated procedure permitted the routine determination of one drug (sulfamethoxazole, sulfamethazine or sulfapyridine) in urine samples to be achieved in less than 10 min.
[Display omitted]
•Microextraction of sulfonamides in natural deep eutectic solvent (NADES).•Schiff base formation of sulfonamides in NADES based on vanillin and thymol.•Automated NADES-based microextraction for sulfonamides determination in urine. |
| doi_str_mv | 10.1016/j.talanta.2021.122660 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2559671164</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0039914021005816</els_id><sourcerecordid>2559671164</sourcerecordid><originalsourceid>FETCH-LOGICAL-c272t-2a98c8f803340f29e111b4a0e94e0eb78fc394395bde9761df2ad6c200b6e64e3</originalsourceid><addsrcrecordid>eNqFkc1u3SAQhVHUSr1N-giVWHbj2wFsbFZRFPVPitRFmzXCMKhcGXMDOGofp29aEmff1YjROR86cwh5z-DIgMmPp2M1i1mrOXLg7Mg4lxIuyIFNo-jEMIpX5AAgVKdYD2_I21JOAMAFiAP5e7PVFE1FR5fwsAXX7YPGYHPC3zUbW0NaqVkddVgxx7Ca503ytGyLT6uJwWGhYaVbDivSYuJ5aYvZlIZtyh_2V_D--V2oTznugGZoqC2bpZHxTHGr2D6ztKTlEddKI7pgrshrb5aC717mJbn__Onn7dfu7vuXb7c3d53lI68dN2qyk59AiB48V8gYm3sDqHoEnMfJW6F6oYbZoRolc54bJy0HmCXKHsUl-bBzzzk9bFiqjqFYXNplMW1F82FQcmRM9k067NJ2olIyen3OIZr8RzPQT5Xok36pRD9VovdKmu9692HL8Rgw62IDrrbFzC25din8h_APriCb6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559671164</pqid></control><display><type>article</type><title>Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media</title><source>Access via ScienceDirect (Elsevier)</source><creator>Shakirova, Firuza ; Shishov, Andrey ; Bulatov, Andrey</creator><creatorcontrib>Shakirova, Firuza ; Shishov, Andrey ; Bulatov, Andrey</creatorcontrib><description>In this work, an automated liquid-liquid microextraction procedure for the determination of sulfonamides (sulfamethoxazole, sulfamethazine and sulfapyridine) in urine samples using natural deep eutectic solvent is presented for the first time. The mechanism for extraction of sulfonamides was based on the formation of colored Schiff bases in the presence of vanillin, which acted as a derivatization reagent and precursor of natural deep eutectic solvent (an extractant). In this procedure, thymol was used as both media for Schiff bases formation and as a second precursor of the natural deep eutectic solvent. The formation of the Schiff bases was confirmed by mass spectrometry. A Lab-In-Syringe concept was applied for the automation of the microextraction procedure. The procedure involved mixing the sample and natural deep eutectic solvent into a syringe of a flow system, formation and microextraction of colored Schiff base followed by UV–Vis detection. Under optimal automated conditions the limits of detection, calculated from a blank test based on 3s (sigma) were 0.06, 0.1, and 0.06 mg L−1 for sulfapyridine, sulfamethoxazole and sulfamethazine. The proposed automated procedure permitted the routine determination of one drug (sulfamethoxazole, sulfamethazine or sulfapyridine) in urine samples to be achieved in less than 10 min.
[Display omitted]
•Microextraction of sulfonamides in natural deep eutectic solvent (NADES).•Schiff base formation of sulfonamides in NADES based on vanillin and thymol.•Automated NADES-based microextraction for sulfonamides determination in urine.</description><identifier>ISSN: 0039-9140</identifier><identifier>EISSN: 1873-3573</identifier><identifier>DOI: 10.1016/j.talanta.2021.122660</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Lab-in-syringe ; Liquid-liquid microextraction ; Natural deep eutectic solvent ; Sulfonamides ; Urea</subject><ispartof>Talanta (Oxford), 2021-11, Vol.234, p.122660-122660, Article 122660</ispartof><rights>2021 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-2a98c8f803340f29e111b4a0e94e0eb78fc394395bde9761df2ad6c200b6e64e3</citedby><cites>FETCH-LOGICAL-c272t-2a98c8f803340f29e111b4a0e94e0eb78fc394395bde9761df2ad6c200b6e64e3</cites><orcidid>0000-0003-1018-9479</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.talanta.2021.122660$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996</link.rule.ids></links><search><creatorcontrib>Shakirova, Firuza</creatorcontrib><creatorcontrib>Shishov, Andrey</creatorcontrib><creatorcontrib>Bulatov, Andrey</creatorcontrib><title>Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media</title><title>Talanta (Oxford)</title><description>In this work, an automated liquid-liquid microextraction procedure for the determination of sulfonamides (sulfamethoxazole, sulfamethazine and sulfapyridine) in urine samples using natural deep eutectic solvent is presented for the first time. The mechanism for extraction of sulfonamides was based on the formation of colored Schiff bases in the presence of vanillin, which acted as a derivatization reagent and precursor of natural deep eutectic solvent (an extractant). In this procedure, thymol was used as both media for Schiff bases formation and as a second precursor of the natural deep eutectic solvent. The formation of the Schiff bases was confirmed by mass spectrometry. A Lab-In-Syringe concept was applied for the automation of the microextraction procedure. The procedure involved mixing the sample and natural deep eutectic solvent into a syringe of a flow system, formation and microextraction of colored Schiff base followed by UV–Vis detection. Under optimal automated conditions the limits of detection, calculated from a blank test based on 3s (sigma) were 0.06, 0.1, and 0.06 mg L−1 for sulfapyridine, sulfamethoxazole and sulfamethazine. The proposed automated procedure permitted the routine determination of one drug (sulfamethoxazole, sulfamethazine or sulfapyridine) in urine samples to be achieved in less than 10 min.
[Display omitted]
•Microextraction of sulfonamides in natural deep eutectic solvent (NADES).•Schiff base formation of sulfonamides in NADES based on vanillin and thymol.•Automated NADES-based microextraction for sulfonamides determination in urine.</description><subject>Lab-in-syringe</subject><subject>Liquid-liquid microextraction</subject><subject>Natural deep eutectic solvent</subject><subject>Sulfonamides</subject><subject>Urea</subject><issn>0039-9140</issn><issn>1873-3573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u3SAQhVHUSr1N-giVWHbj2wFsbFZRFPVPitRFmzXCMKhcGXMDOGofp29aEmff1YjROR86cwh5z-DIgMmPp2M1i1mrOXLg7Mg4lxIuyIFNo-jEMIpX5AAgVKdYD2_I21JOAMAFiAP5e7PVFE1FR5fwsAXX7YPGYHPC3zUbW0NaqVkddVgxx7Ca503ytGyLT6uJwWGhYaVbDivSYuJ5aYvZlIZtyh_2V_D--V2oTznugGZoqC2bpZHxTHGr2D6ztKTlEddKI7pgrshrb5aC717mJbn__Onn7dfu7vuXb7c3d53lI68dN2qyk59AiB48V8gYm3sDqHoEnMfJW6F6oYbZoRolc54bJy0HmCXKHsUl-bBzzzk9bFiqjqFYXNplMW1F82FQcmRM9k067NJ2olIyen3OIZr8RzPQT5Xok36pRD9VovdKmu9692HL8Rgw62IDrrbFzC25din8h_APriCb6Q</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Shakirova, Firuza</creator><creator>Shishov, Andrey</creator><creator>Bulatov, Andrey</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1018-9479</orcidid></search><sort><creationdate>20211101</creationdate><title>Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media</title><author>Shakirova, Firuza ; Shishov, Andrey ; Bulatov, Andrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-2a98c8f803340f29e111b4a0e94e0eb78fc394395bde9761df2ad6c200b6e64e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Lab-in-syringe</topic><topic>Liquid-liquid microextraction</topic><topic>Natural deep eutectic solvent</topic><topic>Sulfonamides</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shakirova, Firuza</creatorcontrib><creatorcontrib>Shishov, Andrey</creatorcontrib><creatorcontrib>Bulatov, Andrey</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Talanta (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shakirova, Firuza</au><au>Shishov, Andrey</au><au>Bulatov, Andrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media</atitle><jtitle>Talanta (Oxford)</jtitle><date>2021-11-01</date><risdate>2021</risdate><volume>234</volume><spage>122660</spage><epage>122660</epage><pages>122660-122660</pages><artnum>122660</artnum><issn>0039-9140</issn><eissn>1873-3573</eissn><abstract>In this work, an automated liquid-liquid microextraction procedure for the determination of sulfonamides (sulfamethoxazole, sulfamethazine and sulfapyridine) in urine samples using natural deep eutectic solvent is presented for the first time. The mechanism for extraction of sulfonamides was based on the formation of colored Schiff bases in the presence of vanillin, which acted as a derivatization reagent and precursor of natural deep eutectic solvent (an extractant). In this procedure, thymol was used as both media for Schiff bases formation and as a second precursor of the natural deep eutectic solvent. The formation of the Schiff bases was confirmed by mass spectrometry. A Lab-In-Syringe concept was applied for the automation of the microextraction procedure. The procedure involved mixing the sample and natural deep eutectic solvent into a syringe of a flow system, formation and microextraction of colored Schiff base followed by UV–Vis detection. Under optimal automated conditions the limits of detection, calculated from a blank test based on 3s (sigma) were 0.06, 0.1, and 0.06 mg L−1 for sulfapyridine, sulfamethoxazole and sulfamethazine. The proposed automated procedure permitted the routine determination of one drug (sulfamethoxazole, sulfamethazine or sulfapyridine) in urine samples to be achieved in less than 10 min.
[Display omitted]
•Microextraction of sulfonamides in natural deep eutectic solvent (NADES).•Schiff base formation of sulfonamides in NADES based on vanillin and thymol.•Automated NADES-based microextraction for sulfonamides determination in urine.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.talanta.2021.122660</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1018-9479</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-9140 |
| ispartof | Talanta (Oxford), 2021-11, Vol.234, p.122660-122660, Article 122660 |
| issn | 0039-9140 1873-3573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2559671164 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Lab-in-syringe Liquid-liquid microextraction Natural deep eutectic solvent Sulfonamides Urea |
| title | Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A59%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Automated%20liquid-liquid%20microextraction%20and%20determination%20of%20sulfonamides%20in%20urine%20samples%20based%20on%20Schiff%20bases%20formation%20in%20natural%20deep%20eutectic%20solvent%20media&rft.jtitle=Talanta%20(Oxford)&rft.au=Shakirova,%20Firuza&rft.date=2021-11-01&rft.volume=234&rft.spage=122660&rft.epage=122660&rft.pages=122660-122660&rft.artnum=122660&rft.issn=0039-9140&rft.eissn=1873-3573&rft_id=info:doi/10.1016/j.talanta.2021.122660&rft_dat=%3Cproquest_cross%3E2559671164%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2559671164&rft_id=info:pmid/&rft_els_id=S0039914021005816&rfr_iscdi=true |