Inhibition of nuclear factor kappa B inducing kinase suppresses inflammatory responses and the symptoms of chronic periodontitis in a mouse model

Chronic periodontitis is an inflammatory disease that represents a major public health issue nowadays. Here, we investigated the protective role of nuclear factor kappa B (NF-κB) inducing kinase (NIK)-inhibitor on chronic periodontitis and revealed the underlying molecular mechanism. NIK-inhibitor w...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2021-10, Vol.139, p.106052, Article 106052
Hauptverfasser:	Wang, Jianqi, Wu, Shuainan, Li, Zhaobao, Liu, Lu, Pang, Ying, Wei, Jianming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chronic Periodontitis - drug therapy Chronic Periodontitis - genetics Chronic Periodontitis - metabolism Chronic Periodontitis - pathology Disease Models, Animal inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Lipopolysaccharides - pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - metabolism NF-kappaB-Inducing Kinase NIK-inhibitor non-canonical NF-κB pathway Osteoclasts - drug effects Osteoclasts - metabolism Osteoclasts - pathology Osteogenesis - drug effects periodontitis Protein Kinase Inhibitors - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction - drug effects
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