Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation

Antibody–drug conjugates have become one of the most actively developed classes of drugs in recent years. Their great potential comes from combining the strengths of large and small molecule therapeutics: the exquisite specificity of antibodies and the highly potent nature of cytotoxic compounds. Mo...

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Veröffentlicht in:	Bioconjugate chemistry 2021-08, Vol.32 (8), p.1834-1844
Hauptverfasser:	Orozco, Carolina T, Edgeworth, Matthew J, Devine, Paul W. A, Hines, Alistair R, Cornwell, Owen, Thompson, Christopher, Wang, Xiangyang, Phillips, Jonathan J, Ravn, Peter, Jackson, Sophie E, Bond, Nicholas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal Antibody Specificity Antineoplastic Agents - chemistry Binding Sites Conjugates Conjugation Cytotoxicity Disulfide bonds Drug Design Dynamic stability Engineering Immunoconjugates Mass spectrometry Mass spectroscopy Models, Molecular Protein Conformation Scaffolds Structural stability Sulfhydryl Compounds - chemistry
Online-Zugang:	Volltext
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