Hydrostatic pressure stabilizes HIF‑1α expression in cancer cells to protect against oxidative damage during metastasis

The tissue microenvironment is known to play a pivotal role in cancer metastasis. Interstitial fluid hydrostatic pressure generally increases along with the rapid growth of malignant tumors. The aim of the present study was to investigate the role and relevant mechanism of elevated hydrostatic press...

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Veröffentlicht in:	Oncology reports 2021-10, Vol.46 (4), Article 211
Hauptverfasser:	Zhai, Da, Xu, Yong, Abdelghany, Lina, Zhang, Xu, Liang, Jingyan, Zhang, Shuohua, Guo, Changying, Li, Tao-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomechanics Carcinoma, Lewis Lung - genetics Carcinoma, Lewis Lung - pathology Cell Line, Tumor Cell Survival Disease Models, Animal Down-Regulation Experiments Histones - metabolism Hydrostatic Pressure Laboratories Lung cancer Male Medical prognosis Metastasis Mice Mice, Inbred C57BL Morphology Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Oxidative Stress Protein expression Proteins Superoxide Dismutase - metabolism Superoxide Dismutase-1 - metabolism Tumor Microenvironment Tumors Up-Regulation
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