MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) cells that can survive over 30 days after 2 Gy/day X-ray exposures. These cells also show resistance to anticancer agents and hydrogen peroxide (H2O2). We have prev...

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Veröffentlicht in:	International journal of molecular sciences 2021-08, Vol.22 (15), p.8300
Hauptverfasser:	Tomita, Kazuo, Nagasawa, Taisuke, Kuwahara, Yoshikazu, Torii, Seiji, Igarashi, Kento, Roudkenar, Mehryar Habibi, Roushandeh, Amaneh Mohammadi, Kurimasa, Akihiro, Sato, Tomoaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer therapies Chemoresistance Chemotherapy Cyclooxygenase-2 Cytology Ferritin Ferroptosis Gene expression Glycolysis Hydrogen peroxide Intracellular Iron Lipid peroxidation Lipids Membrane potential MicroRNAs Mitochondria Mitochondrial DNA Morphology Oxidative stress Phosphorylation Radiation Radioresistance Reactive oxygen species Signal transduction Tumor cell lines
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