Is There One Key Step in the Metastatic Cascade?
The majority of cancer-related deaths are the result of metastases (i.e., dissemination and establishment of tumor cells at distant sites from the origin), which develop through a multi-step process classically termed the metastatic cascade. The respective contributions of each step to the metastati...
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| Veröffentlicht in: | Cancers 2021-07, Vol.13 (15), p.3693 |
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| container_title | Cancers |
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| creator | Dujon, Antoine M. Capp, Jean-Pascal Brown, Joel S. Pujol, Pascal Gatenby, Robert A. Ujvari, Beata Alix-Panabières, Catherine Thomas, Frédéric |
| description | The majority of cancer-related deaths are the result of metastases (i.e., dissemination and establishment of tumor cells at distant sites from the origin), which develop through a multi-step process classically termed the metastatic cascade. The respective contributions of each step to the metastatic process are well described but are also currently not completely understood. Is there, for example, a critical phase that disproportionately affects the probability of the development of metastases in individual patients? Here, we address this question using a modified Drake equation, initially formulated by the astrophysicist Frank Drake to estimate the probability of the emergence of intelligent civilizations in the Milky Way. Using simulations based on realistic parameter values obtained from the literature for breast cancer, we examine, under the linear progression hypothesis, the contribution of each component of the metastatic cascade. Simulations demonstrate that the most critical parameter governing the formation of clinical metastases is the survival duration of circulating tumor cells (CTCs). |
| doi_str_mv | 10.3390/cancers13153693 |
| format | Article |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Breast cancer Cancer Civilization Life Sciences Metastases Metastasis Probability Star & galaxy formation Tumor cells Vascular system |
| title | Is There One Key Step in the Metastatic Cascade? |
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