The role of glycosylphosphatidylinositol phospholipase C in membrane trafficking in Trypanosoma brucei

•GPI-PLC is a non-essential membrane bound enzyme in African trypanosomes.•Biosynthetic and endocytic trafficking to the lysosome are normal in GPI-PLC kncokout.•GPI-PLC knockout does affect the rate of receptor mediated endocytosis of transferrin. Glycosylphosphatidylinositol-phospholipase C (GPI-P...

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Veröffentlicht in:	Molecular and biochemical parasitology 2021-09, Vol.245, p.111409-111409, Article 111409
Hauptverfasser:	Garrison, Paige, Umaer, Khan, Bangs, James D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Glycosylphosphatidylinositol Glycosylphosphatidylinositol-specific phospholipase C Glycosylphosphatidylinositols - metabolism Lysosomes - metabolism Protein Transport Transferrin receptor Trypanosoma brucei brucei - metabolism Trypanosome Type C Phospholipases - metabolism Variant surface glycoprotein Variant Surface Glycoproteins, Trypanosoma - metabolism
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