Proanthocyanidin-functionalized hydroxyapatite nanoparticles as dentin biomodifier
•Proanthocyanidin-functionalized nano-hydroxyapatite (nHAp_PA) were synthesized.•nHAp_PA were applied on previously demineralized dentin for 1 min•Mineral content and collagen cross-links of the dentin were increased by nHAp_PA.•Mechanical properties of the dentin were improved by the nHAp_PA treatm...
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| Veröffentlicht in: | Dental materials 2021-09, Vol.37 (9), p.1437-1445 |
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| creator | Enrich-Essvein, Tattiana Rodríguez-Navarro, Alejandro B. Álvarez-Lloret, Pedro Cifuentes-Jiménez, Carolina Bolaños-Carmona, María V. González-López, Santiago |
| description | •Proanthocyanidin-functionalized nano-hydroxyapatite (nHAp_PA) were synthesized.•nHAp_PA were applied on previously demineralized dentin for 1 min•Mineral content and collagen cross-links of the dentin were increased by nHAp_PA.•Mechanical properties of the dentin were improved by the nHAp_PA treatment.•nHAp_PA promote remineralization while improving collagen stability in dentin.
This study evaluated the potential combined effects of nanohydroxyapatite and proanthocyanidin on the remineralization and collagen stabilization of demineralized dentin.
Seventy-five coronal dentin beams (6 × 1 × 1 mm3) were randomly allocated into five experimental groups (n = 15): Sound (no treatment), Control (pH-cycling), nHAp (nanohydroxyapatite), nHAp_PA (Proanthocyanidin-functionalized nanohydroxyapatite), and PA (proanthocyanidin) treatments. The sound group (negative control) were immersed in distilled water over the experimental period. The remaining groups were submitted to a pH-cycling process for 14 days. Following the de-re mineralization process, specimens corresponding to the control group (positive control) were immersed in distilled water whereas the test groups were immersed in 1 mL of respective solution treatment (nHAp, nHAp_PA, or PA) for 1 min. The dentin samples were analyzed to determine their chemical composition (ATR-FTIR and Thermogravimetric) and mineralogical (XRD) characteristics as well as their mechanical response, obtained by three-point bending test.
Higher phosphate content (v4 PO4: ATR-FTIR) and amount of mineral (XRD) was observed in the nHAp_PA group. Furthermore, a larger induction of collagen cross-links (ATR-FTIR) and %Organic Matter (TGA) would indicate the PA incorporation and the achievement of dentin matrix stability. These effects on dentin properties were related to increasing flexural strength (MPa), demonstrating that 15% w/v nHAp_PA treatment improved the mechanical properties of the samples.
nHAp_PA shows significant potential for promoting remineralization while improving collagen stability into demineralized dentin in a clinically feasible period of 1 min. |
| doi_str_mv | 10.1016/j.dental.2021.07.002 |
| format | Article |
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This study evaluated the potential combined effects of nanohydroxyapatite and proanthocyanidin on the remineralization and collagen stabilization of demineralized dentin.
Seventy-five coronal dentin beams (6 × 1 × 1 mm3) were randomly allocated into five experimental groups (n = 15): Sound (no treatment), Control (pH-cycling), nHAp (nanohydroxyapatite), nHAp_PA (Proanthocyanidin-functionalized nanohydroxyapatite), and PA (proanthocyanidin) treatments. The sound group (negative control) were immersed in distilled water over the experimental period. The remaining groups were submitted to a pH-cycling process for 14 days. Following the de-re mineralization process, specimens corresponding to the control group (positive control) were immersed in distilled water whereas the test groups were immersed in 1 mL of respective solution treatment (nHAp, nHAp_PA, or PA) for 1 min. The dentin samples were analyzed to determine their chemical composition (ATR-FTIR and Thermogravimetric) and mineralogical (XRD) characteristics as well as their mechanical response, obtained by three-point bending test.
Higher phosphate content (v4 PO4: ATR-FTIR) and amount of mineral (XRD) was observed in the nHAp_PA group. Furthermore, a larger induction of collagen cross-links (ATR-FTIR) and %Organic Matter (TGA) would indicate the PA incorporation and the achievement of dentin matrix stability. These effects on dentin properties were related to increasing flexural strength (MPa), demonstrating that 15% w/v nHAp_PA treatment improved the mechanical properties of the samples.
nHAp_PA shows significant potential for promoting remineralization while improving collagen stability into demineralized dentin in a clinically feasible period of 1 min.</description><identifier>ISSN: 0109-5641</identifier><identifier>EISSN: 1879-0097</identifier><identifier>DOI: 10.1016/j.dental.2021.07.002</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Chemical composition ; Collagen ; Cross-linking ; Cycles ; Demineralizing ; Dentin ; Dentin biomodification ; Dentistry ; Distilled water ; Flexural strength ; Hydroxyapatite ; Mechanical analysis ; Mechanical properties ; Mechanical response ; Mineralization ; Modulus of rupture in bending ; Nanomaterials ; Nanoparticles ; Organic matter ; pH effects ; Proanthocyanidin ; Proanthocyanidins ; Remineralization ; Solution heat treatment ; Stability</subject><ispartof>Dental materials, 2021-09, Vol.37 (9), p.1437-1445</ispartof><rights>2021 The Academy of Dental Materials</rights><rights>Copyright Elsevier BV Sep 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-5957f1e1679233f42876977a923578e3ea12192c0f5795e16d3fd2d537e5f5223</citedby><cites>FETCH-LOGICAL-c367t-5957f1e1679233f42876977a923578e3ea12192c0f5795e16d3fd2d537e5f5223</cites><orcidid>0000-0003-1680-8146 ; 0000-0002-6553-931X ; 0000-0001-5325-183X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dental.2021.07.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Enrich-Essvein, Tattiana</creatorcontrib><creatorcontrib>Rodríguez-Navarro, Alejandro B.</creatorcontrib><creatorcontrib>Álvarez-Lloret, Pedro</creatorcontrib><creatorcontrib>Cifuentes-Jiménez, Carolina</creatorcontrib><creatorcontrib>Bolaños-Carmona, María V.</creatorcontrib><creatorcontrib>González-López, Santiago</creatorcontrib><title>Proanthocyanidin-functionalized hydroxyapatite nanoparticles as dentin biomodifier</title><title>Dental materials</title><description>•Proanthocyanidin-functionalized nano-hydroxyapatite (nHAp_PA) were synthesized.•nHAp_PA were applied on previously demineralized dentin for 1 min•Mineral content and collagen cross-links of the dentin were increased by nHAp_PA.•Mechanical properties of the dentin were improved by the nHAp_PA treatment.•nHAp_PA promote remineralization while improving collagen stability in dentin.
This study evaluated the potential combined effects of nanohydroxyapatite and proanthocyanidin on the remineralization and collagen stabilization of demineralized dentin.
Seventy-five coronal dentin beams (6 × 1 × 1 mm3) were randomly allocated into five experimental groups (n = 15): Sound (no treatment), Control (pH-cycling), nHAp (nanohydroxyapatite), nHAp_PA (Proanthocyanidin-functionalized nanohydroxyapatite), and PA (proanthocyanidin) treatments. The sound group (negative control) were immersed in distilled water over the experimental period. The remaining groups were submitted to a pH-cycling process for 14 days. Following the de-re mineralization process, specimens corresponding to the control group (positive control) were immersed in distilled water whereas the test groups were immersed in 1 mL of respective solution treatment (nHAp, nHAp_PA, or PA) for 1 min. The dentin samples were analyzed to determine their chemical composition (ATR-FTIR and Thermogravimetric) and mineralogical (XRD) characteristics as well as their mechanical response, obtained by three-point bending test.
Higher phosphate content (v4 PO4: ATR-FTIR) and amount of mineral (XRD) was observed in the nHAp_PA group. Furthermore, a larger induction of collagen cross-links (ATR-FTIR) and %Organic Matter (TGA) would indicate the PA incorporation and the achievement of dentin matrix stability. These effects on dentin properties were related to increasing flexural strength (MPa), demonstrating that 15% w/v nHAp_PA treatment improved the mechanical properties of the samples.
nHAp_PA shows significant potential for promoting remineralization while improving collagen stability into demineralized dentin in a clinically feasible period of 1 min.</description><subject>Chemical composition</subject><subject>Collagen</subject><subject>Cross-linking</subject><subject>Cycles</subject><subject>Demineralizing</subject><subject>Dentin</subject><subject>Dentin biomodification</subject><subject>Dentistry</subject><subject>Distilled water</subject><subject>Flexural strength</subject><subject>Hydroxyapatite</subject><subject>Mechanical analysis</subject><subject>Mechanical properties</subject><subject>Mechanical response</subject><subject>Mineralization</subject><subject>Modulus of rupture in bending</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Organic matter</subject><subject>pH effects</subject><subject>Proanthocyanidin</subject><subject>Proanthocyanidins</subject><subject>Remineralization</subject><subject>Solution heat treatment</subject><subject>Stability</subject><issn>0109-5641</issn><issn>1879-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-Aw8FL15ak7Rpmosgi1-woIieQ0wmbEo3WZOsuP56W9aTB0_DwDPv8D4InRNcEUzaq74y4LMaKoopqTCvMKYHaEY6LkqMBT9EM0ywKFnbkGN0klKPMW6oIDP08hyD8nkV9E55Z5wv7dbr7IJXg_sGU6x2Joavndqo7DIUXvmwUTE7PUAqVCqmz84X7y6sg3HWQTxFR1YNCc5-5xy93d2-Lh7K5dP94-JmWeq65blkgnFLgLRc0Lq2De14KzhX48Z4BzUoQomgGlvGBRs5U1tDDas5MMsorefocp-7ieFjCynLtUsahkF5CNskKWNiKtnVI3rxB-3DNo4VJ4rTljDaTIHNntIxpBTByk10axV3kmA5iZa93IuWk2iJuRxFj2fX-zMYy36OAmTSDrwG4yLoLE1w_wf8ADu7iIM</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Enrich-Essvein, Tattiana</creator><creator>Rodríguez-Navarro, Alejandro B.</creator><creator>Álvarez-Lloret, Pedro</creator><creator>Cifuentes-Jiménez, Carolina</creator><creator>Bolaños-Carmona, María V.</creator><creator>González-López, Santiago</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1680-8146</orcidid><orcidid>https://orcid.org/0000-0002-6553-931X</orcidid><orcidid>https://orcid.org/0000-0001-5325-183X</orcidid></search><sort><creationdate>202109</creationdate><title>Proanthocyanidin-functionalized hydroxyapatite nanoparticles as dentin biomodifier</title><author>Enrich-Essvein, Tattiana ; 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This study evaluated the potential combined effects of nanohydroxyapatite and proanthocyanidin on the remineralization and collagen stabilization of demineralized dentin.
Seventy-five coronal dentin beams (6 × 1 × 1 mm3) were randomly allocated into five experimental groups (n = 15): Sound (no treatment), Control (pH-cycling), nHAp (nanohydroxyapatite), nHAp_PA (Proanthocyanidin-functionalized nanohydroxyapatite), and PA (proanthocyanidin) treatments. The sound group (negative control) were immersed in distilled water over the experimental period. The remaining groups were submitted to a pH-cycling process for 14 days. Following the de-re mineralization process, specimens corresponding to the control group (positive control) were immersed in distilled water whereas the test groups were immersed in 1 mL of respective solution treatment (nHAp, nHAp_PA, or PA) for 1 min. The dentin samples were analyzed to determine their chemical composition (ATR-FTIR and Thermogravimetric) and mineralogical (XRD) characteristics as well as their mechanical response, obtained by three-point bending test.
Higher phosphate content (v4 PO4: ATR-FTIR) and amount of mineral (XRD) was observed in the nHAp_PA group. Furthermore, a larger induction of collagen cross-links (ATR-FTIR) and %Organic Matter (TGA) would indicate the PA incorporation and the achievement of dentin matrix stability. These effects on dentin properties were related to increasing flexural strength (MPa), demonstrating that 15% w/v nHAp_PA treatment improved the mechanical properties of the samples.
nHAp_PA shows significant potential for promoting remineralization while improving collagen stability into demineralized dentin in a clinically feasible period of 1 min.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><doi>10.1016/j.dental.2021.07.002</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1680-8146</orcidid><orcidid>https://orcid.org/0000-0002-6553-931X</orcidid><orcidid>https://orcid.org/0000-0001-5325-183X</orcidid></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Chemical composition Collagen Cross-linking Cycles Demineralizing Dentin Dentin biomodification Dentistry Distilled water Flexural strength Hydroxyapatite Mechanical analysis Mechanical properties Mechanical response Mineralization Modulus of rupture in bending Nanomaterials Nanoparticles Organic matter pH effects Proanthocyanidin Proanthocyanidins Remineralization Solution heat treatment Stability |
| title | Proanthocyanidin-functionalized hydroxyapatite nanoparticles as dentin biomodifier |
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