Altona Prognostic Index: A New Prognostic Index for ER-Positive and Her2-Negative Breast Cancer of No Special Type

Simple Summary Breast cancer is the most common tumor-related cause of death in women in Europe and worldwide. The aim of our retrospective study, including 6654 women, was on the one hand to verify the validity of the worldwide known Nottingham prognostic index (NPI), and on the other hand to creat...

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Veröffentlicht in:	Cancers 2021-07, Vol.13 (15), p.3799, Article 3799
Hauptverfasser:	Wegscheider, Anne-Sophie, Ulm, Bernhard, Friedrichs, Kay, Lindner, Christoph, Niendorf, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cancer therapies Carcinoma Chemotherapy Disease ErbB-2 protein Estrogen receptors Estrogens Invasiveness Life Sciences & Biomedicine Lymphatic system Medical prognosis Oncology Patients Prediction models Questionnaires Science & Technology Survival Tumors Variables Womens health
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Zusammenfassung:	Simple Summary Breast cancer is the most common tumor-related cause of death in women in Europe and worldwide. The aim of our retrospective study, including 6654 women, was on the one hand to verify the validity of the worldwide known Nottingham prognostic index (NPI), and on the other hand to create a new model with even more prognostic validity. Our newly developed Altona prognostic index (API) shows significantly superior outcome in calculating progression free survival. In contrast to the NPI, the API considers characteristics such as subtypes of breast cancer, as this disease is heterogenous involving different entities, and patient's age. Evaluating progression free survival in different subgroups, our study shows that both these prognostic indices should only be applied on a patient collective that is
ISSN:	2072-6694 2072-6694
DOI:	10.3390/cancers13153799