Rodent models of hypertension
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular disease. As a multifactorial and systemic disease that involves multiple organs and systems, hypertension remains a challenging disease to study. Models of hypertension are invaluable to support the discovery o...
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| Veröffentlicht in: | British journal of pharmacology 2022-03, Vol.179 (5), p.918-937 |
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| container_title | British journal of pharmacology |
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| creator | Jama, Hamdi A. Muralitharan, Rikeish R. Xu, Chudan O'Donnell, Joanne A. Bertagnolli, Mariane Broughton, Bradley R. S. Head, Geoffrey A. Marques, Francine Z. |
| description | Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular disease. As a multifactorial and systemic disease that involves multiple organs and systems, hypertension remains a challenging disease to study. Models of hypertension are invaluable to support the discovery of the specific genetic, cellular and molecular mechanisms underlying essential hypertension, as well as to test new possible treatments to lower BP. Rodent models have proven to be an invaluable tool for advancing the field. In this review, we discuss the strengths and weaknesses of rodent models of hypertension through a systems approach. We highlight the ways how target organs and systems including the kidneys, vasculature, the sympathetic nervous system (SNS), immune system and the gut microbiota influence BP in each rodent model. We also discuss often overlooked hypertensive conditions such as pulmonary hypertension and hypertensive‐pregnancy disorders, providing an important resource for researchers.
LINKED ARTICLES
This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc |
| doi_str_mv | 10.1111/bph.15650 |
| format | Article |
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LINKED ARTICLES
This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/bph.15650</identifier><identifier>PMID: 34363610</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Ang II ; Animal models ; Animals ; Blood pressure ; Cardiovascular disease ; Cardiovascular Diseases ; DOCA ; Female ; Hypertension ; Immune system ; Inflammation ; Intestinal microflora ; Kidneys ; microbiome ; Microbiota ; Molecular modelling ; Pregnancy ; Risk factors ; Rodentia ; salt ; SHR ; Sympathetic Nervous System</subject><ispartof>British journal of pharmacology, 2022-03, Vol.179 (5), p.918-937</ispartof><rights>2021 The British Pharmacological Society</rights><rights>2021 The British Pharmacological Society.</rights><rights>2022 The British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-45a79d917bffd3d07308de8e858315d68fe939629c328409058957914b2a66f33</citedby><cites>FETCH-LOGICAL-c3880-45a79d917bffd3d07308de8e858315d68fe939629c328409058957914b2a66f33</cites><orcidid>0000-0002-1093-1445 ; 0000-0002-7577-2123 ; 0000-0002-7623-137X ; 0000-0002-8434-1050 ; 0000-0003-4920-9991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbph.15650$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbph.15650$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34363610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jama, Hamdi A.</creatorcontrib><creatorcontrib>Muralitharan, Rikeish R.</creatorcontrib><creatorcontrib>Xu, Chudan</creatorcontrib><creatorcontrib>O'Donnell, Joanne A.</creatorcontrib><creatorcontrib>Bertagnolli, Mariane</creatorcontrib><creatorcontrib>Broughton, Bradley R. S.</creatorcontrib><creatorcontrib>Head, Geoffrey A.</creatorcontrib><creatorcontrib>Marques, Francine Z.</creatorcontrib><title>Rodent models of hypertension</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular disease. As a multifactorial and systemic disease that involves multiple organs and systems, hypertension remains a challenging disease to study. Models of hypertension are invaluable to support the discovery of the specific genetic, cellular and molecular mechanisms underlying essential hypertension, as well as to test new possible treatments to lower BP. Rodent models have proven to be an invaluable tool for advancing the field. In this review, we discuss the strengths and weaknesses of rodent models of hypertension through a systems approach. We highlight the ways how target organs and systems including the kidneys, vasculature, the sympathetic nervous system (SNS), immune system and the gut microbiota influence BP in each rodent model. We also discuss often overlooked hypertensive conditions such as pulmonary hypertension and hypertensive‐pregnancy disorders, providing an important resource for researchers.
LINKED ARTICLES
This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc</description><subject>Ang II</subject><subject>Animal models</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases</subject><subject>DOCA</subject><subject>Female</subject><subject>Hypertension</subject><subject>Immune system</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>Kidneys</subject><subject>microbiome</subject><subject>Microbiota</subject><subject>Molecular modelling</subject><subject>Pregnancy</subject><subject>Risk factors</subject><subject>Rodentia</subject><subject>salt</subject><subject>SHR</subject><subject>Sympathetic Nervous System</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1Lw0AQQBdRbK0e_AFKwYse0u7sZr-OWvyCgiJ6XpLsLk1JsjHbIP33rqZ6EJzLHObxGB5Cp4BnEGeet6sZMM7wHhpDKnjCqIR9NMYYiwRAyhE6CmGNcTwKdohGNKWccsBjdPbijW020zquKky9m662re02tgmlb47RgcuqYE92e4Le7m5fFw_J8un-cXG9TAoqJU5SlgllFIjcOUMNFhRLY6WVTFJghktnFVWcqIISmWKFmVRMKEhzknHuKJ2gy8Hbdv69t2Gj6zIUtqqyxvo-aMKYSolQSkX04g-69n3XxO804UQA4YJDpK4Gquh8CJ11uu3KOuu2GrD-aqZjM_3dLLLnO2Of19b8kj-RIjAfgI-ystv_Tfrm-WFQfgLZS3F8</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Jama, Hamdi A.</creator><creator>Muralitharan, Rikeish R.</creator><creator>Xu, Chudan</creator><creator>O'Donnell, Joanne A.</creator><creator>Bertagnolli, Mariane</creator><creator>Broughton, Bradley R. S.</creator><creator>Head, Geoffrey A.</creator><creator>Marques, Francine Z.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1093-1445</orcidid><orcidid>https://orcid.org/0000-0002-7577-2123</orcidid><orcidid>https://orcid.org/0000-0002-7623-137X</orcidid><orcidid>https://orcid.org/0000-0002-8434-1050</orcidid><orcidid>https://orcid.org/0000-0003-4920-9991</orcidid></search><sort><creationdate>202203</creationdate><title>Rodent models of hypertension</title><author>Jama, Hamdi A. ; Muralitharan, Rikeish R. ; Xu, Chudan ; O'Donnell, Joanne A. ; Bertagnolli, Mariane ; Broughton, Bradley R. S. ; Head, Geoffrey A. ; Marques, Francine Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-45a79d917bffd3d07308de8e858315d68fe939629c328409058957914b2a66f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ang II</topic><topic>Animal models</topic><topic>Animals</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases</topic><topic>DOCA</topic><topic>Female</topic><topic>Hypertension</topic><topic>Immune system</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>Kidneys</topic><topic>microbiome</topic><topic>Microbiota</topic><topic>Molecular modelling</topic><topic>Pregnancy</topic><topic>Risk factors</topic><topic>Rodentia</topic><topic>salt</topic><topic>SHR</topic><topic>Sympathetic Nervous System</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jama, Hamdi A.</creatorcontrib><creatorcontrib>Muralitharan, Rikeish R.</creatorcontrib><creatorcontrib>Xu, Chudan</creatorcontrib><creatorcontrib>O'Donnell, Joanne A.</creatorcontrib><creatorcontrib>Bertagnolli, Mariane</creatorcontrib><creatorcontrib>Broughton, Bradley R. 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In this review, we discuss the strengths and weaknesses of rodent models of hypertension through a systems approach. We highlight the ways how target organs and systems including the kidneys, vasculature, the sympathetic nervous system (SNS), immune system and the gut microbiota influence BP in each rodent model. We also discuss often overlooked hypertensive conditions such as pulmonary hypertension and hypertensive‐pregnancy disorders, providing an important resource for researchers.
LINKED ARTICLES
This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34363610</pmid><doi>10.1111/bph.15650</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-1093-1445</orcidid><orcidid>https://orcid.org/0000-0002-7577-2123</orcidid><orcidid>https://orcid.org/0000-0002-7623-137X</orcidid><orcidid>https://orcid.org/0000-0002-8434-1050</orcidid><orcidid>https://orcid.org/0000-0003-4920-9991</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 2022-03, Vol.179 (5), p.918-937 |
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| subjects | Ang II Animal models Animals Blood pressure Cardiovascular disease Cardiovascular Diseases DOCA Female Hypertension Immune system Inflammation Intestinal microflora Kidneys microbiome Microbiota Molecular modelling Pregnancy Risk factors Rodentia salt SHR Sympathetic Nervous System |
| title | Rodent models of hypertension |
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