Zoledronic Acid Deteriorates Soft and Hard Tissue Healing of Murine Tooth Extraction Sockets in a Dose-Dependent Manner

The pathophysiology, histopathology, and immunopathology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) Stage 0 remain unclear. The aim of this study was to investigate the effects of high-dose bisphosphonates on tooth extraction socket healing by creating a murine model of BRONJ Stage 0...

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Veröffentlicht in:	Calcified tissue international 2022-01, Vol.110 (1), p.104-116
Hauptverfasser:	Kozutsumi, Ryohei, Kuroshima, Shinichiro, Kaneko, Haruka, Sasaki, Muneteru, Ishisaki, Akira, Sawase, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biochemistry Biomedical and Life Sciences Bisphosphonate-Associated Osteonecrosis of the Jaw Bisphosphonates Bone Density Conservation Agents - pharmacology Bone healing Bone marrow Cell Biology Computed tomography Connective tissue Connective tissues Diphosphonates - pharmacology Endocrinology Enzyme-linked immunosorbent assay Female Histopathology Jaw Leukocytes (mononuclear) Life Sciences Macrophages Mice Mice, Inbred C57BL Molars Original Research Orthopedics Osteoclasts Osteonecrosis Pathophysiology Tooth Extraction Tooth extractions Tooth Socket X-Ray Microtomography Zoledronic acid Zoledronic Acid - pharmacology
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