ALP-activated probe for diagnosis of liver injury by multispectral optoacoustic tomography

In this chapter, we highlight the advantages of multispectral optoacoustic tomography (MSOT) technique and the activatable photoacoustic probes in the biomedical field, and give a brief introduction to enzyme-activated probes for disease diagnosis and therapeutic outcome evaluation. We also present...

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Veröffentlicht in:	Methods in enzymology 2021, Vol.657, p.301-330
Hauptverfasser:	Wu, Yinglong, Zeng, Fang, Sun, Lihe, Chen, Junjie, Wu, Shuizhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase Chemical and Drug Induced Liver Injury - diagnostic imaging Liver Molecular Probes Photoacoustic Techniques Tomography - methods
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container_title	Methods in enzymology
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creator	Wu, Yinglong Zeng, Fang Sun, Lihe Chen, Junjie Wu, Shuizhu
description	In this chapter, we highlight the advantages of multispectral optoacoustic tomography (MSOT) technique and the activatable photoacoustic probes in the biomedical field, and give a brief introduction to enzyme-activated probes for disease diagnosis and therapeutic outcome evaluation. We also present a detailed description of the procedures for the synthesis of an activatable small molecule probe C X-OR and confirmation of its specific response to alkaline phosphatase in solution and cells. With MSOT, the liposomal C X-OR can be utilized for detection of hepatic ALP as well as for in vivo diagnosis of drug-induced liver injury in a three-dimensional manner.
doi_str_mv	10.1016/bs.mie.2021.06.019
format	Article
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subjects	Alkaline Phosphatase Chemical and Drug Induced Liver Injury - diagnostic imaging Liver Molecular Probes Photoacoustic Techniques Tomography - methods
title	ALP-activated probe for diagnosis of liver injury by multispectral optoacoustic tomography
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