In vitro and in vivo immunoregulatory activity of sulfated fucan from the sea cucumber A. leucoprocta

The in vitro and in vivo immunoregulatory activity of a water-soluble sulfated fucan AL1-1 from the sea cucumber A. leucoprocta was elucidated. In vitro experiments showed that AL1-1 up-regulated immunostimulatory activities in RAW264.7 cells and that it could successfully promote ROS production and...

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Veröffentlicht in:	International journal of biological macromolecules 2021-09, Vol.187, p.931-938
Hauptverfasser:	Feng, Guo, Laijin, Su, Chen, Shen, Teng, Wang, Dejian, Zhou, Yin, Chen, Shoudong, Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Cytokines - metabolism Female Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Immunity, Mucosal - drug effects Immunoglobulin A, Secretory - metabolism Immunomodulating Agents - isolation & purification Immunomodulating Agents - pharmacology Immunomodulation Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Macrophage Activation - drug effects Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred ICR Nitric Oxide Synthase Type II - metabolism Phagocytosis - drug effects Polysaccharides - isolation & purification Polysaccharides - pharmacology RAW 264.7 Cells Reactive Oxygen Species - metabolism Sea cucumber Sea Cucumbers - chemistry Sulfated fucan Toll-Like Receptor 4 - metabolism
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